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16 Cards in this Set
- Front
- Back
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What is the prototype of Osmotic Diuretics?
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Mannitol
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What is the prototype of Carbonic Anhydrase Inhibitors?
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Acetazolamide
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What is the prototype of Thiazides?
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HCTZ and Chlorthiadone
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What is the prototype of Type 1 Loop Diuretics?
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Ethacrynic Acid
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What is the prototype of Type 2 Loop Diuretics?
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Furosemide
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What is the prototype of Potassium Sparing Agonist Diuretics?
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Spironolactone and Triamterene, Amiolorade
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What are sites of Action and MOA of Osmotic Diuretics?
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Site of Action: Proximal Tubule.
MOA: Decrease Na+ reabsorption. Site of Action: Descending Loop of Henle. MOA: Increased medullary blood flow within medullary hypertonicity |
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What are sites of Action and MOA of Carbonic Anhydrase Inhibitors?
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Site of Action: Collecting Duct.
MOA: Papillary Washout. Site of Action: Proximal Tubule. MOA: Inhibits Carbonic Anhydrase and Increases Bicarbonate Excretion. |
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What are sites of Action and MOA of Thiazides?
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Site of Action: Early distal tubule & cortical TALH.
MOA: Decreases NaCl reabsorption. |
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What are sites of Action and MOA of Type 1 Loop Diuretics?
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Site of Action: Cortical & Medullary TALH.
MOA: Inhibition of Luminal Co-transport of Na+, K+, 2CL- |
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What are sites of Action and MOA of Type 2 Loop Diuretics?
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Site of Action: Cortical & Medullary TALH.
MOA: Inhibition of Luminal Co-transport of Na+, K+, 2CL- |
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What are sites of Action and MOA of Potassium Sparing Agonist Diuretics (Spironolactone) ?
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Site of Action: Cortical Collecting Tubule.
MOA: Competes for Aldosterone Receptor. |
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What are sites of Action and MOA of Potassium Sparing Agonist Diuretics (Triamterene, Amiolorade)?
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Site of Action: Cortical Collecting Tubule.
MOA: Decreases Na+ entry across luminal membrane. |
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What are examples of Osmotic Diuretics ?
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Mannitol, Sorbitol, Glucose, Sucrose
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What are the characteristics of Osmotic Diuretics?
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1) Not extensively metabolized and frequently filtered by the glomerulus
2) Limited reabsorption by Renal Tubules resulting in high concentration in the tubular lumen 3) Pharmacologically Inert 4) Direct inhibition of Water Reabsorption/ Indirect inhibition of Sodium transport of Proximal Tubules |
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What is the equation of Carbonic Anhydrase activity?
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H20 + CO2 ---(carbonic anhydrase)--> H+ and HCO3-
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