Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
6 Cards in this Set
- Front
- Back
|
Interactions with clinical therapy -How do we define an interaction? |
A change in a drug’s function/effect when administered with food or another drug or substance. |
|
|
How do we define an interaction? |
Food (Milk) Herbals (St. John’s Wort) Drugs Lifestyle (Smoking, Alcohol) |
|
|
When will an interaction become significantly important? |
1.) In NTI drugs (high risk drugs) 2.) High risk patients (pregnancy, Geriatrics, Paediatrics) |
|
|
What type of interactions can we see? (Good interactions) |
-Potentiating effect (e.g. Combine Anti-biotics) -Antagonism (E.g antidote) |
|
|
What are the undesirable interactions? |
1.)Toxicity ( diuretics&NSAIDS exacerbating renal impairment) 2.) Loss of effect (Carbamazepine causes Warfarin to loose its Clinical function.) |
|
|
How can interactions affect ADME? |
1.) Absorption- Stomach/small-intestines. 2.) Distribution- tissue level 3.) Metabolism- Liver 4.) Elimination- Kidneys
NB- Interactions can occur at any stage in ADME although this depends on the route of administration e.g. oral route has more of a risk of interactions than an IV bolus |
