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11 Cards in this Set
- Front
- Back
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What is the most common form of NHL? |
DLBCL- diffuse large B cell lymphoma. |
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What is the role of BCL6? |
Repress the expression of factors that normally serve to promote germinal center B cell differentiation, growth arrest and apoptosis. BCL6 is required for the formation of normal germinal centers. |
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What is the main pathogenesis of DLBCL? |
Dysregulation of BCL6. |
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10 to20% of DLBCL are associated with what translocation ? (Not bcl6) |
14;18 -BCL2. |
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Can there be BCL2 rearrangements with BCL6 rearrangements in one DLBCL? |
No. Tumors with BCL2 rearrangements usually lack BCL6. |
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What % of DLBCL are associated with MYC translocations? |
5 |
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What is the immunophenotype of DLBCL? |
Cd19,20 Germinal cell markers: cd10 and BCL6. |
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what are special subtypes of DLBCL? 2 |
1. Immunodeficiency- associated large B cell lymphoma 2. Primary effusion lymphoma. |
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What is the characteristic feature of Immunodeficiency associated B cell lymphoma? |
Occurs in the settings of T cell immunodeficiency The neoplastic cells are usually infected with EBV. |
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What is the characteristic feature of Primary effusion lymphoma? |
The tumor cells are anaplastic in appearance Fail to express surface B or T markers. Infected with KSHV\HHV-8. |
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What are the clinical features of DLBCL? |
Rapidly enlarging mass at a nodal or extranodal site. It can arise anywhere in the body. |
