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81 Cards in this Set

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Describe the structure of Triglycerides
Have a glycerol backbone, and 3 fatty acid chains attached to each carbon in the glycerol backbone..
Steroids
Are lipids, but are circular (the structure consists of 3 hexagons and one pentagon). Examples are Cholesterol, Sex hormones, Adrenal Cortical hormones, and vitamin D derivatives
disaccharides
sucrose, maltose, lactose
polysaccharides
glycogen or starch
What can Glycerol and fatty acids join to form?
triglycerides
pH of urine =
6.0
pH of semen =
7.5
pH of blood =
7.4
pH of vaginal secretions =
acidic
molecules that have polar bonds- may contain O-H groups or S-H groups are hydro________?
philic
molecules that have long carbon chains are hydro________?
phobic
Nearnst equation
Ek = 62mV log (k+)b / (k+)a
Differentiation:
Process by which cells become specialized to carry out specific functions
Skeletal:
* Bones
* Structure, Movement
Muscular:
* Muscles
* Movement
Nervous:
* Brain (i.e. memory)
* Spinal Cord
* Nerves
* Sensory, Regulation of everything
Integument
* Skin
* Maintain body temperature
Immune / Lymphatic:
* White blood cells
* Spleen, thymus, lymph nodes and liver
Digestive:
* Mouth, esophagus, stomach, small intestine, large intestine / colon
* obtain energy and nutrients from food
What are the 11 body systems
Reproductive
Urinary
Circulatory
Respiratory
Endocrine
Digestive
Immune (Lymphatic)
Integument (Skin)
Nervous
Muscular
Skeletal
Respiratory:
* trachea, lungs
* gas exchange
Endocrine:
* Pituitary, thyroid, thymus, adrenals, pancreas, ovaries / testes (aka gonads)
* send hormones throughout the body to maintain homeostasis - regulation
Urinary:
* Kidney, bladder, urethra
* filter blood, pH balance
Circulatory:
* heart, blood vessels
* pump blood to all the body, transport of important biomolecules
Reproductive:
* Female: Mammary gland, ovary, ovarian tubes, uterus, vagina
* Male: Testes, prostate, penis
Epithelial Tissue:
Tissue that forms protective barriers and line organs (i.e. skin, lining of digestive tract)
Tissue Types:
Muscle, Nerve, Epithelial, Connective.
Types of Connective Tissue
blood, bone, cartilage and adipose
Largest cell
Nerve
Smallest Cell
Sperm
RER (rough endo reticulum) -
contains ribosomes which synthesize proteins
Ribosomes
* the site of PROTEIN SYNTHESIS
* Two populations: Free ribosomes- manufacture proteins to be used in that cell, and RER ribosomes- manufacture proteins to be secreted from cell.
SER (smooth endo reticulum)
- lacks ribosomes, proliferates in an effort to detoxify drugs, stores calcium
golgi
* Golgi apparatus is the site of protein and lipid modification, packaging and distribution
o Flattened membranous sacs
o Modifications include phosphorylation and glycosylation
Lysosomes
* Contain enzymes! that degrade cellular or extracellular debris
* Over 40 acid hydrolases have been isolated from lysosomes
* "suicide packets" which (aid in programed cell death)transport enzymes, digestion by phagocytosis, and destruction of damaged and worn organelles
Peroxisomes
* Membranous sacs containing enzymes
* degenerates potentially toxic molecules in cell
* Produces then decomposes Hydrogen peroxide.
* Changes chemical composition to water and oxygen
* deals with cell's own wastes that could be harmful to cell
Mitochondrion
* where energy for the cell (ATP) is converted from food to ATP
* Present in all body cells except red blood cells
* through kreb's cycle energy sources( proteins, lipids, carbohydrates) are oxidized into CO2 and H2O
Vault
* An Organelle in search of a definitive function
o Transport vehicle from nucleus to cytoplasm
o hypothesized to inadvertantly defend cancer cells- poliferate around nuclear envelope (many prevent anti cancer drugs from reaching the nucleus- number of vaults increases when drugs are administered)
Nucleolus
Protein and rRNA
where ribosomes are made
What organelles are found in every body cell except red blood cells?
Nucleus and mitochondria
Micro tubules
long hollow tubes made of tubulin- they coordinate cell movement, are components of cilia and flagella, serve as highways for cell transport, and form mitotic spindle fibers
Microfilaments
helical chains made of actin- they are important in cell contraction systems, and act as the mechanical stiffener in microvilli
Intermediate filaments
every other cytoskeletal component (very diverse)- generally, they provide structural support and relieve mechanical stress in cells.
Membrane protein functions:
1. Structural support 2. Transport (pores) 3. Enzymatic control of chemical reactions 4. receptors for hormones 5. cellular markers
Membrane Carbohydrate functions:
1. Repel charged objects 2. receptors 3. cell markers
Microvilli-
closely spaced finger-like projections, increase surface area for transport and absorption ex. intestine epithelial cells
Stereocilli-
long microvilli, functions: absorption (in male reproductive cell, absence=sterile), and sensory receptors (in inner ear- used for balance)
Glycocalyx-
fuzzy delicate coat of protein, glycoprotein, and or sugar residues that cover cell surface : function- protection and recognition (ex. cell marker)
Cilia-
elongated motile extensions of cell, Functions: movement of fluid and particles
* Desmosome junction:
prevents cells from being pulled apart
Hyperplasia-
stimulated mitotic divisions in cells by increased functional demands, (ex: getting callouses from weightlifting)
Dysplasia-
deranged cellular growth resulting in variations in size, cells GONE WILD (ex: tumor)
Metaplasia-
the transformation of one cell type into another-( ex. an epithelial cell transforming into a fibroblast (which secrets collagen), which aid in healing)
Pinocytosis
– small vesicles (cell drinking)
Phagocytosis –
very large vesicles (cell eating)
hyperpolarization
when membrane potential becomes even more negative than the resting potential
depolarization
movement of the membrane potential from resting toward zero
repolarization
movement of the membrane potential back to resting
Hypopolarization
when the membrane potential becomes less negative or more positive
Acetylcholine Neurotransmitters
Cholinergic Neurons
Amino Acid Neurotransmitters
Glutamate (stimulatory), Aspartate (stimulatory), GABA (inhibitory), Glycine (mostly inhibitory, but stimulatory when bind to glutamate receptor)
Amine Neurotransmitters
Norepinephrine, Epinephrine, Dopamine, Serotonin, Histamine (all derived from amino acids)
Polypeptide Neurotransmitters
Substance P, Endorphines and Enkephalins, Cholecystokinin (CKK), Antidiuretic Hormone (ADH)- pleasure neurotransmitters
Purine Neurotransmitters
Adenosine monophosphate (AMP), Adenosine triphosphate (ATP)
Gas Neurotransmitters
Nitric Oxide (NO) (made from oxygen and arginine-freely diffuses and binds to proteins in cells)
what types of cell functions do hormones alter?
* gene transcription, Protein synthesis, enzyme activation
lipophilic hormone
a hormone that can go through the membrane and can change cell function directly. It needs a carrier in the blood cause water and lipids don't mix
lipophobic hormone
a hormone that binds on a receptor outside the cell. A protein that instigates a second messenger response to do the work and not the actual hormone.. ( ex. cAMP, and IP3, Ca++) A lipophobic hormone is usually a protein
What second messenger does glucagon cause to be made?
it causes adenilate cyclase to convert ATP into cAMP. As a second messenger, cAMP can cause enzyme activation, enzyme synthesis, or cell secretion
What second messenger does epinephrine cause to be activated?
it causes the release of IP3, which, in turn mobilizes Ca++. As a second messenger, Ca++ causes enzyme activation and cell secretion.
What contains 40 hydrolyses?
lysosomes
Which is smaller, a polypeptide or a protein?
polypeptide
What system is not entirely concerned with maintaining homeostasis?
reproductive system
What two systems are most concerned with homeostasis?
nervous and endocrine systems
What is the driving force of the body's reactions?
homeostasis
What is a desmosome junction?
they anchor cells together because they are made up of filaments that are bound to the membranes,
for strength
are steroids lipophilic or phobic?
philic
do platelets secrete prostacyclin?
no
are antibodies proteins?
yes
What doesn't the filtrate pass through?
podocyte plasma
Where is the Na/K pump located in tubular cells?
in the basolateral membrane