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8 Cards in this Set
- Front
- Back
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What are histocompatibility antigens?
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These are important for the recognition of foriegn antigens by T lymphocytes.
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Give an example of the above.
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CD8 cytotoxic T lymphocytes can recognize a foriegn antigen only if that antigen is complexed to self class 1 antigens.
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Do these class 1 molecules bind to proteins synthesized within the cell?
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Yes. An example is the cellular production of viral antigens. The CD8 molecule of the cytotoxic T cell binds to the non polymorphic portion of the class 1 molecule, while the T cell receptor on the surface of the T lymphocyte binds to a complex formed by the peptide fragment of the antigen and the class 1 antigen.
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What do CD4 helper T lymphocytes recognize?
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They can recognize a foriegn antigen only if that antigen is complexed to self class 2 antigens.
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Class 11 antigens present foriegn antigens that have been processed within the cell in endosomes or lysosomes, one example is bacteria. True/False
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True.
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Macrophages and neutrophils are active phagocytes and have receptors for the Fc portion of IgG and C3b. True/False
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True.Both of these substances are important opsonins.
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Do macrophages present antigens to T cells?
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Yes. They ingest and present antigens to T cells in conjunction with surface class 11 antigens.
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What about class 111 antigens.
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These antigens are not involved in histocompatibility, but include proteins of the complement cascade.
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