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36 Cards in this Set

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phases of wound healing
vascular
inflammatory
proliferative
wound remodeling
vascular phase of wound healing
constriction of blood vessels
exposed collagen causes platelet/growth factor release to make a clot
constrict/collagen
inflammatory phase of wound healing
1. neurophils and marcophages clean and debriged
2.stimulate fibronectin-scaffold with collagen and elastin
3.granduation tissue is made
4.cell matrix proteins, collagen fibronectin, proteoglycans, hyaluronic acid
clean, fibro,grand,
proliferative phase of wound healing
days 10-14
fibronectin and epidermal growth make new epihelial surface made up of fibroblasts, collagen and proeoglycan
epi, fibro/col/pro
remodeling phase of wound healing
size decreased by myofibroblasts
collagen collects to make scar
scar,size
2 branches of immune system
cell mediated imumunity
humoral immunity


cell mediated immunity
lymphocytes neutrophils T cells
l,n,t
humoral immunity
antibodies , made by b lymphocytes and generate immunoglobins
cluster determinants
CD - markers on the surface of t cells
t cells
immunoglobins
antibodies, made by b lymphoctytes, on prior exposure to an antigen
types of immunoglobins
IgA, IgD, IgE, IgG, IgM
IgA
in body secretions
IgD
very low levels in blood
IgE
bound to mast and basophils for allergic response
allergic
IgG
seen in later exposure
IgM
seen in initial exposure
opsonization
antibodies recognize and coast invading cell o all phagocytic cells to engulf it
coat
DeGeorge syndrome
t cell deficiency, defective embryological development of thymus and parathyroid, heart defects, facial, low calcium, death as infant
Tcell,low calcium
selective IaA deficiency
lose IgA found indigestive and respiratory tracts, more infections
found in body secretions
bruton disease
x linked hypogammaglobulinemia, maure B cells are absent
x link, B's
wiscott aldrick syndrome
rare, x linked, deficent T cll and B cell, basterial infections, low platelet, eczema, die as infant from infection and bleeding, need marrow transplant
T & B,
adensosine deaminase ADA deficiency
autosomal recessive, immune deficiency, nucleotide, overwhelming inection and death, use gene therapy
nucleotide
severe combined immunodeficiency SCID
defective lysosomal granules, they are needed to destroy invading organisms
lyso
AIDS/HIV
retrovirus, a RNA virus that encodes reverse transcriptase to convert to DNA, kills CD4 cells
Autoimmune diseases
graves
hasimotos thyroditis
sjogren sndrome
SLE,lupus
scleroderma
thyroid,dry,butterfly,hide
hasimoos thyroditis
HYPO
sjogren syndrome
dry eyes, dry mouth, epsein bar can trigger, salivary lacrimal glands are target, atrophy
dry
SLE, lupus
autoantibodies againist DNA, RNA, antibodies form immune complexes that block circulation and deposit in tissue causing inflammatory response, rash photosensiivity, glomerulonephritis, joints, anemia, low WBC, low platelets, brain(seizure)
common: Arthritis,Rash, Kidney
inflammatory reponse, A,R,K
scleroderma
connective tissue is the target, thickened skin, loss of facial expression,loss movement/joint,hide bound
connective tissue
limited scleroderma/creast
raynauds (color change fingers),esophageal (swallowing), sclerodactly (tight skin fingers)
raynauds
hypersensitivity reactions I
hives, hay fever, rapid,local
hypersensitivity reactions II
IgM, IgG, macrophages, ABO incompatible
blood trans
hypersensitivity reactions III
antibodies form complexes, serum sickness, lupus, glomerulonephritis,
lupus
hypersensitivity reactions IV
delayed, no antibdoes, antigens are processed by macrophages 24-48 hrs, contact dermatitis, poison ivy, TB test
no antibodies, delay
transplant
HLA (human leukocyte antigens) recognition of foreign proteins that lead to rejectins - T cells are activated by the foreign MHC on the molecules of the graft
transplant rejections
hyper,acute,chronic
hyper - within mins, swell/bleed remove it
acute - within weeks, pain, swell give more immune meds
chronic - months, slow insidious failure, difficult to save