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18 Cards in this Set
- Front
- Back
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How does atopic dermatitis present acutely? chronically?
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Acute: erythematous patchis with vesculation and weeping, possibly some crusting
Chronic: dry thickened patches and plaques, pruritis |
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What is the atopic triad?
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atopic dermatitis, asthma, allergic rhinitis
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How does atopic dermatitis change in its three age brackets?
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infantile: extensor surfaces
childhood: antecubital, popliteal fossae adolescent/adult: flexural accentuation |
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What is keratosis pilaris?
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perifollicular hyperkeratoses seen over extensor surfaces in atopic dermatitis
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What are Dennie's lines? What other eye involvement is possible in atopic dermatitis?
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an extra fold of lower eyelid due to vascular congestion in atopic dermatitis. Cataracts are also a possible complication!
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What is the cell predominance in atopic dermatitis?
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TH2!
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What leads to reduced TH1 function in atopic dermatitis?
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increased catabolism of cAMP by phosphodiesterase leads to increased released of PGE2 and IL-10 which inhibit TH1 cells
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What causes the dry skin in atopic dermatitis?
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increased transpidermal water loss
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What is the DDx of atopic dermatitis?
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seborrheic dermatitis (esp in the daiper area), contact dermatitis, psoriasis
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How do you treat atopic dermatitis?
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Topical steroids, avoid soaps and water
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What two cateogries can we divide vascular birthmarks into?
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hemangioma (vascular lesion marked by endothelial hyperplasia) and malformation (lesion with normal endothelial turnover)
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What is the progression of hemangioma?
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Appear in first 5 wks of age (not raised yet), rapid growth up to 9 months, resolves by age 12 in most cases
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What is a marker for hemangioma?
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GLUT1 expressed in placenta and brain
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How do we classify malformations?
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Based on its predominant vessel involvement
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What is Kasabach-Merritt syndrome?
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A condition associated with hemangioma where platelet sequestration results in thrombocytopenia with the risk of severe hemorrhage
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What is Sturge-Weber syndrome?
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Capillary malformation (port wine stain) in the distribution of V1 with ipsilateral meningeal and cortical vascular malformations (often associated with seizures, retardation, and glaucoma)
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What is Klippel-Trenaunay-Weber syndrome?
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ipsilateral hypertrophy of a limb in association with capillary or venous malformations (often associated with AV and lymphatic complications)
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What is PHACES syndrome?
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Posterior fossa malformations
Hemangiomas Arterial anomalies Coarctation of the aorta Eye problems Sternal clefts/Stroke! (associated with hemangioma) |
