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27 Cards in this Set
- Front
- Back
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Adverse Effects/toxicities of alkylating agents
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Bone marrow - acute myelosuppression
Immunosuppression Intestinal mucosa Pulmonary fibrosis Nephrotoxicity - renal failure Central neurotoxicity Amenorrhea, azoospermia |
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Adverse effects of methotrexate
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Bone marrow suppression
Intestinal epithelium toxicity Nephrotoxicity Defective oogenesis or Spermatogenesis Hepatic dysfunction |
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Adverse effects of cytarabine (araC)
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Myelosuppression
GI disturbances Reversible hepatic dysfunction Seizures (neurotoxicity) |
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Adverse effects of gemcitabine
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Myelosuppression
Flu-like symptoms Asthenia Milkd elevation of liver enzymes |
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Adverse effects of mercaptopurine
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Bone marrow depression
Anorexia, nausea, vomiting Jaundice |
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Adverse effects of adenosine deaminase inhibitors
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Melosuppression
GI upset Skin rashes Immunosuppression |
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Adverse effects of fludarabine
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Myelosuppression
GI upset Immunosuppression Anorexia Neurotoxicity |
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Adverse effects of vinblastine
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Leukopenia
GI upset Hair loss |
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Adverse effects of vincristine
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Neurological disorders
Severe constipation Alopecia GI upset |
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Adverse effects of taxanes
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Neutropenia
Peripheral neuropathy Hypersensitivity reactions Asymptomatic bradycardia Ventricular tachycardia |
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Adverse effects of podophyllotoxins
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Leukopenia
Thrombocytopenia Nausea, vomiting, diarrhea Hepatic toxicity |
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Adverse effects of camptothecins
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Neutropenia
Thrombocytopenia Diarrhea, nausea, vomiting Elevated liver enzymes Myelosuppression |
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Adverse effects of anthracycline antibiotics
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Myelosuppression
Leukopenia Thrombocytopenia Anemia GI disturbances Cardiomyopathy |
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Adverse effects of bleomycin
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Cutaneous toxicity: hyperpigmentation, hyperkeratosis, erythema
Pulmonary toxicity Hyperthermia, headache, N/V |
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Adverse effects of mitomycin
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Myelosuppression
Leukopenia Thrombocytopenia N/V, diarrhea, fever Interstitial pulmonary fibrosis |
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Adverse effects of hydroxyurea
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Bone marrow depression (leukppenia, anemia, thrombocytopenia)
GI upset Rash, skin ulcerations |
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Adverse effects of bortezomib
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Peripheral neuropathy
Cardiac and pulmonary disorders Thrombocytopenia and neutropenia |
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Adverse effects of cytokines
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Hypotension, tachycardia, N/D/V, anorexia, thrombocytopenia, anemia, leukopenia, confuction and anxiety, dyspnea, rash, oliguria
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Adverse effects of L-asparaginase
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Anaphylaxis
Pancreatitus Thrombosis |
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Adverse effects of Angiogenesis inhibitors
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Sedation
Constipation Peripheral sensory neuropathy Leukopenia, hepatotoxicity, renal dysfunction (lenalidomide) |
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Adverse effects tamoxifen
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Throat irritation
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Adverse effects toremifene:
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Menopause-like symptoms, leukopenia, thrombocytopenia, cardiac dysfunction
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Adverse effects flutamide
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Diarrhea
Cystitis Procitis N/V Impotence |
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Adverse effects of anastrozole
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Skin reactions
Allergic reactions Inflammation of the liver |
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Adverse effects of letrozole
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Bone effects (pain, osteoporosis)
Increased cholesterol |
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Adverse ffects of exemestane
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Myocardial infarction, osteoporosis
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Adverse effects of mitotane
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Anorexia, N/V/D
Depression, lethargy, dizziness, vertigo |
