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4 Cards in this Set

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ATROPHY
Shrinkage of cells
Physiologic; r/t decreased work load

Pathologic; r/t denervation of muscle, diminished blood supply & nutritional deficiency
HYPERTROPHY
Increase in cell size resulting in enlargement of organs. It Mostly seen in cells that cannot divide, such as skeletal muscle (pumping iron), and cardiac muscle (hypertension). Changes usually revert to normal if cause is removed.
HYPERPLASIA
Increased number of cells in an organ or tissue. Hyperplasia may sometimes co-exist with hypertrophy.
physiologic--hormonal

compensatory--regeneration of liver following partial hepatectomy. Various growth factors and interluekins are important in such hyperplasia.
pathologic--excessive hormonal stimulation viral infection (papilloma viruses); neoplasms
METAPLASIA
Transformation or replacement of one adult cell type to another adult cell type (e.g., the change from columnar to squamous cells in respiratory tract, from squamous to columnar in Barrett esophagitis). Also occurs in mesenchymal tissue