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65 Cards in this Set
- Front
- Back
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Imatinib
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Targeted anti-cancer agent
Small molecule tyrosine kinase inhibitor |
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Nilotinib
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Targeted anti-cancer agent
Small molecule tyrosine kinase inhibitor |
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Dasatinib
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Targeted anti-cancer agent
Small molecule tyrosine kinase inhibitor |
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Gefitinib
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Targeted anti-cancer agent
Small molecule tyrosine kinase inhibitor |
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Erlotinib
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Targeted anti-cancer agent
Small molecule tyrosine kinase inhibitor |
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Lapatinib
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Targeted anti-cancer agent
Small molecule tyrosine kinase inhibitor |
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Crizotinib
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Targeted anti-cancer agent
Small molecule tyrosine kinase inhibitor |
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Vandetanib
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Targeted anti-cancer agent
Small molecule tyrosine kinase inhibitor |
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Axitinib
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Targeted anti-cancer agent
Small molecule tyrosine kinase inhibitor |
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Trastuzumab
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targeted anti-cancer agent
tyrosine kinase inhibitor antibody to epidermal growth factor receptor |
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Cetuximab
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targeted anti-cancer agent
tyrosine kinase inhibitor antibody to epidermal growth factor receptor |
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Panitumumab
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targeted anti-cancer agent
tyrosine kinase inhibitor antibody to epidermal growth factor receptor |
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Vemubafenib
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targeted anti-cancer agent
serine-thronine kinase inhibitor |
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Sorafenib
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targeted anti-cancer agent
multi-kinase inhibitor |
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Everolimus
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targeted anti-cancer agent
mTOR inhibitor |
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Temsirolimus
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targeted anti-cancer agent
mTOR inhibitor |
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delta aminolevulinic acid
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photodynamic agent causes DNA damage and necrosis of cancer cells
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porfirmer sodium
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photodynamic agent causes DNA damage and necrosis of cancer cells
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Cyclophosphamide
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covalent modifier of DNA
alkylating agent hemorrhagic cystitis by acrolein metabolite |
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carmustine
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covalent modifier of DNA
nitrosurea |
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lomustine
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covalent modifier of DNA
nitrosurea |
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semustine
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covalent modifier of DNA
nitrosurea |
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streptozotocin
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covalent modifier of DNA
nitrosurea |
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cisplatin
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covalent modifier of DNA
platinum compound does NOT cause myelosuppression renal and acoustic nerve toxicity |
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mitomycin
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covalent modifier of DNA
forms alkylating groups in hypoxic cells VERY toxic- CHF, interstitial pneumonitis, renal failure, myelosuppression |
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Methotrexate
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antimetabolite
folic acid antagonist dihydrofolate reductase inhibitor |
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Mercaptopurine
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antimetabolite
purine antagonist/ analog |
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Thioguanine
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antimetabolite
purine antagonist/ analog |
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Fludarabine
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antimetabolite
purine antagonist/ analog |
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Cladribine
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antimetabolite
purine antagonist/ analog |
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Clofarabine
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antimetabolite
purine antagonist/ analog |
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Pentostatin
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antimetabolite
purine antagonist/ analog |
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azacytidine
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antimetabolite
pyrimidine antagonist/ analog |
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capecitabine
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antimetabolite
pyrimidine antagonist/ analog |
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cytarabine
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antimetabolite
pyrimidine antagonist/ analog |
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flurouracil
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antimetabolite
pyrimidine antagonist/ analog |
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fluorodeoxyuridine
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antimetabolite
pyrimidine antagonist/ analog |
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gemcitabine
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antimetabolite
pyrimidine antagonist/ analog |
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etoposide
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topoisomerase II inhibitor
epipodophyllotoxin acute non-lymphocytic leukemia |
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teniposide
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topoisomerase II inhibitor
epipodophyllotoxin |
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doxorubicin
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topoisomerase II inhibitor
anthracycline |
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daunorubicin
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topoisomerase II inhibitor
anthracycline |
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idarubicin
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topoisomerase II inhibitor
anthracycline |
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topotecan
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topoisomerase I inhibitor
camptothecin |
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irinotecan
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topoisomerase I inhibitor
camptothecin |
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Vinorelbine
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mitotic spindle poison
Vinca alkaloid |
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Vincristine
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mitotic spindle poison
Vinca alkaloid peripheral neuropathy |
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Vinblastine
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mitotic spindle poison
Vinca alkaloid |
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Paclitaxel
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mitotic spindle poison
Yew alkaloid |
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Docetaxel
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mitotic spindle poison
Yew alkaloid capillary leakage |
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idarubicin
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mutagenic antibiotic
anthracyclin |
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doxorubicin
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mutagenic antibiotic
anthracyclin |
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daunorubicin
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mutagenic antibiotic
anthracyclin |
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valrubicin
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mutagenic antibiotic
anthracyclin |
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epirubicin
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mutagenic antibiotic
anthracyclin |
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Amscrine
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mutagenic antibiotic
intercalation into DNA, double strand breaks |
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Dactinomycin
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mutagenic antibiotic
intercalates into DNA, inhibits DNA/RNA sx |
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Bleomycin
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mutagenic antibiotic
Binds Fe and O2, P450 reductase makes reactive species= DNA strand breaks. DOES NOT suppress bone marrow anaphylactic rxns, pulmonary fibrosis |
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Hydroxyurea
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Inhibits ribonucleotide reductase, decreasing DNA sx, reduced levels of dNTPs makes cells more sensitive to nucleoside analog drugs
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asparaginase
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Breaks down asparagines into NH3 and aspartic acid. Childhood leukemia cells can’t make their own asparagines so inhibits protein sx. MUST give after other chemo agents b/c if inhibit protein sx, stops production of targets for other chemo drugs
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pegaspargase
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Polyethylene glycol conjucated version of asparaginase. less allergenic
Breaks down asparagines into NH3 and aspartic acid. Childhood leukemia cells can’t make their own asparagines so inhibits protein sx. MUST give after other chemo agents b/c if inhibit protein sx, stops production of targets for other chemo drugs |
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Allopurinol
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reduce uric acid by inhibiting xanthine oxidase. Dead cells cause release of DNA which is metabolized to uric acid and causes gout. Purine bases are more soluble than uric acid.
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Leucovorin
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detoxify methotrexate
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GM-CSF
G-CSF |
GM-CSF (Sargramostim, LEUKINE): restore neutrophils, eosinophils and macrophages destroyed by chemo
G-CSF (filgrastim, NEUPOGEN): restore neutrophils decreased by chemo |
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Anthracyclin toxicities
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acute arrhythmias, irreversible cardiomyopathy, heart failure, extravasation necrosis, delayed skin cancer, erythema of skin exposed to x-rays.
idarubicin, doxorubicin, daunorubicin, valrubicin, epirubicin |
