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28 Cards in this Set
- Front
- Back
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gh pulse
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1 hour after sleep
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somatostatin _____ release of GH
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inhibits
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GHRH and ghrelin ____ release of GH
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increases
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decreased gh secretion causes
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obesity, hyper/hypo thyroid, hyper/hyp glycemia,
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increased gh secretion causes
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stress, starvvation,
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diagnose GH def
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igf-bp3, igf-1
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confirm diagnosis of impaired GH secretion iwht ____ different and postitve GH stimulation tests
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2 (1 if genetic, CNS, irradiation, pitutiary hormone problem)
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clonidine tests ___ GHRH secretions, ___ stomatistatin. test should cause GH to ____.
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increase, inhibit, increase
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levodopa _____ release of GHRH, test shoud cause GH to ____
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increase, increase
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screenign tests
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clonidine and levodopa
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definitive tests
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arginine, inuslin toleracne test, glucagon
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stimulation tests
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GHRH 1-2 mg/kg IV for 1 min, peak 15-30 min
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normal GH level
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>10 ng/ml
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GH deficiency dose of GH
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0.16-0.3 mg/kg/wk
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synthetic gh is called
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somatropin
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rGH major AEs
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benign ICP: headache, vision changes, n/v
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TSH and t3 do/dont cross placenta
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dont
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trh and free t4 do/dont cross placenta
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do
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fetus can synth iodothyronines by ___weeks GA
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12
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treat congenital hyper thyroid
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levothyroxine 10-15 mcg/kg/day
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antithyroid drugs
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methimazole
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dose range of methimazole
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0.25-1 mg/kg/day
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methimazole side effects
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agranulocytosis, lupus-like, hepatitis, liver failure
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hypothyroid s/s
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weight gain, cold intolerance, coarse hair, bradycardia, fatigue, dry skin, periorbital swelling, declining growth velocity
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hyperthyroid s/s
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wt loss, heat intolerance, goiter, fine hiar, tachycardia, lid lag, accelerated growth, anxiety, sweating
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levothyroxine dose 1-5yr
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5-6 mcg/kg/day
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levothyroxine dose 6-12yr
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4-5 mcg/kg/day
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levothyroxine dose >12 yr
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2-3 mcg/kg/day
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