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12 Cards in this Set
- Front
- Back
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What are secondary immune compromised states?
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Those caused by illness or a normal physiologic state like aging or pregnancy.
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How do primary immune deficiencies present?
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Unusual or recurrent, severe infections
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How do B cell deficiencies present?
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Microorganisms sensitive to antibodies- encapsulated bacteria (Strep pheumoniae, H. influenzae, sinus/ear/GI infections)
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What are examples of B cell deficiencies?
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Bruton gammaglobulinemia, autosomal agammaglobulinemia, X-linked hyper-IgM syndrome, IgG subclass deficiency, common variable immune deficiency
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How do T cell deficiencies present?
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Fungal, viral, intracellular bacterial infections
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What are examples of T cell deficiencies?
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DiGeorge Syndrome, chronic mucotaneous candidiasis
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What are s/s of combined T and B cell deficiencies?
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No tonsils, thymus, no T/B/phagocytes- frequently incompatible with life
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What are examples of combined T/B deficiencies?
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Reticular disgenisis (most severe), ADA deficiency, X-linked SCID (most common), bare lymphocyte syndrome, Wiscott-Aldrich Syndrome (no IgM, get TCP), ataxia-telangiectasia (no IgA)
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How do complement deficiencies present?
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Recurrent disseminated Nisseria infections, esp gonorrhea and meningitis
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What are examples of complement deficiencies?
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C3 (most severe), MBL deficiency (polysaccharide capsule vulnerability), C9 deficiency (Japanese, asymptomatic)
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What are examples of phagocytic deficiencies?
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Severe congenital neutropenias (cyclic neutropenia- milder), leukocyte adhesion deficiency, C3 receptor deficiency (bac skin infections), Chediak-Higashi (G+ skin inf)
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What are treatments for immune deficiencies?
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Gamma-globulin therapy, transplantation, transfusion, soluble immune mediators, gene therapy
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