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30 Cards in this Set
- Front
- Back
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Fasciculations are findings of impairment to...
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motor neuron integrity
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Autonomic Neuropathy gives rise to
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orthostatic htn
trophic skin changes arrhythmias pupillary changes GI motility dysfunction impotency |
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What are the pathological processses of peripheral neuropathy?
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Wallerian Degeneration
Axonal Degeneration Neuronopathy Segmental Demyelination |
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What is Wallerian Degeneration?
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Transected nerve due to trauma. The distal end dies off.
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What is the most common cause of PN in the US?
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Diabetic PN
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What is the accepted pathophys of Diabetic PN?
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Hyperglycemia-->accumulation of sorbitol-->free radicals-->nerve damage
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What is the most common subtype of DN?
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Polyneuropathy
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What are the characteristics of Diabetic Polyneuropathy?
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Stocking/Glove pattern
Predominantly sensory Axonal Neuropathy |
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In D. PolyN, which is affected first:
1) sensory/motor 2) short nerves/long nerves |
1) sensory
2) long nerves |
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What is Diabetic Amyotrohpy?
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Damage to a bundle of nerves with u/k cause. Usu. lumbar plexus.
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Fasciculations are findings of impairment to...
|
motor neuron integrity
|
|
|
Autonomic Neuropathy gives rise to
|
orthostatic htn
trophic skin changes arrhythmias pupillary changes GI motility dysfunction impotency |
|
|
What are the pathological processses of peripheral neuropathy?
|
Wallerian Degeneration
Axonal Degeneration Neuronopathy Segmental Demyelination |
|
|
What is Wallerian Degeneration?
|
Transected nerve due to trauma. The distal end dies off.
|
|
|
What is the most common cause of PN in the US?
|
Diabetic PN
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|
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What is the accepted pathophys of Diabetic PN?
|
Hyperglycemia-->accumulation of sorbitol-->free radicals-->nerve damage
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|
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What is the most common subtype of DN?
|
Polyneuropathy
|
|
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What are the characteristics of Diabetic Polyneuropathy?
|
Stocking/Glove pattern
Predominantly sensory Axonal Neuropathy |
|
|
In D. PolyN, which is affected first:
1) sensory/motor 2) short nerves/long nerves |
1) sensory
2) long nerves |
|
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What is Diabetic Amyotrohpy?
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Damage to a bundle of nerves with u/k cause. Usu. lumbar plexus.
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How does diabetic amyotrophy present?
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severe pain in hip, low back, and ant. thigh
high protein in CSF (due to protein release from N damage) |
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What are other systemic causes of PN?
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Renal Failure
Hepatic d/o Thyroid d/o vascular/rheumatologic Critical illness neoplasm (compression) porphyria (abnl heme synthesis) |
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What is Guillain Barre Syndrome?
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Immune attack on the nerves and nerve roots
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What is the most common acquired demyelinating polyneuropathy?
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GBS
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The myelin protein that is attacked by Abs in GBS is
1) ? 2) similar to the moiety on what bac? |
1)GMI
2) Campylobacter |
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What part of the NMJ do the GMI Abs attack?
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The pre-synaptic end plate
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What is the presentation of GBS?
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Facial weakness
Autonomic N abnormalities: dysrhythmias, hemodynamic abnlities Areflexia High CSF protein |
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What is the main hereditary motor and sensory neuropathy?
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Charcot-Marie-Tooth
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Type 1 CMT affects axon or myelin?
Type 2 CMT affects axon or myelin? |
Type 1: myelin
Type 2: axon |
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What are the clinical features of CMT?
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Distal weakness
Atrophy MSK deformities Hammer toes |
