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15 Cards in this Set

  • Front
  • Back
Definition of nosocomial septicemia
-hospital acquired infections
-Approx. 15% of hosptitalized newborns (>48 h of stay in the NICU) may acquire an infection)
most common cause
-->staplyococcus (s. aureus-coagulase +, and s. epidermidis-CONS, the most common)
-->enteric gram - and p. aeruginosa
transmission of bacteria
indwelling central vascular catheters, thoracostomy tubes, or CNS shunts (staphylococcus- s. aureus and s. epideridis)
clinical manifestion
same as septicemia
therapy-antibiotic of choice
penicillinase resistant (antistaphyloccal) penicillins (nafcillin or oxacillin- bactericidal)
A.E. of penicillinase resistant penicillin (nafcillin or oxacillin)
-hypersensitivity rxns- rash to anaphylactic events
-dermatologic effects:nonallergic rash
therapy-MRSA and gram pos.
vancomycin (batericidal)
serum PEAK conc. of vancomycin
25-40 (toxicity)- not concentration dependent killing like AG
serum TROUGH conc. of vancomycon
5-15 (efficacy)-not concentration dependent killing like AG
A.E. of vancomycin
nephro, oto, red man syndrome (release of histamine=due to infusion)
Therapy-vancomycon-intermediate or vancomycin resistant enterococcus faecium (VREF)=covers gram +
Linezolid (IV)
AE of linezolid
severe: lactic acidosis, neutropenia, thrombocytopenia, and anemia
Therapy: for persistant S. aureus infection (adjunctively) (covers gram +) works synergistically
a.e. of rifampin
GI: N/V/D and cholestatic jaundice
Empiric regimen
-->once sensitivities return:
MRSA=vancomycin +/- rifampin
vancomycin-intermediate s. aureus or VRE=linezolid
-->if p. aeruginos, requires double coverage (can add ceftazidime, ticarcillin, or piperacillin)