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24 Cards in this Set

  • Front
  • Back
First line of defense against pathogens
Nonspecific natural immunity
Nonspecific natural immunity mechanisms
Skin, body secretions, mucous membranes, body pH, maternal antibodies, phagocytes
Specific immunity mechanisms
Humoral response and Cell-mediated response
Humoral immune response
if antigen avoids non-specific natural mechanisms
B-cells create plasma cells--> memory cells and cell-specific antibodies
IgG
crosses placenta, secondary immunity
mature levels at 7-8 years
IgM
primary immunity response
low @birth\. increases @ 1 week and matures @1 year.
IgA
Mucous membrane immunity. Passed in breast milk, not present at birth
matures by 6-7 years
IgE
allergic response and parasitic infection.
mature @ 6-7 years
Primary immune response
IgM, 5-10 days after exposure
Secondary immune response
IgG, 3-5 days after exposure
Cell mediated immune response
T cells trigger release of cytokines to recruit more cells
targets virus, slow growing bacteria (TB), fungus, non-self antigen
T cells
CD4
CD8- killer cells, cancer and graft vs host reaction
Suppressor cell= turns off immune reaction
HIV presentation in Children
thrush, failure to thrive, lymphadenopathy, hepatosplenomegaly, parotits, developmental delays
Difference AIDS progression in Children
shorter HIV-->AIDS time, with in a year
opportunistic infection
pneumocystis pneumonia (PCP) by 2 months with vertical transmission
Diagnosis of HIV in newborns
All newborns screened with DNA-PCR
western blot not reliable bc testing moms antibodies
Stage N
Asymptomatic
or have only one indicator
Stage A
Mild
two or more of:
lymphadenolpathy
hepatomegaly
splenomegaly
dermatitis
parotitis
Upper resp infxn, sinusitis, ear infxn
Stage B
Moderate
Aneamia, neutropenia, thrombocytopenia
bacterial meningitis, pnuemonia, spesis
candidiasis, oropharyngeal
cardiomyopathy
CMV
Chronic diarrhea
herpes, hepatitis,
LIP
Leiomyosarcoma
Stage C
LIP
PCP
CMV
encepolaopathy
wasting syndrome
candida
herpes simplex
myobacterium aviaum
parasitic
HIV management
C-section w. mom , 1,000/mL, ZDV during pregnancy
@ birth, administer ZDV, and Bactrim (PCP prophylaxis) avoid breastfeeding 4-6weeks
Class of antiretroviral medications
HAART
NRTI
NNRTI
Protease inhibitors
NRTI
Nucleoside reverse transcriptase inhibitors
ZDV
DDI
NNRTI
Non-nucleoside reverse transcriptase inhibitor

nevirapine
efavirenz
Protease inhibitors
lopinavir/ritonavir
atazanavir
foasamprenavir
nelfinavir