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111 Cards in this Set

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  • Back
In the newborn exam, what are 4 things that you should ask in the History?
- Genetic history (mother + father)
- Prior pregnancies and outcomes
- Antipartum/Intrapartum events
(prenatal care, substance use, maternal illness/medications, infections like GBS HBV and HSV, preterm labor, intact vs. ruptured membranes, blood type)
- Delivery: Vaginal or Caesarian Section
What is better, a low or high APGAR score?
High
-What is considered full term in weeks for a newborn?

-What is considered pre-term?

-What is considered post-term?
Term = 37-42 weeks

Preterm = < 37 weeks

Post-term = > 42 weeks
What are normal vital signs for a newborn? (HR, RR, BP)
HR = 100-160
RR = 30-60 (with periodic breathing)
BP = 65/30 to 90/60
With a newborn physical exam, what are 3 things to look for in assessing their skin?
-Perfusion: cyanosis, acryanosis, mottling

-Birthmarks: hemangiomas, mongolian spots

- Jaundice (it's pathologic within 1st 24 hours of life)
With a newborn physical exam, what are 3 things to look for in assessing their HEENT?
Head (fontanelles, caput vs. cephalohematoma)

Eyes: red flexes, subconjunctival hemorrhage

Throat/mouth: cleft lip/palate, natal teeth
With a newborn physical exam, what are 3 things to look for in assessing their heart? (the 3 Ps)
PDAs, PACs, pulses:

Murmurs (PDA closure)

Arrhythmias (PAC's)

Cardiovascular (femoral pulses)
With a newborn physical exam, what are some things to look for in assessing their lungs?
Grunting, flairing, retracting

breath sounds - symmetry
With a newborn physical exam, what are 3 things to look for in assessing their abdomen?
- Umbilical cord: 2 arteries - 1 vein

- Omphalocoele or gastroschisis (intestines poking out of belly button)

- Anus: patent (open) or imperforate (no butthole or blocked butthole)
With a newborn physical exam, what are things to look for in assessing their genitalia? (male, female... other... yeah)
males: hypospadius (undescended testes)

Female: vaginal discharge

Ambiguous genitalia... seriously... yikes
With a newborn physical exam, what are things to look for in assessing their hands/feet/hips/clavicle?
Hips: ortolani/barlow maneuvers (DHD)

Feet/hands: Clubfoot, metatarsus adductus, polydactyly (extra digits), syndactyly (webbed digits)

Clavicle fracture with trauma
With a newborn physical exam, what are things to look for in assessing their neurologic function? Including spine/back?
-Tone, reflexes, nerve palsies (brachial plexus)

-Jitteriness, irritability

-Spine/back: sacral dimple
How frequent are major congenital abnormalities in newborns (% of live births, % of perinatal/neonatal deaths)?

-What are some examples of dysmorphologies/syndromes?
1.5% of live births have major congenital defects.
15-20% of perinatal/neonatal deaths due to this.

-Ex. Trisomy 21, neural tube defects
What are 3 examples of prophylactic measures for newborns?
- Ophthalmic prophylaxis
- Vitamin K (prevents hemorrhagic disease of newborn)
- Hepatitis B Vaccine (add HBIG if mother is HbsAg (+) withing 12 hours)
Name 2 examples of newborn screening?
-Oto-acoustic emissions (OAE)

-Newborn metabolic screening
(PKU, hypothyroidism, galactosemia, hemoglobinopathies). FYI: in 2006 expanded to 36 disorders!... Utah added Cystic Fibrosis in '09.

-Repeat at 2 weeks
Name some benefits of breast feeding for newborns?
- They get host resistance factors (IgE, IgA)
-Decreases URI, GI infections in infancy
-Enhances neurodevelopment outcome
What's normal weight loss for a newborn? When should they return to normal birthweight?
- up to 7-10% is acceptable

- should return to birthweight by 2 weeks
Upon discharging a newborn from the nursery, what are 4 things you should make sure the patients know?
- Umbilical cord care

- Sleep position (back to sleep!)

- Car seat... rear facing back seat

- 1st routine office appointment at 2 days... then 2 weeks
What's the most common organism that causes neonatal sepsis? What are some other causes?
-Group B Streptococcus

- E. Coli, strep viridans, staph aureus, enterococcus
What are some risk factors for neonatal sepsis? (~6 things)
- Prematurity
- Prolonged rupture of membranes (>18 hrs)
- Maternal fever
- Maternal GB strep carriage

- Hx of prior infant with GB strep disease
- Increased risk with multiple births (twins/triplets)
What's the presentation of neonatal sepsis?

-What's the mortality rate of GBS sepsis?
- Usually w/in 12-24 hours of birth
- Respiratory distress
- Poor perfusion/hypotension
- Temperature instability
- Lethargy or hypotonia
- Apnea
- Poor feeding

- (GBS) septis mortality = ~5%
What will the lab reports show in neonatal sepsis?

- What is the definitive Dx?
- increased WBC (>30,000) or decreased (<10,000)
- Increased ratio of immature to mature neutrophils
- Absolute neutrophil count (ANC <1,000)
-Thrombocytopenia
- Ches X-Ray: Infiltrates (pneumonia)

- Definitive Dx = (+) blood culture
What's the Tx for neonatal sepsis?
Ampicillin + gentamicin
How frequent does jaundice occur in preterms?
- what percentage of infants are affected in 1st week of life?
-At what serum level is jaundice noted?
- Where does it start on the body and how does it progress?
80% of the time
- 65%
- 5 mg/dl
- Starts on the head, progresses inferiorly
What presentation in a newborn would merit an evaluation for SEVERE jaundice?

-What lab values would merit this?
-Jaundice in FIRST 24 hours of life
- if persists beyond 2 weeks
- If any ill infant then gets jaundice

- bilirubin increases 5 mg/dl in 24 hrs
- Serum bilirubin > 15 or direct bilirubin > 1 mg/dl
What's the Tx for jaundice?

- Why treat?
Phototherapy... can also do an exchange transfusion (if bilirubin is > 20-25)

- to avoid kernicterus (bilirubin encephalopathy)
Outside of treatment, what can you recommend to manage jaundice?
- More frequent feedings (8-12 times daily)

ALSO: monitor and therapy using the Bhutani nomogram
Give 2 major problems arising from an infant from a mother with diabetes?
- Macrosomia (large sized baby)

- Hypoglycemia (due to acclimation of higher glucose and insulin levels in utero)

OTHERS: hypocalcenemia, polycythemia (high [hemoglobin] in blood)
Name a few difficulties that a premature child can have?
- Difficulty maintaining their temperature
- hard to control respiration (apnea)
- surfactant production is low...
- holes in heart (PAD, PFO, etc)
- poor suck, swallow and breathing
- poor renal function
- poor cerebral vasculature
- more susceptible to infection
What is Transient Tachypnea of the newborn (TTN)?
-What's its Sx, CXR findings, Tx, prognosis?
Retained amniotic fluid

Sx: respiratory distress first breaths of life
CXR: fluid in interlobar fissures
Tx: O2 support
Resolves w/in 12-24 hrs.
What's Hyaline membrane disease (HMD)?
- Sx?, CXR findings?, Tx?
It's surfactant deficiency.

Sx: respiratory distress in premature infants
CXR: "Ground-glass" appearance
Tx: O2 support, mechanical ventilation, and surfactant
What's Bronchial pulmonary dysplasia (BPD)? Sx? Tx:?
Chronic lung disease that follows hyaline membrane disease and respiratory stress syndrome
Sx: persistent O2 needs
Tx: O2 support, diuretics, bronchodilators, RSV prophylaxis
What's Necrotizing entercolitis (NEC)?
Sx? Tx? CXR findings? Complications with it?
Intestinal necrosis (like my niece Chantel had) +/- perforation and affects distal ileum/proximal colon.
Sx: Abdominal distention, vomiting, bloody stools
X-ray: air in bowel wall (Pneumotosis interstinalis)
Tx: broad-spectrum antibiotics, surgery!
Complications: interstitial perforation, sepsis (mortality ~10%)
What's intraventricular hemorrhage (IVH)?
Sx:, Complications
ischemia, reperfusion and vessel rupture in areas of low cerebral blood flow.
Sx: lethargy, apnea, seizures, shock
Complications: ventriculomegaly
WRESTLE WITH THE ALGORITHM ON PAGE 77...
Okay? He told us to...
DON'T forget to work with the algorithm on page 77....
Sound good?... YOU'RE A HANDSOME MAN!
What's the criteria for SIDS?
Sudden unexpected death
- infant under 1 y.o.
- death during sleep
- unexplained after thorough evaluation including autopsy and review of Hx.
Risk factors for SIDS?
Low birth weight
- Teenage mother
- Maternal smoking/drug use
- lack of breastfeeding
- late or absent prenatal care
- low SES (socioeconomic status)
- Fam Hx
What are some things to avoid in child's sleep environment?
- Sleeping on a soft surface (pillow, quilts, comforters)
- Any loose bedding (blankets or sheets)
- Co-sleeping
- Overheating
- PUT THEM on their back! Avoid PRONE! BE supine.
what's the cause of SIDS?
Not known...

Proposed hypothesis are:
- delayed development of arousal or cardiorespiratory control (breastfed children get this)
-Airway obstruction
- Brain stem immaturity or injury
What's the relationship of APNEA and SIDS?
none really... most kids with apnea don't die from SIDS. Most kids that died from SIDS don't have a Hx of apnea.
What does positioning have to do with SIDS?
INCREASED incidence of SIDS in infants with prone positioning. So......
"Back to sleep campaign"... (man he likes to plug things).
What are some consequences of non-prone (supine) sleeping?
- No increase of aspiration
- delayed attainment of gross motor skills
- increased incidence of occipital plagiocephaly (flattening out of back of head)
Who's most affected by SIDS?
Infants 21 days - 9 months (peak of 2-4 months)
- happens mostly between midnight and 8 a.m.
What's ALTE?
- Apparent Life Threatening Events

Examples:
- RSV or bacterial infection
- Cardiomyopathies..
- gastroesophageal reflux
- seizure
- CNS infection
- Poisoning
- munchausen syndrome
What's the presentation of ALTE?
Apnea
Color change
Change in muscle tone
Choking or gagging
How do you manage ALTE?
-hospitalize for observation
- do Dx by Hx and presentation
- Create a Tx directed at underlying cause
- TEACH PARENTS CPR! prior to discharge
Is apnea home monitoring beneficial?
No proven results that it is beneficial.
What's the incidence of child abuse?
~2% of all U.S. children are abused/neglected annually

Nearly 1700 children die from child abuse every year!!!! :(

Every 10 seconds, a child is reported abused or neglected.
Name some risk factors of abusive families?
- Poverty/economic strain (SES)
- Unmarried or teen mother
- Substance abuse
- Domestic violence

FYI: 1/3 of abuse cases occur in EXTRAfamilial settings
What are some typical historical features with abuse cases?
- Discrepant Hx (Hx doesn't match up)
- Delayed seeking care
- Hx of abuse in caregiver's childhood
- Stress in caregiver's family
- Hx of caregiver losing control from child behavior
What are some clinical findings in a child that has been abused?
- Multiple stages of healing

-abraisons, alopecia (hair loss), bites, bruises, burns, dental trauma, fractures, lacerations, ligature (strangulation) marks or scars.
What's the most common manifestation of physical abuse?
Suspicious bruises

-i.e. genitals, ears don't usually get bruised. They'll have multiple bruises of varied ages and may be patterned (like belt, pinch or cord marks)
- ANY bruise in a non-ambulatory patient raises concern!
What are some signs of abusive burning on a child?

FYI: 25% of all pediatric burns are due to abuse!!!! CRAZY!
- Any burn with circumferential, sharply demarcated edges ('stocking-glove distribution)

- Absence of splash marks in an immersion burn (bath tub)

- Cigarette, curling iron type burns
What should you think of when you see a rib fracture?
ABUSE!
IMPORTANT!

What's the triad for Shaken Baby Syndrome?

What's the outcomes?
1) Severe intracranial injury
2) Retinal hemorrhages
3) with minimal or no external signs of trauma

Outcome: 1/3 death, 1/3 permanent neurological sequelae, 1/3 'normal'
What are some indications of head and skeletal trauma in an abused child?
Fractures in multiple stages of healing, and ones in specific bones (ribs, sternum, scapula, vertebrae)

- Subdural hemorrhages, retinal hemorrhages (usually bilateral)
What should you do if a child presents with skeletal or head trauma?
Obtain a skeletal survey after any suspicious fracture (repeat survey in 2 weeks)

- obtain an ophthalmology consult
What organ is most commonly injured in abdominal trauma during child abuse?
LIVER!!!!

Other organs injured are pancreas, small bowel, duodenum.
What's the 2nd leading cause of death in child abuse cases?

What type of imaging do you want to order if a child presents with this?
- Abdominal trauma (mortality approaches 50%!!!!!!!!!)

Imaging = CT scan
What do sexually abused patients present with?
NOTHING! (in 95% of patients there are no physical findings)

BUT: can have,
- STDs, Sleep disturbance, difficulty holding bladder when toilet trained, recurrent genital or anal pain, phobias, sexual behaviors... etc (pg. 95)
What are some common presentations for emotional abuse?
- Eroded child's self esteem
- Sleep disturbances, witness abuse
headache and abdominal pain, avoidance behaviors (avoids being with parent's or uncle's house... or whoever!)
What are 3 categories of child neglect?
- Emotional (no apparent child-parent attachment)
- Physical (not giving food, clothing etc)
- Medical (not providing medical care)
What is failure to thrive (FTT), and what are some presentations of it?
Someone is not providing enough nutrition to this child for their need.

- Marked growth deceleration (preservation of head circumference), loss of subcutaneous fat, Hx of social risk factors (family dysfunction, substance abuse)

- Often reverses when child is placed with a new caregiver.
What's Munchausen Syndrome?

- Who is usually the perpetrator?
"Fastitious Disorder by Proxy" Caregiver creates signs/symptoms of illness in child (like on the 6th Sense movie when they catch the mom poisoning her child)

- Mother 95% of the time
How do we manage abuse from Munchausen Syndrome?
Immediately treat physical injuries!

- Establish a safe environment
- MANDATORY reporting (child abuse hotline or a child protective service agency)
- Use non-accusatory empathic actions. Remain objective and perform a open-ended question interview.
- Investigation by social services and law enforcement
How do you prevent child abuse?
- Use home health visitor to at-risk family
- Give education to parent regarding stress situations
- Counsel mother about safe child care arrangements
- Teach child about personal privacy (private parts, good touch and bad touch)
- Educate parents about age-appropriate discipline
What is the definition of a child fever?
T (rectal) > 38 degrees C (100.4 F)
What are some causes of increased temperature?
-Rise in hypothalamic set point (infection, cancer or collagen-vascular disease can cause hypothalmus disorders...)
- Body heat production exceeds heat loss mechanisms (malignant hypothermia)
- Heat loss mechanisms are not working (ectodermal dysplasia)
- Extrinsic heat sourses (hot weather, warm bath, excessive clothing, exercise)
What's the pathophysiology of a fever?
- Infectious agent induces macrophages to release cytokines ==> endogenous pyrogen
- These interact with anterior hypothalmus ==> releases prostaglandins and other mediators
- Prostaglandins increase metabolic rate ==> heat production, rise in core body temperature
What's the most common cause of a fever in a child?
- how long does it take to resolve?
Viral infection.
- 3-4 days
At what temperature does a correlation between fever and serious bacterial infection occur?
- When temp rises over 40 degrees C
Can a fever cause brain damage?
Apparently no... weird. I though it did.
Is Matt a handsome man?
YES! Much better than Coach Roscoe...
What immediate evaluation should occur with a child presenting with a fever? (about 9 things...)
- Age>3 months
- Fever Temp>40.6 C/ 105 F
- Breathing is labored
- Inconsolable crying
- Child is difficult to arouse
- Neck stiffness/sore (Nuchal rigidity)
- Petechiae
- Convulsion with fever
- Child looks or act VERY sick!
How do you treat a childhood fever?
- Check first for potential causes
- Use antipyretic therapy (goal is just to relieve discomfort, REDUCE temp)
- Encourage more fluid intake
- Limited sponging - tepid water
What are two drugs that can be used as antipyretics?
- Acetominophen (tylenol)
- Ibuprofen (advil, motrin)
What drug should you AVOID as a fever treatment (antipyretic)?

- Why?
ASPIRIN!

- Due to Reye's Syndrome. Can enhance fever risk due to influenza or varicella
What's important for you to identify in a child with a fever?

- What are examples of this?
Serious Bacterial Infection (pg. 106)

- UTI (74%), Sepsis/bacteremia, meningitis, bacterial pneumonia, bacterial gastroenteritis, bone/soft tissue infections (osteomyelitis, septic arthritis, abscess)
What does "fever without a source" mean?
Acute febrile illness, cause of fever is not apparent after a careful Hx and examination.
What does "lethargy" mean?
Altered level of consciousness.
- Decreased eye contact or level of interaction
What are some signs of toxicity in a child?
- LETHARGY! but also... poor perfusion, cyanosis, hyper/hypo-ventillation
What does "occult bacteremia" mean?
When child isn't toxic appearing clinically, and has the presence of bacterial pathogens in blood.
What does "sepsis" mean?
Presence of bacteria in blood of a patient that is ALSO toxic!

-Different from occult bacteremia
What's a risk with hypothermia (temp < 36C)?
severe bacterial infection (SBI)
What's the correlation between an increase in fever and SBI?
As fever increases, SBI risk increases.
If a child age 1-90 days old presents with a fever and is toxic, what percentage of risk for SBI do they have?
17%
If a child age 1-90 days old presents with a fever and is not toxic, what percentage of risk for SBI do they have?
9%
If a child age 1-90 days old presents with a fever and is "low risk", what percentage of risk for SBI do they have?
1.4%
What's the Rochester criteria for low-risk infants? (page 108) ... this is stupid...
It evaluates febrile infants < 60 days old that...

- have non-toxic appearance
- were previously healthy
- No skin, soft tissue, bone, joint or ear infection noted
- have WBC: 5000-15,000 with <1500 bands (WBC count > 15,000 increases bacteremia risk 3 fold)
- Urinalysis < 10 WBC/hpf
What is the most common pathogen in severe bacterial infection (SBI) fever?
E. Coli (page 108)
How do you manage a 1-30 day old child with severe bacterial infection (SBI) fever? (3 steps)
1) Full sepsis workup
2) Hospitalize
3) IV antibiotics, pending culture results (ampicillin + cefotaxime and gentamicin)... if meningitis is suspected: triple the coverage. If just uti, then do the first two.
How do you manage a 30-90 day old child with severe bacterial infection (SBI) fever? (2 steps) [think high and low risk]
1) If doesn't meet low risk criteria:
a) sepsis work-up, hospitalize, iv antibiotics
2) If low risk
a) sepsis work-up, out patient antibiotics and follow-up in 24 hours
b) Urine culture only, outpatient observation w/ no antibiotic, follow-up in 24 hours.
If a 28-90 days old child presents with a fever, and if WBC & differential urinalysis/stool exam (if diarrhea) comes back with positive labs, what should you do next? (algorithm on page 109)
Admit them
If a 28-90 days old child presents with a fever, and if WBC & differential urinalysis/stool exam (if diarrhea) comes back with negative labs, what two options do you have? (algorithm on page 109)
Option A: Perform a urine culture, blood culture, CSF culture, give ceftiaxone and return in 24 hours
Option B: Urine culture, and observation
If a 28-90 days old child presents with a fever, and you receive a positive CSF culture, how do you manage that?
Admit them, give IV antibiotics (ampicillin + gentamicin + CEF)
If a 28-90 days old child presents, and you receive a positive blood culture, how do you manage that?
If it's S. pneumonia (non-resistant) and patient is stable (afebrile): give ceftriaxone (IM), then oral amoxicillin x 10 days
- If a different pathogen, admit, IV antibiotics (ampicillin + CEF)
If a 28-90 days old child presents, and you receive a positive urine culture, how do you manage that?
If afebrile w/o bacteremia, give oral antibiotic (cefdinir) x 10 days
- If febrile or bacteremic, admit and iv antibiotics (ampicillin + CEF)/ (ceftriaxone if > 60 days)
If a 28-90 days old child presents with a fever, and if WBC & differential urinalysis/stool exam (if diarrhea) comes back with positive labs, what should you do next? (algorithm on page 109)
Admit them
If a 28-90 days old child presents with a fever, and if WBC & differential urinalysis/stool exam (if diarrhea) comes back with negative labs, what two options do you have? (algorithm on page 109)
Option A: Perform a urine culture, blood culture, CSF culture, give ceftiaxone and return in 24 hours
Option B: Urine culture, and observation
If a 28-90 days old child presents with a fever, and you receive a positive CSF culture, how do you manage that?
Admit them, give IV antibiotics (ampicillin + gentamicin + CEF)
If a 28-90 days old child presents, and you receive a positive blood culture, how do you manage that?
If it's S. pneumonia (non-resistant) and patient is stable (afebrile): give ceftriaxone (IM), then oral amoxicillin x 10 days
- If a different pathogen, admit, IV antibiotics (ampicillin + CEF)
If a 28-90 days old child presents, and you receive a positive urine culture, how do you manage that?
If afebrile w/o bacteremia, give oral antibiotic (cefdinir) x 10 days
- If febrile or bacteremic, admit and iv antibiotics (ampicillin + CEF)/ (ceftriaxone if > 60 days)
What's the correlation with fever over 41 degrees and risk of occult bacteremia in infants 3-36 months?

- What's the common pathogen associated with a fever in this age group?
risk increases

- E. coli... again!
How do you manage a fever in a child age 3-36 months? (hint: look at it with a fever over 39 toxic and non-toxic and under 39 degrees... what do you do?)
1st: eliminate from consideration patients with obvious viral infection or those with a defined source (like Ottits Media)
-THEN: for fever < 39, evaluate, antipyretics, and follow-up
- For fever > 39: IF TOXIC (or immuniodeficient)... admit, septic work-up, IV antibiotics
IF NON-TOXIC use the screening tests! (these are described later on)
What are the screening tests used for non-toxic febrile (>39 degrees) children ages 3-36 months? (5 things)
-WBC
- Blood culture
- Urinalysis/Urine culture
- Chest X-Ray
- Stool culture
Read page 111 of syllabus to understand details of these.
What are some management decisions that you need to make with a febrile child (>39 degrees) age 3-36 months?
Get CBC... if WBC is > 15,000, obtain BCx and treat with ceftriaxone
- get Urine culture: in all females and males to check for UTI
- Get chest X-ray or stool culture if clinically indicated
IF a child age 3-36 months gets a positive blood culture, what should you do?
If afebrile with S. Pneumoniae, give ceftriaxone, then amoxicillin x 10 days
- If febrile, ill or non-S. pneumoniae: repeat blood culture, obtain CSF culture and admit for IV antibiotics
If a child age 3-36 months has a positive urine culture, what do you do?
If afebrile: oral antibiotics x 10 days

If febrile or ill: admit for IV antibiotics.
IF a child over 90 days presents with a fever over 39 degrees and a WBC count under 15,000... what would you do?
Just observe
IF a child over 90 days presents with a fever over 39 degrees and a WBC count over 15,000... what would you do?
Get a blood culture and treat with ceftriaxone.