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18 Cards in this Set

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How does atopic dermatitis present acutely? chronically?
Acute: erythematous patchis with vesculation and weeping, possibly some crusting
Chronic: dry thickened patches and plaques, pruritis
What is the atopic triad?
atopic dermatitis, asthma, allergic rhinitis
How does atopic dermatitis change in its three age brackets?
infantile: extensor surfaces
childhood: antecubital, popliteal fossae
adolescent/adult: flexural accentuation
What is keratosis pilaris?
perifollicular hyperkeratoses seen over extensor surfaces in atopic dermatitis
What are Dennie's lines? What other eye involvement is possible in atopic dermatitis?
an extra fold of lower eyelid due to vascular congestion in atopic dermatitis. Cataracts are also a possible complication!
What is the cell predominance in atopic dermatitis?
TH2!
What leads to reduced TH1 function in atopic dermatitis?
increased catabolism of cAMP by phosphodiesterase leads to increased released of PGE2 and IL-10 which inhibit TH1 cells
What causes the dry skin in atopic dermatitis?
increased transpidermal water loss
What is the DDx of atopic dermatitis?
seborrheic dermatitis (esp in the daiper area), contact dermatitis, psoriasis
How do you treat atopic dermatitis?
Topical steroids, avoid soaps and water
What two cateogries can we divide vascular birthmarks into?
hemangioma (vascular lesion marked by endothelial hyperplasia) and malformation (lesion with normal endothelial turnover)
What is the progression of hemangioma?
Appear in first 5 wks of age (not raised yet), rapid growth up to 9 months, resolves by age 12 in most cases
What is a marker for hemangioma?
GLUT1 expressed in placenta and brain
How do we classify malformations?
Based on its predominant vessel involvement
What is Kasabach-Merritt syndrome?
A condition associated with hemangioma where platelet sequestration results in thrombocytopenia with the risk of severe hemorrhage
What is Sturge-Weber syndrome?
Capillary malformation (port wine stain) in the distribution of V1 with ipsilateral meningeal and cortical vascular malformations (often associated with seizures, retardation, and glaucoma)
What is Klippel-Trenaunay-Weber syndrome?
ipsilateral hypertrophy of a limb in association with capillary or venous malformations (often associated with AV and lymphatic complications)
What is PHACES syndrome?
Posterior fossa malformations
Hemangiomas
Arterial anomalies
Coarctation of the aorta
Eye problems
Sternal clefts/Stroke!
(associated with hemangioma)