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17 Cards in this Set
- Front
- Back
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what chromosome are HLA antigens located on
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6
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what are the 6 major loci
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A B C DR DQ DP
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how many HLA antigens are detectable by serologic testing?
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6
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how many HLA antigens can be detected by molecular testing
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10-14
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characteristics that one looks for in a donor
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younger age better
same sex no pregnancy CMV negative |
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Toxicity from DSMO
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bradycardia
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what is the relationship between peripheral blood stem cells and risk for chronic GVHD
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risk increases b/c of greater number of mature t-cells
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Donor hierarchy for stem cell transplanatation
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6/6 sibling
6/6, 5/6 relative 6/6 unrelated; 6/6, 5/6 unrelated cord 4/6 unrelated cord, 5/6 unrelated 4/6 relative, 3/6 parent or relative |
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SE busulfan
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hepatotoxic
VOD |
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TBI and busulfan doses in submyeloablative transplant
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TBI - 200cGy
Busulfan - 8mg/kg total dose (vs 16mg/kg) |
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which AML subgroups would you not transplant
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APML
t 8;21 b/c of better risk status |
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minimum cell doses to reduce risk of graft rejection
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PBSC: CD34 > 2 x 10 to the 6th/kg
CB: TNC > 2 x 10 to the 7th/kg BM: TNC > 1 x 10 to the 8th/kg |
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what is the chance of HSV reactivating within one month after transplant
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80%
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what group of bacteria are largely responsible for late infections (post neutropenic phase) after transplant
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encapsulated organisms
- s pneumo - H flu B |
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4 problems with T cell depleted transplants
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graft failure
delayed immune reconstitution increased risk for opportunistic pathogens loss of graft vs tumor/leukemia reponse |
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risk factors for VOD
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MTX GVHD prophylaxis
prior hepatic RT second HSCT altered pharmacokinetics of cytoxan, busulfan, etoposide in conditioning |
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% mortality associated with renal failure in setting of VOD
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85%
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