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9 Cards in this Set
- Front
- Back
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What is the main phase I oxidation of drugs?
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Cytochrome P450 in liver
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What happens in biotransformation?
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Metabolizing reaction that converts a substance in the body to a more polar hydrophilic state for excretion in the urine
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What is a Phase I reaction?
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Reactions result in relatively minor chemical modification of the parent compound.
May result in the formation of functional groups which serve as sites for conjugation reactions. Generally, the metabolite formed is more polar (more water soluble; less lipid soluble) |
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WHat is a PHase II reaction?
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Conjugations- synthetic reactions with addition of another molecule.
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What type of medications undergo a hydrolysis reaction?
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Ester and Amide
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What medications undergo reduction reaction?
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azo and nitro
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What type of reactions does the Cytochrome P-450 cause?
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An oxidation reaction- a mixed-function-oxidase- dependant on NADPH and O2
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What is the abbreviation for cytochrome P-450?
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CYP
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What is the only requirement of a CYP reaction?
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It MUST be lipid soluble
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