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10 Cards in this Set
- Front
- Back
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What keeps the membrane of the lysosome from being degraded by hydrolytic enzymes?
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Specialized proteins which are glycosylated on the luminal surface of the membrane:
- lamps (lysosome-associated membrane proteins) - limps (lysosomal integral membrane proteins) - lgps (lysosomal membrane glycoproteins) |
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Three types of autophagy
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- macroautophagy
- microautophagy - chaperone-mediated direct transport (proteins transported to lysosome by hsc73) |
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Tay-sach's disease is a _________ disorder.
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Lysosomal
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What is Tay-Sach's disease?
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A lysosomal galactosidase is absent in neurons, producing lamellated structures in residual bodies that accumulate in the cell (the lysosome can't break 'em down), interfering with normal function.
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Another name for COP proteins
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coatemers
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Protein secretion pathways from the Golgi
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- Constitutive to the apical plasma membrane
- Constitutive to the basolateral membrane - To endosomes and lysosomes - To apical cytoplasm |
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Constitutive pathway from golgi to apical plasma membrane
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- non-clathrin vesicles
- sorting signal (linear arrays of aa or associated glycostlations) attached in TGN |
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Constituitive pathway from golgi to basolateral membrane
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- Sorting signal attached in TGN
- Vesicles coated with epithelium-specific adaptor prot |
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Pathway from golgi to endosomes and lysosomes
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- proteins bear M-6-P tag
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Pathway from golgi to apical cytoplasm
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aggregated or crystallized in TGN b/c of changes in pH and [Ca++]
sorted in large secretory vesicles which fuse with plasma membrane, releasing contents |
