Pbd Quiz 6--2Nd Stack

Front 1

Inflammatory joint disease is commonly termed ______.

Back 1

arthritis

Front 2

What's IJD characterized by?

Back 2

inflammatory damage or destruction of synovial membrane, articulating cartilage AND by systemic signs of inflammation.

Front 3

What's the 2nd most common form of arthritis?
How many people does this effect?

Back 3

Rheumatoid arthritis
1.3 million Americans

Front 4

Rheumatoid arthritis is a _____ _______ ______ ______ disease.

Back 4

chronic systemic progessive autoimmune

Front 5

Rheumotoid arthritis is a ___________ group of disorders in which inflammation of _________ joints is a major manifestation.

Back 5

heterogenous
multiple

Front 6

Many patients have _______ manifestations with the most common manifestation of ____ ________

Back 6

systemic
joint involvement

Front 7

In Rheumatoid arthritis, patients have _______ _______ of ________.

Back 7

fibrinoid necrosis of
collagen

Front 8

R.Arthritis is characterized by joint ________ and _________.

Back 8

deformities
disabilities

Front 9

R.Arthritis occurs most frequently in women (___:___ female:male) during _______ years.

Back 9

2&1/2-3:1
childbearing years

Front 10

Onset of R.Arthritis is _____ or may be _____.

Back 10

insidious
acute

Front 11

RA occasionally goes into ______ ________, indicating that one can restore some type of _________ with intervention.

Back 11

remission spontaneously
balance with intervention

Front 12

If shown a picture of a joint that's effected by RA, one would see what?

Back 12

inflamed synovium, pannus, loss of cartilage, fibrous tissue (ankylosis) and pannus-filled erosion?

Front 13

Etiology of RA includes no single agent that's responsible. It can be a combination of _______ and _________.

Back 13

genetics and environment

Front 14

What's the coding system called that tells if you're susceptible to RA?

Back 14

HLA system

Front 15

T/F? RA appears to be an immune response initiated by an antigen.

Back 15

true

Front 16

What are some possible sources of this antigen for RA?

Back 16

==EBV (Epstein-Barr virus)
==Parvovirus infection (small DNA viruses)
==bacteria or microplasms

Front 17

Eventually normal antibodies somehow become __________.

Back 17

autoantibodies

Front 18

These tranformed autoantibodies are termed ____________--antibodies against ____, ____, ____ and form _______________.

Back 18

rheumatoid factors (RF's)
IgG, IgM, occas. IgA and form immune complexes.

Front 19

T/F? Some of the immune complexes that form in the RA response include activation of T helper cells and the release of cytokines.

Back 19

true

Front 20

RA main be due to some _______ immune responses to an unidentified antigen in genetically susceptible individuals.

Back 20

aberrant

Front 21

T/F? The release of cytokines or T helper cells eventually gets antibody formed to react with fragments from what were normal antibodies?

Back 21

true

Front 22

____ bind with their target self antigens in blood and form complexes in blood and _ _________.

Back 22

RF's
synovial membranes

Front 23

What type of injury is this called?
This has ________ __________ of antigenic material to stimulate the immune response.

Back 23

type III
continual production

Front 24

_____ antibodies also have been demostrated in synovial fluid in patients with RA

Back 24

Anti-collagen

Front 25

Synovial inflammation is also termed ________.

Back 25

synovitis

Front 26

2 aspects of synovitis include:

Back 26

synovial fluid
synovial membrane

Front 27

Synovial fluid phase is comprised predominantly of _____.

Back 27

PMN's

Front 28

PMN's _____ immune complexes in RA and release ______.

Back 28

phagocytize
mediators

Front 29

_____ is in constant supply, unlike other microorganisms.

Back 29

RF

Front 30

In the synovial membrane of RA, there is ____a______ infiltration with ___b______ cells and a striking accumulation of new blood vessels (termed ____c_____)

Back 30

a) perivascular
b) mononuclear
c) angiogenesis

Front 31

Synovial membranes ultimately form into what? (a)

This tissue is rich in what? b

Can lead to what? c

Back 31

a) forms a granulation tissue (pannus)

b)inflammatory cells that secrete enzymes and various mediators of inflam. to destroy cartilage and bone

c) eventually leads to join deformity and muscle atrophy

Front 32

Monocytes/macrophages and fibroblasts release ______ and _______ to resorb bone and connective tissue.

Back 32

proteases and chemotactic factors

Front 33

What's the term that describes the loss of functional synovial membrane vascularity DECREASING as granulation tissue and fibrosis develops called?

What does this cause? What does this stimulate?

Back 33

-hypoxemia from diminished blood flow.

-acidosis

-stimulates release of hydrolytic enzymes--gets even more damaged.

Front 34

What plays a major role in the amplification of the immune response in RA?

What does this lead to?
What does this serve as?

Back 34

-immune complexes (containing RF)

-proliverative synovitis

-chemotaxis force

Front 35

What is another source of amplification of inflammatory condition?

What does this lead to?

What else is activated?

Back 35

-PMN's

-leads to aggregation, degranulation, and superoxide anion generation

-other inflammatory pathways are activated (HF, kinins, complement)