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27 Cards in this Set
- Front
- Back
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regions fo neuron
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- body
- dendrite - axon - presynaptic |
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cell body function
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- metabolic center (mitochondria)
- similar other - smallest of part of neuron - grey matter |
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dendrite
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- receive synaptic
- mumerous - integrate incoming infor |
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axon
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- one axon
- from hillock - send infor - branching - short to long - white matter |
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presynatic
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- end of axon
- release NT - invade dendrite+cell body |
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synapse
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- gap
- transmit b/w newron - NT diffusion |
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neuron connection
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- many (100000)
- local and long distance - overlaping - pre and post synaptic |
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E- excitability
resting neuron |
- negative inside
- driving force for (+) coming - negative protein |
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Ionic movement
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- in polar water
- not cell membrane - ion chanel |
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Neuron mambrane permeable
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- permeable to K (chanel)
- not Na, Ca, Cl (pump) |
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Maintance gradian pump
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- Na/K atpase
- Na and K chanel - Na, Ca out - K, Cl in - Ca trigger (highest action potiental) |
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Signal is
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- depolarize
- integrate at hillock |
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summation of AP
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- spatial: many places same time
- temporal: one place many time |
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AP is
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- depolarizaton
- Na chanel open - all or none - NT released - amount of NT released |
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aplitude of AP
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- frequently of fire
- during of fire -> amount of NT released |
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AP transfering
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- Na voltage chanel
- depolarization - repolarization (K chanel) - refractory (prevent back flow) |
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NT release trigger
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- Ca voltage open
- depolarization - release NT |
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NT is
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- store vescicle
- released when depola - out put infor |
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After NT released
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- transport back by pre syn or glial (drug target)
- degrade - recycle NT and vescycle |
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NT recepter
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- chemical or electrical stimulation
- inhibitory: hyperpola - excitatory: depola - integrate at hellock ->fire or not |
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Excitatory
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- depola
- open chanel - post synaptic |
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Inhibitory
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- hyperpola
- inhibit NT released - open (-) chanel or - activate Gprotein - modulate other chanel - pre or post synaptic |
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Fast transmittion
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- ligand of ion chanel
- inotropic receptor (glutamate) |
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Slow synaptic transmit
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- Gprotein
- metabotropic - excit, inhi, or modulate |
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ionotropic receptor
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- large, multiple unit - chanel
- close w/o NT - open when NT bound - close when NT detach or desensitization |
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matabotropic receptor
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- 7 transmembrane
- comformation changed when NT bound - G pro couple activated - spatialy or temporally applify signal |
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NT receptor
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- both ionic and metabolic receptor for same ligand
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