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17 Cards in this Set

  • Front
  • Back
what chromosome are HLA antigens located on
6
what are the 6 major loci
A B C DR DQ DP
how many HLA antigens are detectable by serologic testing?
6
how many HLA antigens can be detected by molecular testing
10-14
characteristics that one looks for in a donor
younger age better
same sex
no pregnancy
CMV negative
Toxicity from DSMO
bradycardia
what is the relationship between peripheral blood stem cells and risk for chronic GVHD
risk increases b/c of greater number of mature t-cells
Donor hierarchy for stem cell transplanatation
6/6 sibling
6/6, 5/6 relative
6/6 unrelated; 6/6, 5/6 unrelated cord
4/6 unrelated cord, 5/6 unrelated
4/6 relative, 3/6 parent or relative
SE busulfan
hepatotoxic
VOD
TBI and busulfan doses in submyeloablative transplant
TBI - 200cGy
Busulfan - 8mg/kg total dose (vs 16mg/kg)
which AML subgroups would you not transplant
APML
t 8;21

b/c of better risk status
minimum cell doses to reduce risk of graft rejection
PBSC: CD34 > 2 x 10 to the 6th/kg
CB: TNC > 2 x 10 to the 7th/kg
BM: TNC > 1 x 10 to the 8th/kg
what is the chance of HSV reactivating within one month after transplant
80%
what group of bacteria are largely responsible for late infections (post neutropenic phase) after transplant
encapsulated organisms
- s pneumo
- H flu B
4 problems with T cell depleted transplants
graft failure
delayed immune reconstitution
increased risk for opportunistic pathogens
loss of graft vs tumor/leukemia reponse
risk factors for VOD
MTX GVHD prophylaxis
prior hepatic RT
second HSCT
altered pharmacokinetics of cytoxan, busulfan, etoposide in conditioning
% mortality associated with renal failure in setting of VOD
85%