Pathophysiology/wound Healing

Front 1

phases of wound healing

Back 1

vascular
inflammatory
proliferative
wound remodeling

Front 2

vascular phase of wound healing

Back 2

constriction of blood vessels
exposed collagen causes platelet/growth factor release to make a clot

Hint 2

constrict/collagen

Front 3

inflammatory phase of wound healing

Back 3

1. neurophils and marcophages clean and debriged
2.stimulate fibronectin-scaffold with collagen and elastin
3.granduation tissue is made
4.cell matrix proteins, collagen fibronectin, proteoglycans, hyaluronic acid

Hint 3

clean, fibro,grand,

Front 4

proliferative phase of wound healing

Back 4

days 10-14
fibronectin and epidermal growth make new epihelial surface made up of fibroblasts, collagen and proeoglycan

Hint 4

epi, fibro/col/pro

Front 5

remodeling phase of wound healing

Back 5

size decreased by myofibroblasts
collagen collects to make scar

Hint 5

scar,size

Front 6

2 branches of immune system

Back 6

cell mediated imumunity
humoral immunity

Front 7

cell mediated immunity

Back 7

lymphocytes neutrophils T cells

Hint 7

l,n,t

Front 8

humoral immunity

Back 8

antibodies , made by b lymphocytes and generate immunoglobins

Front 9

cluster determinants

Back 9

CD - markers on the surface of t cells

Hint 9

t cells

Front 10

immunoglobins

Back 10

antibodies, made by b lymphoctytes, on prior exposure to an antigen

Front 11

types of immunoglobins

Back 11

IgA, IgD, IgE, IgG, IgM

Front 12

IgA

Back 12

in body secretions

Front 13

IgD

Back 13

very low levels in blood

Front 14

IgE

Back 14

bound to mast and basophils for allergic response

Hint 14

allergic

Front 15

IgG

Back 15

seen in later exposure

Front 16

IgM

Back 16

seen in initial exposure

Front 17

opsonization

Back 17

antibodies recognize and coast invading cell o all phagocytic cells to engulf it

Hint 17

coat

Front 18

DeGeorge syndrome

Back 18

t cell deficiency, defective embryological development of thymus and parathyroid, heart defects, facial, low calcium, death as infant

Hint 18

Tcell,low calcium

Front 19

selective IaA deficiency

Back 19

lose IgA found indigestive and respiratory tracts, more infections

Hint 19

found in body secretions

Front 20

bruton disease

Back 20

x linked hypogammaglobulinemia, maure B cells are absent

Hint 20

x link, B's

Front 21

wiscott aldrick syndrome

Back 21

rare, x linked, deficent T cll and B cell, basterial infections, low platelet, eczema, die as infant from infection and bleeding, need marrow transplant

Hint 21

T & B,

Front 22

adensosine deaminase ADA deficiency

Back 22

autosomal recessive, immune deficiency, nucleotide, overwhelming inection and death, use gene therapy

Hint 22

nucleotide

Front 23

severe combined immunodeficiency SCID

Back 23

defective lysosomal granules, they are needed to destroy invading organisms

Hint 23

lyso

Front 24

AIDS/HIV

Back 24

retrovirus, a RNA virus that encodes reverse transcriptase to convert to DNA, kills CD4 cells

Front 25

Autoimmune diseases

Back 25

graves
hasimotos thyroditis
sjogren sndrome
SLE,lupus
scleroderma

Hint 25

thyroid,dry,butterfly,hide

Front 26

hasimoos thyroditis

Back 26

HYPO

Front 27

sjogren syndrome

Back 27

dry eyes, dry mouth, epsein bar can trigger, salivary lacrimal glands are target, atrophy

Hint 27

dry

Front 28

SLE, lupus

Back 28

autoantibodies againist DNA, RNA, antibodies form immune complexes that block circulation and deposit in tissue causing inflammatory response, rash photosensiivity, glomerulonephritis, joints, anemia, low WBC, low platelets, brain(seizure)
common: Arthritis,Rash, Kidney

Hint 28

inflammatory reponse, A,R,K

Front 29

scleroderma

Back 29

connective tissue is the target, thickened skin, loss of facial expression,loss movement/joint,hide bound

Hint 29

connective tissue

Front 30

limited scleroderma/creast

Back 30

raynauds (color change fingers),esophageal (swallowing), sclerodactly (tight skin fingers)

Hint 30

raynauds

Front 31

hypersensitivity reactions I

Back 31

hives, hay fever, rapid,local

Front 32

hypersensitivity reactions II

Back 32

IgM, IgG, macrophages, ABO incompatible

Hint 32

blood trans

Front 33

hypersensitivity reactions III

Back 33

antibodies form complexes, serum sickness, lupus, glomerulonephritis,

Hint 33

lupus

Front 34

hypersensitivity reactions IV

Back 34

delayed, no antibdoes, antigens are processed by macrophages 24-48 hrs, contact dermatitis, poison ivy, TB test

Hint 34

no antibodies, delay

Front 35

transplant

Back 35

HLA (human leukocyte antigens) recognition of foreign proteins that lead to rejectins - T cells are activated by the foreign MHC on the molecules of the graft

Front 36

transplant rejections
hyper,acute,chronic

Back 36

hyper - within mins, swell/bleed remove it
acute - within weeks, pain, swell give more immune meds
chronic - months, slow insidious failure, difficult to save