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13 Cards in this Set

  • Front
  • Back
Types of infectious agents
Prions, Viruses, Bacteria, mycoplasma, Fungi, protazoa, helminthes,
Typical basic response to viruses
lymphocytes and monocytes.
Cell mediated defenses to control localized infection
Circulating IgG to stop blood born
Bacteria basic response
PMNs +/- necrosis
Examples of virulence factors
1 Rapid replication. Abscess results

2 Toxins. Group A streptococci exotoxins disrupt tissues to allow spread. Gas gangrene due to toxins that lyse neutrophils-->extensive necrosis, numerous gram + rods, abscence of inflammatory cells

3 Resistense to phagocytosis--TB

4 Cell entry
"Incomplete" bacterial agents
Chlamydiae: contain both DNA and RNA, obligate intracellular paracites, depend on host ATP

Chlamydia pneumonia: disseminates via macrophages and monocytes, intracellular

Rickettsiae: gram negative coccobacilli, obligate intracellular--Rocky Mountain Spotted Fever
Response to Mycoplasma
induce marked lymphoplasmacytic response. Walking pneumonia, urethritis, female GTI, bind to epithelial cell suraces (respiratory and genital)
Fungi type response
cell-mediated, varies. granulomas for histoplasma, PMNs for blastomyces
Protazoa response
variable, including hypersensitivity and/or chronic inflammation
Helminths response
induce eosinophilia in infected tissues
Nonspecific defenses
nutrition, age, fever, hormones (pregnant women get fungus)
Repertoir of Specific responses to infectious agents

necrotizing tissue damage without inflammation (clostridium, entamoeba, hep b, hsv encephalitis)

Chronic inflammation and scarring


Cytopathic/proliferative (inclusions, blisters, warts, dysplasia, cancer)
most favorabile sites for microbe entry and proliferation in general
warm moist mucosae
Innovative microbe methods of travel in body
HIV, measles, and RSV spread by syncytium (cell fusion)

Polio and rabies can ride neuronal axoplasm to soma

Malaria travels in RBCs to liver

EBV and CMV travel in WBCs