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8 Cards in this Set

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Toxoplasmosis
When: 1st-3rd TM (most severe in 1st)
Sx: Cerebral Ca++
Hydrocephalus and/or Microcephaly
Chorioretinitis
myocarditis
hepatosplenomegaly
jaundice
vomiting
IUGR
maculopapular rash
Labs:
thrombocytopenia
IgM - ELISA
IgG for life
isolate organism, culture
Tx: pyrimethamine & sulfadiazine, leucovorin
Later life:
70-90% aymp at birth
effects may not manifest until 2nd-3rd decade
up to 80% have learning and visual problems later
Rubella
When: 1st TM
Sx: Cerebral Ca++
Hydrocephalus and/or Microcephaly
Deafness
Microphthalmia
Cataracts
PDA
IUGR
cyanotic w/petechial rash (blueberry muffin)
Labs:
thrombocytopenia
IgM
HI titer
viral culture
CMV
When: ALL
Sx: Cerebral Ca++
Microcephaly
Convulsions
Meningoencephalitis
Deafness (often progressive)
Chorioretinitis
Hepatosplenomegaly
jaundice
IUGR
Labs:
PCR for CMV DNA
viral culture

90% asymp)
HSV
When: ALL, into PP
Sx: Hydranencephaly
Microcephaly
Chorioretinitis
Microphthalmia
cerebral Ca++
encephalitis
pneumonia
hepatosplenomegaly
Cutaneous vesicles
" scars
Labs:
PCR for HSV DNA
viral culture
MAY APPEAR SEPTIC
Varicella
When: 1st TM & intrapartum
Sx: Microcephaly
Chorioretinitis
cataracts
convulsions
Microphthalmia
myocarditis
Horner's
Cerebral Ca++
pneumonitis
visceral lesions
Cutaneous vesicles
" scars
unilat limb hypoplasia
Labs:
VZV Ab
viral culture
Syphilis - Early (<2 y/o)
MAJOR
MC Sx = periostitis
Other Sx' snuffles, rash, condyloma lata, osteochondritis/myelitis, pneumonia alba (obliterative lung fibrosis)
MINOR
perioral fissures, mucous patches, hepatosplenomegaly, lymphadenopathy, hematolgic signs, hydrops, pseudoparalysis of Parrot, SNC problems
MC Sx Syphilis <2 y/o
periostitis
Syphilis -Late (>2 y/o)
Hutchinson's TrIaD: teeth (peg-shaped upper central incisors), interstitial keratitis, deafness

frontal bossing, short maxillae, protruding mandible, saddle nose,
Clutton's joints (bilat knee effusion), saber shins, sternoclavicular thickening, flaring scapulas