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188 Cards in this Set
- Front
- Back
Body organization levels from simplest to most complex:
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Chemical
Cellular Tissue Organ System Organism |
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Chemical level of body organization
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Chemical elements are composed of atoms which may be bound together to form molecules.
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Most abundant elements within body:
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Oxygen
Carbon Hydrogen Nitrogen |
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Cellular level of body organization
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Cells are the basic structural and functional components of life. The human body contains between 75 and 100 trillion cells.
|
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Cells
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Composed of cytoplasm
Must use nutrients to produce energy to survive 200 - 250 different types There's a relationship between shape and function. |
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Tissue
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Aggregations of similar cells that perform specific functions in the body.
|
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Four basic types of tissues
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Epithelial - surface covering
Connective - supportive Muscular - contracting Nervous - conduction |
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Organ
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An aggregation of several tissue types integrated to perform a particular function.
Vary greatly in size and function Ex = heart, kidneys, stomach, ovary, and each bone |
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Body System
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consists of various organs that work together to perform specific functions
Ex = circulatory, respiratory, nervous, digestive, urinary, reproductive, muscular, skeletal, immune, and endocrine systems |
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Organism
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the living individual composed of all the parts of the body functioning together.
Survival is dependent upon the normal functioning of each of its parts. All of the body systems work to provide homeostasis |
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Homeostasis
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a relative constancy of the internal environment
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Negative Feedback
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When a factor becomes excessive of insufficient, so the system which monitors that factor initiates a counter-change that returns the factor toward the normal value
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Normal range for arterial blood pH:
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7.35 - 7.43
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Normal range for glucose in blood
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80-120 mg/100 mL
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What are feedback systems composed of?
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a monitoring receptor or organ that responds to the condition of the system
Ex = thermometer A control center that receives and evaluates the information from the monitoring receptor Ex = thermostat A reactor which increases or decreases productivity and thereby regulates the system. Ex = furnace |
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Negative feedback
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Changes occurring away from a desired value that are reversed so that activity is toward restoring homeostasis.
Reverses the direction of physiological change |
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Positive feedback
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Changes occurring away from a specific value that are continually accelerated.
Continues the direction of physiological change |
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Atrophy
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A gradual decrease in the size of a tissue or organ as a result of a diminished size of its cells
Can result from disuse, decreased nutrition, denervation, lack of hormonal stimulation, or ischemia |
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Ischemia
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insufficient blood
|
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Hypertrophy
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The growth of an organ or tissue due to an increase in the size of its cells
Results from increased activity or functional demand, and is most often seen in skeletal and cardiac muscles. Increased activity of muscle cells stimulates an increase in the size and number of cellular organelles and an increase in protein synthesis |
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Hyperplasia
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Stimulated mitotic divisions in cells by increased functional demands, resulting in an increase in tissue or organ size
Ex = formation of a callus on the epidermis of the palm from excessive friction |
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Dysplasia
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Abnormal maturation of cells within a tissue resulting in variations in size, shape, and appearance of cells.
Can occur in cells exposed to chronic irritation or inflammation Can progress to neoplastic disease (tumor) |
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Metaplasia
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The transformation of one cll type to another
Epithelial cells can only change to other types of epithelial cells (same with CT) Ex = transformation of fibroblasts into collagen fibers, which aid in wound healing |
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Structure of plasma membrane
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composed of phospholipid, protein and carbohydrate molecules. Lipids provide the major barrier for movement across the membrane
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Function of plasma membrane
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Gives form to cell and controls passage of materials into and out of the cell. Transports molecules in both directions.
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Structure of cytoplasm
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Fluid, jellylike substance in which organelles are suspended and in which chemical reactions take place
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Function of cytoplasm
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Serves as matrix substance in which chemical reactions occur. Contains the intracellular waste
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Structure of endoplasmic reticulum
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System of interconnected membrane-forming canals and tubules. There are two types: rough ER and smooth ER
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Function of endoplasmic reticulum
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Supporting framework within cytoplasm; transports materials and provides attachment for ribosomes
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Structure of ribosomes
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Granular particles composed of protein and rRNA. There are two subunits which allow for the alignment of mRNA
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Function of ribosomes
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Sythesizes proteins to mainly be used within the cell. All cellular structures contain protein
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Structure of golgi apparatus
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Cluster of flattened, membranous sacs which are involved in packaging molecules for secretion from the cell and in the synthesis of carbohydrates and steriods
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Function of golgi apparatus
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Modification of proteins by adding carbohydrates; and packages molecules for secretion; secretes lipids and glycoproteins
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Structure of Mitochondria
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Membranous sacs with folded inner partitions which are involved in the production of energy
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Function of golgi apparatus
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Modification of proteins by adding carbohydrates; and packages molecules for secretion; secretes lipids and glycoproteins
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Structure of Mitochondria
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Membranous sacs with folded inner partitions which are involved in the production of energy
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Metaplasia
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The transformation of one cll type to another
Epithelial cells can only change to other types of epithelial cells (same with CT) Ex = transformation of fibroblasts into collagen fibers, which aid in wound healing |
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Structure of plasma membrane
|
composed of phospholipid, protein and carbohydrate molecules. Lipids provide the major barrier for movement across the membrane
|
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Function of plasma membrane
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Gives form to cell and controls passage of materials into and out of the cell. Transports molecules in both directions.
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Structure of cytoplasm
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Fluid, jellylike substance in which organelles are suspended and in which chemical reactions take place
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Function of cytoplasm
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Serves as matrix substance in which chemical reactions occur. Contains the intracellular waste
|
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Structure of endoplasmic reticulum
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System of interconnected membrane-forming canals and tubules. There are two types: rough ER and smooth ER
|
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Function of endoplasmic reticulum
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Supporting framework within cytoplasm; transports materials and provides attachment for ribosomes
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Structure of ribosomes
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Granular particles composed of protein and rRNA. There are two subunits which allow for the alignment of mRNA
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Function of ribosomes
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Sythesizes proteins to mainly be used within the cell. All cellular structures contain protein
|
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Structure of golgi apparatus
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Cluster of flattened, membranous sacs which are involved in packaging molecules for secretion from the cell and in the synthesis of carbohydrates and steriods
|
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Normal range for total lipids in blood
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350-850 mg/ 100 mL
|
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Normal range for urea in blood
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15-35 mg/ 100 mL
|
|
What are feedback systems composed of?
|
a monitoring receptor or organ that responds to the condition of the system
Ex = thermometer A control center that receives and evaluates the information from the monitoring receptor Ex = thermostat A reactor which increases or decreases productivity and thereby regulates the system. Ex = furnace |
|
Negative feedback
|
Changes occurring away from a desired value that are reversed so that activity is toward restoring homeostasis.
Reverses the direction of physiological change |
|
Positive feedback
|
Changes occurring away from a specific value that are continually accelerated.
Continues the direction of physiological change |
|
Atrophy
|
A gradual decrease in the size of a tissue or organ as a result of a diminished size of its cells
Can result from disuse, decreased nutrition, denervation, lack of hormonal stimulation, or ischemia |
|
Ischemia
|
insufficient blood
|
|
Hypertrophy
|
The growth of an organ or tissue due to an increase in the size of its cells
Results from increased activity or functional demand, and is most often seen in skeletal and cardiac muscles. Increased activity of muscle cells stimulates an increase in the size and number of cellular organelles and an increase in protein synthesis |
|
Hyperplasia
|
Stimulated mitotic divisions in cells by increased functional demands, resulting in an increase in tissue or organ size
Ex = formation of a callus on the epidermis of the palm from excessive friction |
|
Dysplasia
|
Abnormal maturation of cells within a tissue resulting in variations in size, shape, and appearance of cells.
Can occur in cells exposed to chronic irritation or inflammation Can progress to neoplastic disease (tumor) |
|
Metaplasia
|
The transformation of one cll type to another
Epithelial cells can only change to other types of epithelial cells (same with CT) Ex = transformation of fibroblasts into collagen fibers, which aid in wound healing |
|
Structure of plasma membrane
|
composed of phospholipid, protein and carbohydrate molecules. Lipids provide the major barrier for movement across the membrane
|
|
Function of plasma membrane
|
Gives form to cell and controls passage of materials into and out of the cell. Transports molecules in both directions.
|
|
Structure of cytoplasm
|
Fluid, jellylike substance in which organelles are suspended and in which chemical reactions take place
|
|
Function of cytoplasm
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Serves as matrix substance in which chemical reactions occur. Contains the intracellular waste
|
|
Structure of endoplasmic reticulum
|
System of interconnected membrane-forming canals and tubules. There are two types: rough ER and smooth ER
|
|
Function of endoplasmic reticulum
|
Supporting framework within cytoplasm; transports materials and provides attachment for ribosomes
|
|
Structure of ribosomes
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Granular particles composed of protein and rRNA. There are two subunits which allow for the alignment of mRNA
|
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Function of ribosomes
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Sythesizes proteins to mainly be used within the cell. All cellular structures contain protein
|
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Structure of golgi apparatus
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Cluster of flattened, membranous sacs which are involved in packaging molecules for secretion from the cell and in the synthesis of carbohydrates and steriods
|
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Function of mitochondria
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Release energy from food molecules and transform energy into ATP
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Structure of lysosomes
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Membranous sacs containing hydrolytic enzymes which are involved in the digestion of foreign molecules and worn or damaged cells
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Function of lysosomes
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Digest foreign molecules and worn and or damaged cells
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Structure of fibrils and microtubules
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Thin, hollow tubes
|
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Function of fibrils and microtubules
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Support cytoplasm and transport materials within the cytoplasm
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Structure of nucleus
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A spheroid body within a cell which is the largest organelle of the cell. It contains chromatin and a nucleolus
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Function of nucleus
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Contains the chromatin (48 chromosomes, nucleolus, and the nucleoplasm). It is the control center for all cellular functions
|
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Structure of the nuclear membrane
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Membrane surrounding nucleus, composed of protein and lipid molecules.
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Perinuclear cistern
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The narrow space between the two walls of the nuclear membrane
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Function of the nuclear membrane
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Support nucleus and control passage of materials between nucleus and cytoplasm
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Structure of chromatin
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Fibrous strands composed of protein and DNA molecules. In a differentiated cell the DNA making up the chromosomes cannot be seen as individual chromosomes because the DNA is unpacked and the genes are forming the three types of RNA.
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Function of chromatin
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Controls cellular activity for carrying on life processes. It is this material that contains the 48 chromosomes and thus the genetic material that is made up of all the cell's genes.
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Structure of nucleolus
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Dense, non-membranous mass composed of protein and rRNA molecules
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What is a cell membrane composed of?
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Phospholipids - 43%
proteins - 55% carbohydrates - 2% |
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Thickness of cell membrane
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6.5-10 nanometers
|
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Hydrophilic
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Mixing with water
Ex = polar phosphate heads of phospholipid molecules |
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Hydrophobic
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Not mixing with water
Ex = nonpolar fatty acid tails of phospholipid molecules |
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Integral proteins
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embedded in the phospholipid bilayer
involved in active transport and forming membrane |
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Phospholipid bilayer
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Forms a major barrier to a vast number of water soluble substances.
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Permeability of a cell membrane to molecules is a function of:
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1) Size of molecules
2) Solubility in lipids 3) Ionic charge of molecules 4) The presence of carrier molecules |
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Five functions of proteins in the cell membrane:
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1) Structural support
2) Transport of molecules across the membrane 3) Enzymatic control of chemical reactions 4) Receptors for hormones and other regulatory molecules that arrive at the outer surface 5) Cellular markers (antigens), which identify the blood and tissue type |
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Five functions of the carbohydrate containing molecules:
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1) Repel negative objects due to their negative charge
2) Act as receptors for hormones and other regulatory molecules 3) Form specific cell markers which enable like cells to attach and aggregate 4) Enter into immune reactions 5) Regulate tissue growth, which is normally held within certain limits of cell density. |
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How many TYPES of cells are found in the body?
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Over 200, which form 4 general types of tissues.
|
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Exocrine glands
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Secretes into a duct (external environment)
Example = sweat |
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Endocrine glands
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Ductless; secrete hormones into blood
Endocrinology = study of hormones |
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Seven methods of transport across the cell membrane:
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Diffusion
Facilitated diffusion Osmosis Filtration Active transport Pinocytosis Phagocytosis |
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Diffusion
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Passive movement of molecules from regions of higher concentration toward regions of lower concentration
Only energy source needed is the molecular motion of the molecules Ex - exchange of respiratory gases in lungs |
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Facilitated diffusion
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Carrier substances are used to speed up processes
Energy source = carrier energy and molecular motion Ex = glucose entering cell with the help of insulin |
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Osmosis
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Passive movement of solvent molecules through semi-permeable membrane due to concentration difference
Energy source is molecular motion - no ATP is required Ex = water movement through the cell wall to maintain constant turgidity of cell |
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Filtration
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Molecules are forced by hydrostatic pressure from regions of higher pressures to regions of lower pressures
Blood pressure is the energy source Ex = removal of wastes within kidneys |
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Active transport
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Molecules are transported through cell membrane by integral membrane proteins from regions of low to high concentration.
Uses cellular energy (ATP) Ex = movement of glucose and amino acids through membranes |
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Pinocytosis
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Membrane engulfs minute droplets of fluid from surroundings.
Uses cellular energy (ATP) Ex = Membrane forms vacuoles containing solute and solvent |
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Phagocytosis
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Membrane engulfs solid particles from surroundings
Energy source is cellular energy (ATP) Ex = White blood cell membrane engulfs bacterial cell |
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Aquaporins (pores)
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Form channels specific for the movement of water molecules across cellular membranes.
They greatly increase the plasma membranes' permeability to water |
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Osmolarity and normal levels
|
the osmotic pressure in the body. Normal levels for body fluids is 300 mOsm.
|
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Are pancreatic cells exocrine or endocrine?
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Both
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Peripheral proteins
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loosely bound to the surface - serve as enzymes and receptors
|
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Integral proteins
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Embedded in the phospholipid bilayer - transverse the membrane and are involved in active transport.
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Intracellular fluid (ICF)
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fluid inside the cell
|
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Extracellular fluid (ECF)
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Fluid outside the cell
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What can cross the plasma membrane without energy?
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Water, small ions (through channels), lipid solubles (like cholesterol and sex hormone steroids)
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Tonicity
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the effect the concentration of nonpenetrating solutes in the intracellular verses the extracellular fluids
|
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Isotonic solution
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extracellular fluid has the same concentration of nonpenetrating solutes as the intracellular fluid
|
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Hypotonic solution
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Concentration of extracellular fluid is LOWER than intracellular fluid. Water enters the cell, causing it to swell and burst.
|
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Hypertonic solution
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Concentration of extracellular fluid is HIGHER than intracellular fluid, so water moves out of cell, causing it to shrink and burst.
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Endocytosis
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Regions of plasma membrane fold into cell, forming packets which pinch off to produce intracellular, membrane-bound vesicles with insoluble material.
Two types: pinocytosis and phagocytosis |
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Exocytosis
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Reverse endocytosis; membrane-bound vesicles in the cytoplasm fuse with the plasma membrane and release their contents to the outside of the cell
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Sorting signal
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A unique sequence of amino acids that identifies a protein.
|
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Coat proteins
|
from the cytosol bind with another specific protein facing the outer surface of the membrane
|
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Docking markers
|
Layer under coat proteins. Known as v-SNARE's. They can link lock-and-key fashion with t-SNARE's (another protein marker found on the targeted membrane)
|
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What is contained in the nucleus?
|
Chromatin, nucleolus, nucleoplasm, and chromosomes.
The nucleus is the largest organelle of the cell. |
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Perinuclear cisterna
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the narrow space between the two walls of the nuclear membrane
|
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Nucleoplasm (karyolymph)
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Gel-like medium of the nucleus
|
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Nucleolus
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A dense, non-membranous body composed of protein and rRNA molecules.
It synthesizes and stores rRNA |
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Chromatin
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Consists of DNA and proteins called histones
|
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Endoplasmic Reticulum (ER)
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an organelle consisting of a system of interconnected membrane-forming tubules. Transports substances through the cell and provides attachment for ribosomes.
Contains enzymes necessary for catabolic and anabolic activity. |
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Cisternae
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minute tubules forming a convoluted network of membranes.
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Rough ER
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Ribosomes attached, which synthesize proteins - mainly integral membrane proteins and proteins to be secreted outside the cell.
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Smooth ER
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No ribosomes, so no protein synthesis
Involved in lipid synthesis, steroid hormone synthesis, and detoxification of alcohol, drugs, and chemicals (mainly in the liver Increased amounts of smooth ER leads to the cell's tolerance of an increased volume of drugs. |
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Ribosome
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site of protein synthesis. Each consists of a larger and smaller subunit which fit together.
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rRNA's
|
the RNA of ribosomes.
rRNA = ribosomal RNA |
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How many lysosomes do cells in the body contain?
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Between 250 and 350
|
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Proteases
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Powerful hydrolytic digestive enzymes
|
|
How many proteases have been isolated from lysosomes?
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Between 30 and 50
|
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How many different cell types are there in the human body?
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200
|
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Molecules that are relatively large can cross the plasma membrane only if...
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They are lipid soluble
|
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What does the nucleolus do?
|
Synthesizes and stores rRNA
|
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What is the smooth endoplasmic reticulum involved in?
|
Lipid and steroid production
|
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The Golgi...
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Modifies proteins
Stores, sorts, and packages products Produces lysosomes |
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What are the folds of the inner membranes of mitochondria called?
|
The cristae
|
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Excessive consumption of which vitamin causes lysosomal membranes to rupture?
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Vitamin A
|
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Where are V-Snares found?
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On the vesicle membrane
|
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A callus on the epidermis of the hand is an example of what?
|
Hyperplasia
|
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What type of RNA does the nucleolus synthesize?
|
rRNA
|
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Proteins that are being made to be transported out of the cell will most likely be found on what?
|
Rough ER
|
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An excessive intake of drugs and alcohol will cause an increase in which organelle?
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Smooth ER
|
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A ribosome is made of what type of RNA?
|
rRNA
|
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Mitochondria are found in all body cells except ___________
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Red blood cells
|
|
Rheumatoid arthritis
|
The release of enzymes by Lysosomes into the joint capsule.
|
|
How many hydrolytic proteases have been isolated from lysosomes?
|
40
|
|
How many of the 109 elements are normally found in the human tissues?
|
26 elements
|
|
The thyroid gland contains remarkably large amounts of which element?
|
Iodine - up to 3,000 time the amount of plasma. Hypothyroidism = lack of iodine
|
|
Covalent Bond
|
Atoms sharing (rather than transferring) one, two, or three electron pairs.
|
|
Ionic bond
|
The electrostatic attraction between two oppositely charged ions
Total transfer of electrons Increases atoms individual stability |
|
Anions
|
Atoms that gain electrons (and an overall negative charge)
|
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Cations
|
Atoms that lose electrons (and an overall positive charge)
|
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Hydrogen bonds
|
Result from the electrostatic interaction between a small, highly electronegative atom of a molecule and a neighboring hydrogen atom.
|
|
Organic compounds
|
All compounds containing carbon except:
CO2 - carbon dioxide CO - carbon monoxide NaCN - sodium cyanide NaHCO3 - sodium bicarbonate |
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Inorganic compounds
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compounds that do not contain carbon. Ex = water, CO2, and O2
|
|
5 characteristics of carbon:
|
4 electrons in outer shell
Can make four covalent bonds Present in a large number of compounds Only H is found more often Can bond to many different elements, but most commonly to H, O, N, and C. |
|
Four major classes of organic compounds
|
1. Nucleic Acids
2. Proteins 3. Carbohydrates 4. Lipids |
|
Functions of nucleic acids (DNA and RNA)
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Storage, transmission, and expression of genetic code
|
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Functions of proteins (fibers, enzymes, hormones, macromolecules, and nitrogeneous compounds):
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Cellular structure and promote and regulate body activities
|
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Functions of carbohydrates (starches and sugars)
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Cellular fuel, storage of energy, and component of other substances, such as nucleic acids and mucopolysaccharides
|
|
Functions of lipids (neutral fats, phospholipids, and steroids)
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Storage of energy, insulation, structural support, component of cell membranes, and promote body activities.
|
|
Nucleic Acid
|
A molecule composed of nucleotides containing a nitrogen-containing base, a 5-carbon sugar, and a phosphate group
|
|
Phosphodiester linkages
|
Linkages that attach a chain of nucleotides through dehydration synthesis
|
|
Pyrimidines
|
Single ring nucleic acid compounds such as cytosine, thymine, and uracil
|
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Purines
|
Double ring nucleic acid structures such as adenine and guanine.
|
|
DNA Base Parings
|
C-G (3 hydrogen bonds)
A-T (2 hydrogen bonds) |
|
RNA Base Parings
|
C-G (3 hydrogen bonds)
A-U (2 hydrogen bonds) |
|
What serves as the blueprints of a cell?
|
Nucleic Acids
DNA RNA that is transcribed from DNA |
|
Differences between DNA and RNA
|
1) RNA has U instead of T
2) In DNA, second carbon lacks oxygen molecule, so "deoxy" 3) Three types of RNA, only one type of DNA 4) DNA = double strand, RNA = single strand 5) DNA function = genetic material, RNA function = Protein synthesis |
|
mRNA (messenger RNA)
|
Template for protein synthesis
mRNA processing: capping of a 5-methyl guanosine cap (helps ribosome bind to mRNA) and adding a long Poly-A (polyadenelated) tail. (protects strand of mRNA from digestive enzymes while in cytoplasm) |
|
tRNA (Transfer RNA)
|
Carries amino acids in the cytoplasm to the ribosomes and acts as a translation molecule. Has anticodon that matches with codon of mRNA
|
|
rRNA (Ribosomal RNA)
|
forms part of the structure of the ribosomes
Ribosome = 60% rRNA and 40% protein |
|
Protein Synthesis:
|
Two major steps:
Transcription - process by which genetic information from DNA is transferred into RNA in the nucleus Translation - mRNA is made into a functional protein by ribosome and tRNA |
|
Helicase
|
Enzyme that unzips the DNA for transcription
|
|
Single Stranded Binding Proteins and Topoisomerase
|
Enzymes that help keep the DNA uncoiled.
|
|
Structure of proteins:
|
Long chains of amino acids
Character is determined by order of amino acids Can vary from 50 to 500,000 or more amino acids |
|
Differences between proteins
|
1. Number of amino acids
2. Sequence of amino acids 3. Type of amino acids |
|
9 Common functions of proteins
|
1. Form all enzymes
2. Form most hormones 3. Comprise all of the antibodies 4. Serve as receptor sites for regulatory molecules 5. Act as carrier molecules in active transport 6. Regulate concentration of osmotic solutions 7. Provide tensile strength 8. Serve as important buffer systems 9. Be metabolized to supply cellular energy |
|
What is protein composed of?
|
A long polypeptide chain
|
|
What are amino acids composed of?
|
polypeptides and proteins
|
|
Chromosome
|
Structure composed of DNA and associated proteins that carries the hereditary info of the cell or organism
|
|
Chromatid
|
One copy of a chromosome formed by DNA replication that is joined by the centromere to another chromatid. (one side or arm of chromosome)
|
|
Centromere
|
An area on the chromosome of super-coiled DNA that holds chromatids together. Also the site where the kinetochore forms.
|
|
Gene
|
A region of the DNA that codes for a specific protein or RNA. Genes are responsible for the expression of traits and synthesis of protein molecules
|
|
Allele
|
Alternative forms of the same gene. IN a diploid ell, each gene will have two alleles, each copying the same locus (position) on homologous chromosomes
|
|
Diploid
|
A cell that contains two sets of homologous chromosomes. Most cellse are normally diploid. These cells are referred to as "autosomes."
|
|
Haploid
|
A cell that contains half the number of chromosomes. THese are the gametes (sperm and ova). These cells are referred to as "sex chromosomes."
|
|
What role do chromosomes play in the process of DNA replication?
|
They are responsible for passing genetic material from one cell to another.
|