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14 Cards in this Set
- Front
- Back
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drug addiction
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progressive behave syndrone
- compulsive drug seeking, comsumption - destructive - cannot alter behaviour |
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abuse problem
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- dominate
- burdensome - harm |
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drug induce pleasure state
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- important
- reward change - conserved neurobiological pathway is regulated = addictic |
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addict factors
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- short acting
- quick onset |
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reward pathway
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- reward stimulus
- reinforcing stimulus - negative stimulus canbe reinforcing |
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ventral tegmental area vta
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- from midbrain
- to nucleus accumbens - forebrain - release dopamin - form positve reiforcement |
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dopamin reward enhance
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- up release
- up effect - agonist |
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medial forebrain bundle
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- connect forebrain and midbrain
- stimulated cause strong reinforce - dopamin activate bundle - addictive drug up dopamin |
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addictive drug
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- inhibit of inhibition of dopamin release
from vta - dopamin made from tyrosin by hydroxylase |
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habituation mechanism
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- physical withdraw - reinforce
- behavior is more important - comdition is big role (environment) - positive + negative conditon from habit |
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nicotine
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- no euphobia
- powerful addictive |
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nicotine effect
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- stimulate vta
- more dopamin - nicotinic acetylcholin receptor - parasympathetic - tolerance w time |
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varenicline
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alpha4 beta2
partial agonist block nicotin activity - behavior change, suicide |
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bupropion
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antidepressant
inhibit dopamin uptake |
