Pda2 Test 3 Set 4

Front 1

Estrogen Antagonists categories (4) and are useful in treating what?

Back 1

1)impeded estrogens
2)triphenyletyhylene antiestrogens
3)pure antiestrogens
4)SERMs

estrogen-dependent breast cancer

Front 2

Impeded estrogen ex

Back 2

estriol

Front 3

Triphenylethylene antiestrogens ex

Back 3

tamoxifen

Front 4

Pure antiestrogens characterisits

Back 4

NO estrogenic properties, just pure antagonists

Front 5

SERMs def and ex

Back 5

Activate the estrogen receptor and also have tissue-specific estrogen agonist or antagonist activity

Raloxifene (evista)

Front 6

2 types of Aromatase inhibitors and their fxn

Back 6

1)steroidal
2)nonsteroidal

block conversion of androgens to estrogens, treat estrogen-dependent breast cancer

Front 7

Steroidal Aromatase inhibitors desc.

Back 7

will be steroids themselves and try to imitate testosterone (the endogenous Aromatase substrate)

Front 8

Nonsteroidal aromatase inhibitors desc. (4)

Back 8

1)contain heterocyclic rings
2)inhibit adrenal steroidogenesis
3)produce inhibition by binding of the N atom in heterocyclic ring w/ heme iron of aromatase
4)contain highly N substituted rings

Front 9

Nonsteroidal aromatoase inhibitors ex (3)

Back 9

1)Aminoglutethimide
2)Anastrozole
3)Letrozole

Front 10

Aromatoase is considered a...

Back 10

cytochrome P450 enzyme

Front 11

Progesterone maintains...

Back 11

pregnancy

Front 12

Pregnancy is detected (in urine) via...

Back 12

the progestin 5beta-pregnandiol glucuronide

Front 13

Why are synthetic progestins needed

Back 13

b/c progestins are very unstable

Front 14

Synthetic progestin groups (3)

Back 14

1)androgen series
2)17alpha-progesterone derivatives
3)Antiprogestins

Front 15

Mechanism of Antiprogestins?

Back 15

has large group @ C11

Front 16

Synthetic Anabolic agents desc. (3)

Back 16

1)NO sex hormone properties via...
2)alpha methyl @ C17 &
3)slight A ring changes

Front 17

Androgen drug categories (2)

Back 17

1)synthetic androgens
2)19-norandrogens

Front 18

Testosterone has 2 fxns

Back 18

1)sex hormone
2)androgen

Front 19

Synthetic androgens are made that way via...

Back 19

F @ C9 and OH @ C11; destroys anabolic activity and highly increases androgenic activity

Front 20

Antiandrogens (2 classes)

Back 20

1)androgen antagonists
2)inhibitors of androgen biosynthesis

Front 21

Androgen antagonists desc

Back 21

antagonize the axn of dihydrotestosterone @ androgen receptor

Front 22

Inhibitors of Androgen biosynthesis target...(3)

Back 22

1)5alpha reductase
2)17alpha hydroxylase
3)17,20 lyase

Front 23

Uses of androgen antagonists (4)

Back 23

1)acne
2)virilization in women
3)hyperplasia of prostate
4)neoplasia of prostate

Front 24

2 5alpha reducatse inhibitors

Back 24

1)medrogesterone
2)finasteride

Front 25

Major therapeutic/structural classifications of sex hormones (6)

Back 25

1)estrogens
2)progestins
3)aromatase inhibitors
4)estrogen antagonists
5)androgens
6)antiandrogens