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5 Cards in this Set

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clopidogrel/ Plavix
300mg po qd for unstable angina/non-STE MI. ACS
75mg po qd for STE MI or recent MI/stroke or PAD.

Clopidogrel is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of adenosine diphosphate (ADP) receptors on platelets.
Interactions: CYP2C9, NSAIDs, omperazole,
monitoring: CBC with differential, bleeding time, hepatic function

counesling pts: notice bleeding / bruising.
Amoxicillin
Amoxil - tablet/capsule/suspension. 500mg q12h or 250mg po q8h for ear,nose, throat infxn.
3g po qd for gonorrhea acute uncomplicated infxn

amoxicillin is a semisynthetic antibiotic that inhibits the biosynthesis of cell wall mucopeptide. It has a broad-spectrum bactericidal activity against most strains of aerobic gram-positive and gram-negative microorganisms
S/E: common: NVD. serious: s-j syndrome. immunologic anaphylaxis.

Drug may decrease effectiveness of oral contraceptives with concurrent use. Recommend additional form of birth control.
antibacterial drugs, including amoxicillin, should only be used to treat bacterial infections.

Concurrent use of METHOTREXATE and AMOXICILLIN may result in methotrexate toxicity.

monitoring: CBC, hepatic and renal fxn


Atorvastatin
Lipitor. 10-20mg po qd for DM2. 10-80mg po qd for familial hypercholesterolemia.

a selective, competitive inhibitor of HMG-CoA reductase lowering plasma lipoprotein and cholesterol levels
SE: Diarrhea, abdominal pain, constipation, muscle disorders/myalgia

Advise patients to promptly report unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever.

Advise patients to contact their health care provider immediately if they become pregnant, and advise the patient of the harmful effects to the developing fetus

Concurrent use of ATORVASTATIN and GEMFIBROZIL may result in increased atorvastatin levels and an increased risk of myopathy or rhabdomyolysis.

monitoring: lipid panel, liver function, serum creatine kinase
Diltiazem
Cardizem tablet, capsule ER.120-240mg/ po qam on empty stomach for HTN.
initial, 120 to 180 mg ORALLY once daily up to 480 mg once daily for stable angina

MOA: a slow calcium channel blocker that blocks calcium ion influx during depolarization of cardiac and vascular smooth muscle. Results in dec of systolic and diastolic BP.
SE: dizziness, peripheral edema, headache

Patient should avoid activities requiring coordination until drug effects are realized, as drug may cause dizziness.
This drug may cause gingival hyperplasia, headache, or dermatologic reactions such as exfoliative dermatitis (reddened skin, skin peeling/flaking) or erythema multiforme (flu-like symptoms, spreading red rash, may progress to more severe form with blistering).

Concurrent use of ATAZANAVIR and DILTIAZEM may result in an increased risk of cardiotoxicity (prolonged PR interval).

monitoring: chest pain, ECG, BP, heart rate

dosing range for amoxil/amoxilcillin
Ear/Nose/Throat: 500mg po q 12h or 250mg po q 8h (mild/moderate); 875mg po q 12h (severe)
GU tract: 500mg po q 12h or 250mg po q 8h (mild/moderate); 875mg po q 12h (severe)
SSSI: 500mg po q 12h or 250mg po q 8h (mild/moderate); 875mg po q 12h (severe)
Lower Respiratory tract: 875mg po q 12h or 500mg po q 8h (mild/moderate/severe)
Gonorrhea: 3g as single oral dose