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54 Cards in this Set
- Front
- Back
Polyoxins
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inhibit chitin synthetase
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inhibit chitin synthesis
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benzoylphenylureas
diflubenzuron or dimilin |
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precocenes
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destory JH synthesis cells of corpora allata
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Ecdysone elaborated by
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prothoracic gland
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Juvenile hormone secreted by
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corpora allata
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Auxins
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promote growth longitudinal axis
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Gibberellic acid
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rapid elongation
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Ethylene
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acceleraton of againg process
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cytokinins
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cell division and protein synthesis
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Abscisic acid
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dormancy in seeds
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pyruvate dehydrogenase is inhibited by
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As-, Cu- combining with -SH
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lethal synthesis example would be _____ and what does it do?
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fluoroacetate turning into fluorocitric acid
inhibits aconitase and interferes with citrate transport at mitochondrial membrane |
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Rotenone and piercidin A
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blocks NADH oxidase in ETC
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Oxathiine fungicide
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block succinic dehydrogenase in ETC
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Cyanide
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blocks cytochrome oxidase in Oxidative phosphorylation.
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Example of uncouplers and how they work
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In oxidative phosphorylation- dinitrophenol derivatives
donate proton across the lipid contaning mitochondrial membrane thus destroys the proton differential and leads to cleaving ATP to ADP. |
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Triorganotin
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inhibitors of oxidative phosphorylation- prevent ATP formation
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trifluralin herbicide
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interfere with microtubule formation
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benomyl fungicide
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interfere with microtubule formation
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Streptomycin
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binds with one molecule per ribosome subunit to cause misreading of genetic code
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Sulfonylurea herbicides
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inhibit acetohydroxyacid synthase resulting in indirect block of DNA synthesis
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Chloroacetanilide herbicide
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react with nucleophiles to block protein synthesis.
also affect gibberellin biosynthesis |
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Endothall
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inhibits PP2A
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indoleacetic acid
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2,4-D
persistent auxin that exaggerate normal auxin action. |
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Ethephon
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directly releases ethylene
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Tetram- what is the importance of this compound?
what does it do? |
OP, systemic for control of bark beetle that transmit dutch elm disease. not degraded fast enough and caused ACHE depression in mammals.
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reactions with carbohydrates in mammals yields
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glucuronides
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reactions with carbohydrates in plants and insects yields
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glucosides
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cyanide converts to ___________ and by what?
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thiocyanate and rhodanese
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atrazine- why is it safe to corn but not weed?
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corn removes Cl and attach GSH residue
slow in weeds. |
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piperonyl butoxide
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block oxidases
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organophosphorus esters
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block hydrolases
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dichloroacetamide herbicide safener
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induces the synthesis of GSH and GSH s-transferase.
enhance the detoxification of some herbicidies. |
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Due to single amino acid change of from what to what? cause Triazine resistance at ________ site.
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alanine to serine.
Triazine resistance at PSII site. |
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Voltage dependent sodium channel
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DDT and pyrethroids
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what is Nerve insensitive factors?
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mutant with single amino acid change confers knockdown resistance. or more than one change give super kdr.
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Know the examples of toxicity classes that are highly or moderately toxic
Insecticides |
OPs, methylcarbamates
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Know the examples of toxicity classes that are highly or moderately toxic
Herbicides |
paraquat, endothal, dinitrophenols
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Know the examples of toxicity classes that are highly or moderately toxic
Fungicides |
organotins
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Antidotes for organophosphates
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atropine sulfate, propam chloride intravenously.
Do not use morphine, theophyllin, aminophyllin or barbiturates |
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Antidotes for carbamates
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atropine sulfate.
do not use propam chloride |
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Antidotes for chlorinated hydrocarbons
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barbiturates
do not use epinephrine |
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Antidotes for Arsenicals
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BAL (dimercaprol)
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Anticoagulant rodenticides
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vitamin K. with vitamin C
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No antidotes for
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chlorophenoxy, urea herbicides, endothall, diquat, paraquat.
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Malathion and some pyrethroids selectivity is attributable by what and how?
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esterases
hydrolyzing carbethoxy or cyclopropanecarboxylate ester groups more rapidly in mamals than in insects. |
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Propanail herbicide selectivity attributable to rapid hydrolysis by ________ but this is inhibited by _____ or ____
insecticides |
amidase
OP, MC |
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dichlormid
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herbicide antidote
increases selectivity of EPTC herbicide by increasing detoxification of active sulfoxide intermediate via GSH system. |
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what is the importance of para-aminobenzoic acid
what compound inhibits this and what does it inhibit? |
essential for majority of pathogenic bacteria (synthesizes to folic acid)
sulphanilamide. inhibits dihydropteroate synthase |
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warfarin
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rodenticide, anticoagulant
vitamin K antagonist |
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Thalidomide
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Teratogens
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one compound _________ may sensitize the photodecomposition of another __________ to give new toxicant ____________
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Rotenone dieldrin photodieldrin
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Malathion toxicity increased by
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EPN
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Propanil herbicide toxicity increased or decreased by __________ and due to ___________
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OC and MC insecticides
CYP 450 inhibition. |