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15 Cards in this Set
- Front
- Back
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Where in the cell is the pentose phosphate pathway located?
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cytosol
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Which cells is the pentose phosphate pathway active in?
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liver, mammary glands adn adipose tissue b/c NADPH is required for FA synth in these cells
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reduced gluathione does what?
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antioxidant that recuces protien disulfides non-enzymatically adn to enzymatically reduce hydrogen peroxide & organic peroxides via glutathione peroxidase
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Glutathione Reductase
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reduces GSSG -> GSH using NADPH
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Oxidative branch of pathway does...
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G6P oxidized to ribulose-5-phosphate
+ 2 NADPH + 1 CO2 |
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Glucose 6 Phosphate dehydrogenase
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G6P ox phosphoglucolactone
get NADPH committed step but not allosterically regulated regulated by substrate avalibility |
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6-phosphoglucolactone hydrolase
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hydrolyzes ring opening to 6-phosphogluconate
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6-phosphogluconate dehydrogenase
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oxidative decarboxylation of 6-phosphogluconate to get NADPH
CO2 ribulose 5 phosphate |
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ribulose 5 phosphate is in equilbrium with what other 2 5C sugars?
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xylose-5-phosphate
ribose-5-phosphate (aldose) |
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phosphopentose isomerase
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ribulose-5-phos (ketone) ->
ribose-5-phose (aldose) |
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phosphopentose epimerase
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interconverts xylose-5-phos and ribulose-5-phosphate
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Transketolase
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transfers 2 Carbon frag from Ketose donor to aldose acceptor
Thiamine pyrophosphate (TPP) cofactor |
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Transaldolase
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transfers 3 carbon frags from ketose donor to aldose acceptor
schiff base intermed (AS lys) |
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Glucose phosphate dehydrogenase deficiency
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most common
X linked pt mutation -> hemolytic anemia |
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oxidatvie stress is precipitated by
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antiboitics
antimalarials antipyretics flava beans infection |
