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10 Cards in this Set
- Front
- Back
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Narrow Spectrem Penicillins consist of _1__ & __2__
Extended Spectrum consist of __3___, __4___,__5___ &__6___ Penicillinase Resistant Drugs consists of __7___, ___8___,___9___, ___10___. |
1. Pen G-can't breakdown in
gut 2. Pen V 3.Amoxicillin 4. Ampicillin 5.Piperacillin 6.ticarcillin 7.Dicioxacillin 8.Cloxacillin 9.Nafcillin 10. Methacillin |
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Penicillin:Pharmokinectics
Acid stable dose __1__ Acid Labile dose __2___ Distributed to most tissue except__3__. (except in the case of meningitis) Primarily excreted via __4___ |
1. orally
2. injections 3. CNS 4. Kidneys (ampicillina and nafcillin excreted via bile) |
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Penicillins:Indications & Use
Narrow Spectrum:Pen _1_ & _2_ Treat: streptococci, __3___ & __4____ Not used much due to: 5. |
1. G
2. V 3. meingococci 4. spirochetes 5. Resistance |
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Penicillins:Indications & Use
Extended Spectrum: 2 groups Group 1 Aminopenicllins Group 2 Anti Psuedomonas |
1.Amoxicillin & Ampicillin
2. Piperacillin & Ticar (hard to kill, lots of resistance) |
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Amoxil & Ampicillin are used against:
Augmentin preferred for resistant strains & for bite wound |
-Streptococci
-Entercocci (most strains) -Some gram negatives -Often can be combined with beta lactamase inhibitor -URI *Otitis Media *Sinusitis *Bronchitis *CAP-community acquired pneumoniae |
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Amoxil & Augmentin Dosing
Traditional High Dose Have wide safety range Few SE are: ___1__ of GI ___2___ on skin ___3___ propensity of allergic rxn Rare: psuedomembrane colitis aka __4___ Steven Johnson syndrom anemia |
T= 40mg/kg/day BID to TID
H= 90mg/kg/day BID to TID 1. loose stools 2. rash 3. high 4. c-diff |
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Ampicillin & Aminoglycosides are often use in combination therapy in:
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severe infections
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Drug Resistance to Penicillin
Causes: __1___ dosing antibiotics; __2____ gene transferred from one bacteria to another bacteria or class of bacteria |
1. under; bacteria fight
back if the dosage is not strong enough 2. resistance gene; 3 to 4 days where the bacteria are under MIC-pencillins have longer 1/2 life |
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Allergic Rxn's to Penicillin
*Penicillins have the __1__ incidence of allergic rxns *IgE mediated can cause __2__ to __3__ *Non IgE _____4____ rxns -serum sickness,hepatits, interstial nephritis -rash (mono) |
1. highest
2. rash 3. anaphylaxis 4. hypersensitivity |
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Beta Lactamase Inhibitors are defined as:
i.e. Clavulante Sulbactam Tazobactam *have no antibacterial effect independently |
Beta-lactamase inhibitors are proteins designed to inhibit or destroy the effectiveness of beta-lactamase enzymes
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