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34 Cards in this Set

  • Front
  • Back

What are the main functions of the renal system?

Filtration, fluid balance, reabsorption, balance potassium

How is fluid balance regulated by the renal system?

Thirst, ADH, elevated k triggers release of aldosterone

What is normal urine output, and urea, oliguria, polyuria?

Normal-1500 mls per day or 0.5 ml per kilogram per hour



Anuria-less than 100 mls per day



Oliguria-100 to 400 ml per day



Polyuria-greater than 2,500 mls per day

What electrolytes are affected during an acute kidney injury?

Potassium, magnesium, phosphate


(Remember that K and mag go together)

What are the risk factors for developing an acute kidney injury?

Elderly


Females are at greater risk than men


Heart failure


Elevated BMI


COPD


Sepsis


Rhabdomyolysis


Contrast dye


Hypotension

Is creatinine an early or late symptom of renal failure?

Creatinine is considered a late indicator do to a 12-hour lag time

What labs will be reviewed in a patient with an acute kidney injury?

BUN (measures waste)



Creatinine (tell you what happened 12 hours ago)



Glomerular filtration rate



Proteinuria



Casts (tubular death)



Urine electrolytes (sodium)


How is the glomerular filtration rate estimated?

By creatinine clearance



Normal clearance 80-120 ml/min

What is a postrenal AKI?

Always think obstruction (urethral obstruction, prostatic disease, infection, neurogenic problems)

What can cause a prerenal Aki?

Always think low blood flow



Hypoperfusion, sepsis, heart failure, trauma, severe hypovolemia


Urine NA <10 mEq/L

What are the three types of renal failure?

Prerenal, post renal, intrarenal or ATN

What is acute tubular necrosis?

Often called intrarenal, always think damage to renal tubes







What is toxic acute tubular necrosis (ATN)

It is caused by either drugs or bacteria and is considered reversible!


remember that you would rather have toxic ATN rather than ischemic

What is ischemic acute tubular necrosis? (AtN)

The regular damage along tubular membranes, tubular cell damage in cast formation, poor kidney perfusion recovery is typically greater than 8 days

What are the three phases of acute tubular necrosis (ATN)?

Oliguric, diuretic, and recovery phase

What happens in the first phase of acute tubular necrosis?

Called the oliguric phase insult to injury occurs within 48 hours, and ability to excrete fluids or metabolic waste.



significant increase in BUN and creatinine


urine sodium < 10 mEq/L



often requires dialysis

What is the second phase of acute tubular necrosis?

Diuretic phase



Last 7 to 14 days



Will have gradual improvement in renal function



Urine output is 2-5 L/day



Monitor sodium and potassium very closely during this phase



GFR- 80-120

What electrolytes do you want to monitor closely during the diuretic phase of acute tubular necrosis?

Potassium and sodium

What patients are at risk for contrast-induced nephropathy?

Diabetics, chronic hypertension, pre-existing renal insufficiency, dehydration

What is the best prevention and treatment for contrast-induced nephropathy?

Hydration

What are the indications for dialysis?

Acid base imbalance, electrolyte imbalances (hyperkalemia), intoxication such as overdose, fluid overload, uremic symptoms

What are the laboratory findings for the need of dialysis?

BUN>35


Creatine >4


Potassium>6.5


Uncompensated metabolic acidosis

What are the best renal protection against injury?

Adequate hydration, adequate perfusion, stop nephrotoxic medications (vanc, gentamicin, it large amounts of antibiotics).

What lab findings would you expect with chronic kidney disease pts?

Anemia


Increased BUN/creatinine/PO4


Decreased calcium/HCO3/protien

What are some of the risk factors for chronic kidney disease?

Diabetes


HTN


Autoimmune disease


Systemic infection

What are possible emergent dialysis options?

Hemodialysis


CRRT


Peritoneal dialysis

What is dialysate made of

Bicarbonate and sodium W/ electrolytes

Complications of hemodialysis

Hypertension, and China, dysrhythmia, fever, thrombocytopenia, disequilibrium syndrome

What are the signs and symptoms of venous air embolism and hemodialysis?

Shortness of breath, chest pain, acute right heart failure

What is the treatment for an air embolus hemodialysis?

Lay patient on their left side Trendelenburg position, give 100% of 2

What type of dialysate is used in peritoneal dialysis?

Is a glucose base dialysate

What are the complications to peritoneal dialysis?

Peritonitis, hyperglycemia, diaphragm pressure, pleural effusion, visceral hernia or perforation

What are the contraindications for peritoneal dialysis?

Recent abdominal surgery, adominal adhesions, need for emergent dialysis

What are the normal renal lab values?

Bun- 5-20


Creatinine- 0.6-1.2


Urine specific gravity- 1.010-10.02


Urine osmolality- 300-1200


Urine sodium-27-287


Urine creatinine-1-2