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15 Cards in this Set

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Where in the cell is the pentose phosphate pathway located?
cytosol
Which cells is the pentose phosphate pathway active in?
liver, mammary glands adn adipose tissue b/c NADPH is required for FA synth in these cells
reduced gluathione does what?
antioxidant that recuces protien disulfides non-enzymatically adn to enzymatically reduce hydrogen peroxide & organic peroxides via glutathione peroxidase
Glutathione Reductase
reduces GSSG -> GSH using NADPH
Oxidative branch of pathway does...
G6P oxidized to ribulose-5-phosphate
+ 2 NADPH
+ 1 CO2
Glucose 6 Phosphate dehydrogenase
G6P ox phosphoglucolactone
get NADPH
committed step but not allosterically regulated
regulated by substrate avalibility
6-phosphoglucolactone hydrolase
hydrolyzes ring opening to 6-phosphogluconate
6-phosphogluconate dehydrogenase
oxidative decarboxylation of 6-phosphogluconate to get NADPH
CO2
ribulose 5 phosphate
ribulose 5 phosphate is in equilbrium with what other 2 5C sugars?
xylose-5-phosphate
ribose-5-phosphate (aldose)
phosphopentose isomerase
ribulose-5-phos (ketone) ->
ribose-5-phose (aldose)
phosphopentose epimerase
interconverts xylose-5-phos and ribulose-5-phosphate
Transketolase
transfers 2 Carbon frag from Ketose donor to aldose acceptor
Thiamine pyrophosphate (TPP) cofactor
Transaldolase
transfers 3 carbon frags from ketose donor to aldose acceptor
schiff base intermed (AS lys)
Glucose phosphate dehydrogenase deficiency
most common
X linked
pt mutation
-> hemolytic anemia
oxidatvie stress is precipitated by
antiboitics
antimalarials
antipyretics
flava beans
infection