Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
14 Cards in this Set
- Front
- Back
|
What two genetic defects are known to contribute to ADHD?
|
defect in DRD4 gene
overexpression of DAT gene |
|
|
Which region of the brain is implicated in selective attention symptoms of ADHD?
|
dorsal nucleus accumbens (ACC)
|
|
|
Which region of the brain is implicated in the deficit of sustained attention for problem-solving in ADHD?
|
dorsolateral prefrontal cortex (DLPFC)
|
|
|
Which region of the brain is implicated in hyperactivity in ADHD?
|
prefrontal & supplementary motor cortices
|
|
|
Which region of the brain is implicated in impulsivity in ADHD?
|
orbital frontal cortex
|
|
|
What *physical* abnormality may be observed in the brains of ADHD patients?
|
reduced volume on the right prefrontal cortex, caudate, putamen, and globus pallidus
|
|
|
List the four generic amphetamines used to treat ADHD:
|
mixed amphetamine salts
dextroamphetamine lisdexamfetamine methamphetamine |
|
|
Which has the shorter duration of action: amphetamine or methylphenidate?
|
methylphenidate: 3-4 hours
(amphetamines: 4-5 hours) |
|
|
Amphetamine (blocks / competes for) DAT and NET, whereas methylphenidate (blocks / competes for ) DAT and NET.
|
amphetamine competes for...
methylphenidate blocks |
|
|
Which adrenergic receptor is the target in the prefrontal cortex for ADHD drugs?
|
postsynaptic alpha-2A
|
|
|
Which ADHD drug side effect is the result of stimulation of the hypothalamus?
|
appetite suppression (stimulation can cause feelings of satiety)
|
|
|
Which ADHD drug side effect is the result of stimulation of the RAS?
|
insomnia (stimulation can promote wakefulness)
|
|
|
What is the mechanism of atomoxetine? Bonus points for naming the brand.
|
atomoxetine inhibits NET
brand name: Strattera |
|
|
What is the mechanism of guanfacine? Bonus points for naming the brand targeted for ADHD.
|
guanfacine is an alpha-2A agonist.
brand name: Intuniv |
