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27 Cards in this Set

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What are penicillins know as?
Beta-lactam antibiotics
How do all beta-lactam antibotics work?
Disruption of the cell wall
Penicillins are generally bacteri(static/cidal).
cidal
Penicillins are only effective against actively growing bacteria.
T or F
True
How do penicillins work?
Inhibition of Transpeptidase
Activation of autolysins
What do transpeptidases do?
Catalyze crossbridges of the cell wall to make it strong
What are the receptors that penicillin binds to?
penicillin binding proteins (PBP)
What bacteria are penicillins effective against?
Gram + and only some Gram -
What are beta-lactamases?
Cleave the beta-lactam ring and render antibiotic inactive
What is the prototype for the penicillin family?
Penicillin G
Penicillin G is a (broad/narrow) range agent.
Narrow
How is Penicillin G given?
IM
IV- only potassium salt
How is penicillin eliminated?
Kidneys
What are the adverse effects of Penicillin G?
Sensory or motor dysfunction (injection into nerve)
Severe reactions (Intra-arterial injection)
Allergies
What causes the penicillin allergy?
Compounds formed from the degradation of penicillin
What is a drug interaction of Penicillin?
Aminoglycosides (Penicillin inactivates it)
What Penicillin is given orally?
Penicillin V
What are the three penicillinase resistant penicillins?
Nafcillin (IV)
Oxacillin
Dicolxacillin
What is the prototypic broad spectrum drug?
Ampicillin
What does is mean when something is methicillin resistant?
Lack of susceptibility to methicillin (a penicillinase-resistant penicillin) and other same types of drugs
What are the most common side effects of ampicillin?
Rash
Diarrhea
Which is preferred for oral therapy? Ampicillin or Amoxicillin?
Amoxicillin
What is Augmentin?
Amoxicillin with Clavulanic acid
What are the Beta-lactamae Inhibitors?
Clavulanic acid
Tazobactum
Sulbactam
What is the broadest range penicillin?
Ticarcillin
Are the broad spectrum penicillins inactivated by beta-lactamaes?
Yes
What are the adverse effects of Ticarcillin?
Sodium Overload
Promote Bleeding