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14 Cards in this Set
- Front
- Back
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peptide hormones activate what type of receptor?
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G protein membrane bound receptor
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the __ protein is activated once the protein attaches to the cell receptor.
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G
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what does the G protein activate?
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adenyl cyclase
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what does adenyl cyclase do?
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converts ATP to cAMP (cyclic AMP)
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what does cAMP do in the cell?
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acts as a secondary messenger to turn on cell function
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what is the SECONDARY MESSEGER< AGAIN?
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cAMP
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what does cAMP do next?
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activates a specific cytosolic protein kinase
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this actic=vated protein kinase will affect what?
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gene expression!
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what is the role of ADH on cAMP?
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ADH binds to the membrane bound receptor, activating g protein, which activates adenyl cyclase, which concerts ATP to cAMP. cAMP is the secondary messenger which causes the cell to insert aquaporins into the collecting duct apical membrane (water is permeable and uptake occurs)
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what happens in the absence of ADH?
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cAMP is not activated and the aquaporins are stored in cytosolic vesicles (no water uptake, no water permeability)
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what breaks down cAMP ?
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phosphodiesterases
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what does phosphodiesterase break cAMP into?
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5' AMP
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what is one inhibitor of a phosphodiesterase?
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caffine
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thus caffine, an inhibitor of phosphodiesterases( break down cAMP), must also inhibit ________insertion, leading to excess urine formation
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aquaporin
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