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10 Cards in this Set

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Narrow Spectrem Penicillins consist of _1__ & __2__

Extended Spectrum consist of
__3___, __4___,__5___ &__6___


Penicillinase Resistant Drugs consists of __7___, ___8___,___9___, ___10___.
1. Pen G-can't breakdown in
gut
2. Pen V
3.Amoxicillin
4. Ampicillin
5.Piperacillin
6.ticarcillin
7.Dicioxacillin
8.Cloxacillin
9.Nafcillin
10. Methacillin
Penicillin:Pharmokinectics
Acid stable dose __1__

Acid Labile dose __2___

Distributed to most tissue except__3__. (except in the case of meningitis)

Primarily excreted via __4___
1. orally
2. injections
3. CNS
4. Kidneys
(ampicillina and nafcillin
excreted via bile)
Penicillins:Indications & Use
Narrow Spectrum:Pen _1_ & _2_

Treat: streptococci, __3___ &
__4____

Not used much due to: 5.
1. G
2. V
3. meingococci
4. spirochetes
5. Resistance
Penicillins:Indications & Use
Extended Spectrum: 2 groups
Group 1
Aminopenicllins
Group 2
Anti Psuedomonas
1.Amoxicillin & Ampicillin

2. Piperacillin & Ticar
(hard to kill, lots of
resistance)
Amoxil & Ampicillin are used against:

Augmentin preferred for resistant strains & for bite wound
-Streptococci
-Entercocci (most strains)
-Some gram negatives
-Often can be combined with
beta lactamase inhibitor
-URI
*Otitis Media
*Sinusitis
*Bronchitis
*CAP-community acquired
pneumoniae
Amoxil & Augmentin Dosing

Traditional
High Dose

Have wide safety range
Few SE are:
___1__ of GI
___2___ on skin
___3___ propensity of allergic rxn
Rare: psuedomembrane colitis aka __4___
Steven Johnson syndrom
anemia
T= 40mg/kg/day BID to TID
H= 90mg/kg/day BID to TID

1. loose stools
2. rash
3. high
4. c-diff
Ampicillin & Aminoglycosides are often use in combination therapy in:
severe infections
Drug Resistance to Penicillin
Causes:
__1___ dosing antibiotics; __2____ gene transferred from one bacteria to another bacteria or class of bacteria
1. under; bacteria fight
back if the dosage is not
strong enough
2. resistance gene; 3 to 4
days where the bacteria
are under MIC-pencillins
have longer 1/2 life
Allergic Rxn's to Penicillin

*Penicillins have the __1__
incidence of allergic rxns
*IgE mediated can cause
__2__ to __3__
*Non IgE _____4____ rxns
-serum sickness,hepatits,
interstial nephritis
-rash (mono)
1. highest
2. rash
3. anaphylaxis
4. hypersensitivity
Beta Lactamase Inhibitors are defined as:
i.e. Clavulante
Sulbactam
Tazobactam
*have no antibacterial effect independently
Beta-lactamase inhibitors are proteins designed to inhibit or destroy the effectiveness of beta-lactamase enzymes