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24 Cards in this Set
- Front
- Back
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Whats Ig deficiency can predispose to infection even when the total IG concentration is normal?
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IgG subclass deficiency
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Recurrent infection may be a defect in what step?
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Phagocytosis
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Hich Ig deficiency is associated w/ atopy and airway reactivity
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Ig A
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Which virus causds post transplant lymphoproliferative d/o?
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EBV
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?? what 4 markers increase nasal resistance by causing inflammation, vasodilation, and venous sinus congestion.
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Histamine, bradykinin, leukotrienes, and prostaglandins
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Antagonists of these ?? specific mediators and nasal corticosteroids reduce inflammation and nasal resistance. ?? kind of medications decrease nasal resistance by causing vasoconstriction.
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Histamine, bradykinin, leukotrienes, and prostaglandins ; Sympathomimetic
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Particles of ? size micrometers deposit in larger conducting airways and require mucoliary clearance?
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5-10 micrometers
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Where are the most sensitive cough receptors and highest densities located?
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Larynx, trachea, bronchi
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Vasodilation leads to hyperemia and is mediated by what 3 inflamm markers?
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Bradykinin, histamine, C3a and 5 a****
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What’s sequence of inflammation following injury?
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Vasodilation-> hyperemia (by bradykinin, histamine, C3a and 5), ten increased vascular permeability w/ exudative fluid, then neutrophil migration
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What 6 mediators reduce the inflammatory response? (anti-inflammatory mediators**)?
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IL -4,13, 10; TNF alpha; IL receptor 1 antaganost; TGF beta
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Which markers are pro-inflammatory**?
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TNF alpha; IL 1 beta, 8,12; IFN gamma
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Phagocyticc defenses are mediated by what cells?
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Pulmonary macrophages and recruited PMNs
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Innate immune cells express what? To orchestrate phagocytosis-dependent immune responses
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Toll like receptors
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Whats is the primary immunce cell of the resp tract?
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Alveolar macrophages
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Which cell is responseible for phagocytosis of irritants, micro-organisms, and cellular debris?
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Alveolar macrophages
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Which inflammatory product of macrophages come from enzymes?
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Lysoszyme, acid hydrolase and netural hydrolase
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Which inflammatory product of macrophages come from arachidonic acid metabolites
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Prostaglandins, thromboxane, leukotrienes
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Which inflammatory product of macrophages come from reactive oxygen metabolites?
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Superoxide anions, Hydrogen peroxide, hydroxyl radicals
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Which cytokines are are product of macrophages that are pro-inflammatory?
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Complement; IL 8,12, TNF alpha, GMCSF; T cell growth factors; IL 1,6
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What other bioactive peptides are inflammatory products of macrophages: ?
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Endothelin, defensins, fibronectin
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Which factors contribute to neutrophil chemotaxis?
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LPS, IL 1,8, TNF alpha; C3, 5 degradation; leukotriene B4
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Which chemokine is the major cytokine in eosinophil chemotaxis and maturation?
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IL 5**
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After immune stimulus, what doe eosinphils degranulate to release?
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Eosinophil granular proteins (Major basic protein); arachidonic acid metabolites; reactive O2; intermediates, cytokines,peptide mediators (substance P, VIP)
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