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11 Cards in this Set
- Front
- Back
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What are paraneoplastic syndromes?
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Symptoms not caused by either local or metastaic effects of tumors.
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Bronchogenic carcinomas are associated with the development of many different types of paraneoplastic syndromes. TRUE/FALSE
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TRUE.
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What are these syndromes usually associated with?
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The secretion of certain substances by the tumor cells. Ectopic secretion of ACTH may produce Cushing's syndrome, while ectopic secretion of ADH(inappropriate ADH secretion) may produce hyponatremia.
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HYpocalcemia can result from what?
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From the production of calcitonin, while hypercalcemia can result from the production of parathyroid hormone related peptide(PTHrP).
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What is PTHrP?
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It is a normal substance produced locally by many different types of tissues. It is distinct from PTH.
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Regarding PTHrP, patients with this type of paraneoplastic syndrome have increased Ca+ levels and decreased PTH levels. TRUE/FALSE
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TRUE. As a result of decreased PTH production, patients have atrphied parathyroid glands.
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What other tumors are associated with the production of PTHrP?
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Clear cell carcinomas of the kidney, endometrial carcinoma and transitional carcinomas of the urinary bladder.
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Are lung cancers associated with multiple migratory venous thromboses?
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Yes.THis migratory thrombitis is called Trousseau's sign and is more classically associated with carcinoma of the pancreas.
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What is hypertrophic osteoarthropathy?
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It is a syndrome consisting of periosteal new bone formation with or without digital clubbing and joint effusion.
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What is hypertrophic osteoarthropathy often associated with?
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With lung carcinomas, but it also occurs with other types of pulmonary disease.
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What is erythrocytosis often associated with?
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With increased erythropoietin levels and some tumors, particularly renal cell carcinoma, hepatocellular carcinomas, cerebellar hemangioblastomas. It is not really associated with bronchogenic carcinomas.
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