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52 Cards in this Set
- Front
- Back
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Who is most at risk for rhabdo after recieving Sch
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children under 8 yo
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Who is at risk for developing myalgia after Sch
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men
sedentary people |
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Who is at low risk for developing myalgia after Sch
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elderly
children pregnant |
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When might Sch cause bradycardia? How do we prevent this
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upon second dose
pretreat with atropine |
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When will increased IOP onset and resolve in patient receiving Sch
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4 minutes
5-7 minutes |
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What does Sch do to intragastric pressure
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Increases P
Increases LES tone |
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What does Sch do to serum K
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increases the serum K by 0.5-1 mEq/L
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What is the safe time to give Schs after burns
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before 24 hours
after 120 days |
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Normal dibucaine test
Heterozygous Homozygous |
70-80
50-69 16-30 |
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4 things that increase plasma cholinesterase
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obesity
thyrotoxicosis anxiety psychiatric disorders |
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NMB that cause histamine release
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Mivacurium
Atracurium Sch |
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% of twitch height recovery that the patient needs to regain control of upper airway muscles
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90
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NMB that will be prolonged with renal disease
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Vec
Pan |
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NMB that will be prolonged with liver disease
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everything but atrac and cisatrac
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What AB potentiate NMB
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mycins
micins |
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What are 6 drugs that potentiate NMB
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Volatile anesthetics
Local anesthetics antibiotics anticonvulsants reglan MgSO4 |
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3 drugs that antagonize nondepolarizing NMB
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chronic seizure meds
acetylcholinesterase inhibitors succinylcholine |
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5 conditions that enhance NMB
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hypothermia
respiratory acidosis decreased K decreased Ca MgSO4 |
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NMB of choice for burn patients
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Mivacurium
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What receptors does atracurium act on
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pre and postsynaptic
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3 problems with atracurium
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histamine release
laudanosine anaphylaxis |
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NMB of choice for liver/renal disease
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cisatracurium
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NMB that is not a good drug for renal or obesity
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vecuronium
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Who is roc prolonged in
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liver failure- moderate
elderly pregnancy |
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Who is pancuronium contraindicated in
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Cardiac
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What does pancuronium do to CVS
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increases HR, BP, CO
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Reversal agent for mivacurium
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edrophonium
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Reversal agent for peds
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edrophonium
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Reversal agent used most commonly
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neostigmine
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Carbamyl esters that form a chemical bond
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neotstigmine
pyridostigmine |
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Quat ammonium that forms an electrostatic bond
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edrophonium
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How will you dose neostigmine for children
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decrease the dose
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Which Achesterase inhibitor has an active metabolite
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Neostigmine
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Onset and duration of edrophonium
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1-2 minutes
5-20 minutes |
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Onset and duration of Neostigmine
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7-11 minutes
40-60 minutes |
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Onset and duration of pyridostigmine
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16
90 minutes |
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Anticholinergic that doesn't cross the BBB and is used with Neostigmine
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gylcopyrrolate
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What anticholinergic is used when reversing with edrophonium
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atropine
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Max dose of neostigmine
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5 mg/day
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When administering Sch who is most likely to experience bradycardia
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children
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When administering a second dose of Sch who is most likely to experience bradycardia
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adults
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What is the dibucaine test for
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plasma cholinesterase abnormality
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What pharmacokinetic adjustments and expectations will you have with liver failure with non-depolarizing NMB
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larger loading dose
decreased clearance |
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What does reglan do to plasma cholinesterase
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inhibits it
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Metabolizes mivacurium
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plasma cholinesterase
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Metabolizes atracurium
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plasma esterases
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What is the atracurium dose after sch
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0.25
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Good CV drug that is slightly vagotonic
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vecuronium
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Respiratory condition that could prolong vec
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hypercarbia
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What is rocuronium's metabolism
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minimal
excreted unchanged by kidneys and in BILE |
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NMB with a vagal blockade
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Pancuronium
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NMB that may cause dysrhythmias when given with digoxin
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Pacuronium
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