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22 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Penicillins MOA
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bactericidal; interfere with cell wall synthesis via 1) PBPs, 2) inhibiting transpeptidases, and 3) stimulating autolysins
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narrow specturm or first generation penicillins
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Penicillin G and V
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beta-lactamase resistant penicillins or second generation
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Methicillin
Dicloxacillin Oxacillin and cloxacillin nafcillin Flucloxacillin |
especially useful for penicillin resistant staph and strp
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Nafcillin
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the only penicillin eliminated through the biliary route and not renally like all the others
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broad specturm or third generation
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Ampicillin, amoxicillin
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target gram negative and positives
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ampicillin - DOC for what?
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Listeria monocytogenes
sepsis and meningitis |
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extended specturm or "antipseudomonal pneicillins"
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well-suited to addressing Pseudomonas aeruginosa
Carbenicillin, piperacillin, ticarcillin |
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T or F: Penicillins cross the placenta but are NOT teratogenic?
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TRUE
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T or F: All penicillins are renally excreted
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FALSE:
nafcillin is excreted through the biliary route |
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1st generation cephalosporins special sensitivities
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Proteus
E. coli Klebsiella PLUS gram positives! |
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2nd generation cephalosporins special sensitivities
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Haemophilus influenzae
Enterobacter aerogenes Neisseria Proteus E. coli Klebsiella |
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3rd generation cephalosporins special sensitivities
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Haemophilus influenzae
Enterobacter aerogenes Neisseria Proteus E. coli Klebsiella PLUS enterics (intestinal bacteria) |
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1st generation cephalosporins effective against which gram staining characteristics?
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some gram negatives
MANY gram positives |
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3rd generation cephalosporins effective against which gram staining characteristics?
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MANY gram negatives
many gram positives |
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2nd gneration cephalosporins effective against which gram staining characterisitics?
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more gram negatives
many gram positives |
cefazolin
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4th generations cephalosporins effective against which organism
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pseudomonas aeruginosa
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name some second generation cephalosporins
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cefamandole
cefoxitin cefuroxime cefotetan |
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name the 3rd generationcephalosporins
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ceftazidime
cefotaxime deftriaxone |
Tough Assassins
Others are: cefoperazone and ceftrizoxime |
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Ceftriaxone - elimination and DOC
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Excreted with the bile
DOC: N. gonorrhea |
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Ceftazidime - active against
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Pseudomonas aeruginosa
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4th generation cephalosporins - names and effective against what
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Effective against Pseudomonas aeruginosa
("Pseudomonas Insults") cefePIme cefPIrome |
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What is the disulfiram reaction?
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a reaction whereby ALDEHYDE DEHYDROGENASE is inhibited, resulting in a build-up of acetaldehyde
(when alcohol is ingested during use of certain medications) |
cefamandole, cefotetan, cefoperazone, griseofulvin, sulfisoxazole, suflamethaxozole, nitrofurantoin, isoniazid, chloramphenicol, metronidazole, disulfiram, nitroglycerin, isosorbide dinitrate, tolbutamide, chlorpropamide, glyburide, tolazamide, quinacrine, toxic mushrooms
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