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77 Cards in this Set
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- 3rd side (hint)
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tizanidine
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selective a-2 agonist
for management of spasticity |
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brimonidine
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selective a-2 agonist
lowers IOP in open angle glaucoma |
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clonidine
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a-2 receptor agonist
works in brain to decrease sypmathetic outflow to PNS antihypertensive |
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ergot alkaloids
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mixed partial a-agonist
from fungus on grains |
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tyramine
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indirect adrenergic agonist
in food inactivated by MAO inhibition leads to converstion to octopamine |
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phenoxyBENZamine
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a-antagonist (irreversible)
long-acting, suicide inhibitor treats pheoCHROMocytoma (danger of malignant hypertension) |
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phentolamine
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a-antagonist
nonselective |
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prazosin
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a-1 antagonist
antihypertensive |
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tamsulosin
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a-1 antagonist
flowmax |
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doxazosin
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a-1 antagonist
antihypertensive anti bph |
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terazosin
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a-1 antagonist
anti bph antihypertensive |
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methoxamine
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a-1 agonist
rapidly increases bp treats hypotensive emergency |
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phenylepherine
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a-1 agonist
sudafed pe associate with methoxamine |
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Amphetamine
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Indirect adrenergic agonist
major CNS action increases DA-positive reinforcement Adderall |
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octopamine
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converted from tyramine by MAO
accumulates in vescicles sympatholytic, decr BP |
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baclofen
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Centrally-acting skeletal muscle relaxant
GABA agonist |
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dantrolene
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skeketal muscle relaxant
within muscle cell at SR, inhibits Ca++ release treats malignant hyperthermia |
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methocarbamol
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centrally-acting skeletal relaxant
GABA agonist works at spinal reflex arch |
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methamphetamine
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indirect adrenergic agonist
strong CNS action high abuse potential |
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methylphenidate
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indirect adrenergic agonist
Ritaline |
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labetalol
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mixed B>a1 antagonist
antihypertensive |
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carvedilol
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mixed B>a1 antagonist
antihypertensive |
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dobutamine
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B-1 agonist
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propanolol
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prototype B blocker
nonselective |
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timolol
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B blocker
treats glaucoma, hypertension, migraines |
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atenolol
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cardioselective b-blocker
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esmolol
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cardioselective b-blocker
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short-acting
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albuterol
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b-2 agonist
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bronchospasm
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salmeterol
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b-2 agonist
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inhaler bronchial asthma
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levalbuterol
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b-2 agonist
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bronchospasms, COPD
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isoproterenol
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nonselective b-agonist
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manages bronchospasms
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ephedrine
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(ep)artial indirect adrenergic agonist
releases NE |
ephedra, dietary supplement
ma huang |
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pseudoephedrine
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(p)artial indirect adrenergic agonist
releases NE |
used to make meth
decongestant |
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phentermine
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(p)artial indirect adrenergic agonist
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anorexic (appetite suppressing) agent
mild psychostimulant |
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-osin
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a-1 antagoinists
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BPH
hypertension |
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carbaryl
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cholinesterase inhibitor
carbamate insecticide |
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diazepam
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Centrally acting muscle relaxant
increases GABA in CNS valium |
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octopamine
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false transmitter
formed from tyramine when MAO is inhibited sympatholytic, decr. BP |
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entacapone
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COMT inhibitor
adjunct treatment of Parkinson's |
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selegiline
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MAO inhibitor
adjunct treatment Parkinson's |
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guanethidine
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sympatholytic
depletes NE from nerve terminal no CNS activity severe hypertension |
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Levodopa
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immediate precursor to dopamine
crosses bbb to increase DA in CNS (PARKINSONS?) |
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Carbidopa
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inhibits L-aromatic amino acid decarboxylase (dopa decarboxylase)
protects levodopa from metabolism in PNS PARKINSONS? |
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Norepinephrine
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good alpha and B1
weak b2 |
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ipratropium
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muscarinic receptor antagonist
bronchospasms, COPD, rhinorrhea |
belladona
iprat(r)o benz at hy sco |
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benztropine
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muscarinic receptor antagonist
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iprat(r)o
benz at hy sco |
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atropine
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muscarinic receptor antagonist
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belladona
iprat(r)o benz at hy sco |
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hyoscyamine
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muscarinic receptor antagonist
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belladona
iprat(r)o benz at hy sco |
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scopolamine
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muscarinic receptor antagonist
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belladona
iprat(r)o benz at hy sco |
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bethanochol
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muscarinic agonist
synthetic Ach derivative no CNS |
bETHANochOL: cures glaucoma
mushrooms: muscarine Fish: piloCARPine (cures glaucoma & makes your mouth water) sing like an organ |
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pilocarpine
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muscarinic agonist
CNS glaucoma open & closed treats xerostomia (it makes your mouth water) |
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pralidoxime
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cholinesterase reactivator, high affinity for organophosphate, pulls it off only before "aging"
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verenicline
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nicotinic agonist
smoking cessation treatment |
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succinylcholine
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depolarizing blocker of nicotinic receptors
hydrolyzed by BChE, not AChe Danger: malignant hyperthermia, treat w/Dantrolene Ca++ release causes malignant hyperthermia, dantrolene inhibits Ca++ release |
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Arecholine
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Betel nut,
muscarinic & nicotinic CNS active (drug, people love it) |
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Nicotine
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Ganglionic>NMJ
high dose = blockade |
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mecamylamine
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neuronal, nicotinic ganglionic blocker
treatment of severe hypertension |
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pancuronium
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non-depolarizing nicotinic muscle receptor blocker
adjunct to anaesthesia, intubation, long acting=pan |
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atracurium
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non-polarizing NMJ blocker
short acting |
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tubocurare
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prototype non-depolarizing NMJ blocker
also releases histamine from mast cells->>hypotension |
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edrophonium
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MG test, cholinesterase inhibitor
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donepezil
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cholinesterase inhibitor,
short acting, non-competitive |
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echothiophate
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cholinesterase inhibitor,
organophosphate treats glaucoma |
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physostigmine
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carbamate cholinesterase inhibitor,
crosses BBB |
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pyridostigmine
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carbamate, ChE inhibitor
reverses non-depolarizing blockade (increases [Ach] in NMJ to let it push off the blocker) |
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neostigmine
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carbamate, ChE inhibitor
reverses non-depolarizing blockade (increases [Ach] in NMJ to let it push off the blocker) |
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baclofen
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GABA agonist
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methocarbamol
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GABA agonist
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meth-or-car bomb =muscles relaxed
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dantrolene
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Ca++ release inhibited at SR
muscle relaxant (peripheral?) |
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botox
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blocks Ach release from NMJ
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Bretylium
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Blocks NE from nerve ending
no CNS |
Raptillian- sympatholytic (no sympathy (lysis) for poor beats) anti-arrhythmic
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Cocaine
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blocks monoamine transporter, increases transmitter levels in synapse
increases DA, eupohria, abuse local anesthetic |
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Reserpine
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inhibits filling of synaptic vesicles.
yes CNS |
acts before bretylium, also sympatholytic
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Methyldopa
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a2 agonist
prodrug, converted to methyl-NE in CNS, works in CNS methyl-NE is a selective a2 agonist |
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acetylcholine
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choline acetyltransferase
choline + ACoA |
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dopamine
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renal vasodilation do tue DA receptors on kidney
doesn't cross bbb motor activity: parkinsons? positive reinforcement |
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epinephrine
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both a and b
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