Pathophys Gi Charts Gi Manifestations Of Systemic Diseases

Front 1

patient comes in with low gastric acid and megaloblastic anemia

Back 1

Autoimmune thyroiditis
- Achlorhydria
-pernicious anemia
-Autoimmune destruction of parietal cells

Front 2

patient comes in with constipation, malabsorption, and pain in chest after eating and laying down.

Back 2

Hypothyroidism
- esophageal reflux (lower esophageal sphincter dysfunction)
- constipation (intestinal dysmotility)
- gastric dysmotility
- malabsorption (villous atrophy, pancreatic insufficiency)
- bezoars (gastric dysmotility)

Front 3

patient comes in with diarrhea and weight loss. what hormonal problem could cause this?

Back 3

hyperthyroidism
- intestinal hypermotility w/ rapid transit and malabsorption

Front 4

abdominal pain, diarrhea, malabsorption w/ atrophic brush border. what hormonal problem could cause this?

Back 4

adrenal insufficiency
- malabsorption from loss of trophic effect of corticosteroids on enterocyte brush border

Front 5

hypercalcemia, nausea, vomiting, acid peptic disease

Back 5

Primary hyperparathyroidism
- hypercalcemia induced changes in signal transduction. causes dysmotility and gastric atony
- hypercalcemia induced premature activation of pancreatic enzymes --> PANCREATITIS
- hypercalcemia induced increased acid secretion (acid-peptic disease)

Front 6

GI complications of Diabetes Mellitus?

Back 6

- esophageal, gastric, small and large intestinal and rectal dysfunction (like entire GI) via autonomic neuropathy
- nausea, vomit, abdominal pain (keotoacidosis w/ gastric atony)

Front 7

GI complications of pregnancy?

Back 7

pressure effect of uterus on lower esophageal sphincter (reflux), gastric emptying (nausea, vomitting), intestinal transit time (constipation), venous return (hemorrhoids)
- esophageal reflux
- nausea, vomit
- hematemesis
- constipation
-hemorrhoids

Front 8

GI complications of zinc or niacin deficiency?

Back 8

Malabsorption syndrome via altered enterocyte brush border

Front 9

GI complications associated with cancer?

Back 9

- Pain, fever, bleeding, ascitis, obstruction, perforation (metastases, often breast cancer, melanoma, bronchogenic carcinoma of lung)
- paraneoplastic syndromes and hypercalcemia (tumor produced peptides)

Front 10

Gi complications associated with hematologic conditions (bleeding disorders, hypercoagulable states, dysproteinemias)

Back 10

-intramural hematoma (bleeding)/hemorrhage
- bowel infarction/intestinal ischemia (hypercoagulable)
- hemorrhage, obstruction, amyloidosis via infiltration in dysproteinemias

Front 11

GI complications of Rheumatologic disorders (Scleroderma, SLE, Rheumatoid Arthritis)?

Back 11

- inflammation, vasculities, vascular obliteration, villous atrophy (dysphagea, esophageal reflux, obstruction, bleeding, perforation, pseudo-obstruction, pancreatitis, malabsorption)
-nausea, vomit, mucosal ulcers
- GI ulcers, gastritis (aspirin or NSAID use for condition)

Front 12

GI complications of Metabolic and infiltrative disorders (dyslipidemias, sarcoidosis, amyloidosis)

Back 12

- infiltration, muscle atrophy, dysmotility (malabsorption)
- infiltration, mucosal ischemia, infarction

Front 13

GI complicatiosn of renal disorders (like chronic renal failure, transplants)

Back 13

gastritis, duodenitis, pancreatitis
- abdominal pain, GI bleeding, intestinal perforation

Front 14

GI complications of neurlogic disorders (spinal cord injur, myotonic dystrophy, CNS disease)

Back 14

- disordered central and enteric nervous system communication causing impaired gut motility
- nausea, vomit, chronic constipation

Front 15

GI complications of pulmonary disorders (asthma, cystic fibrosis)

Back 15

- nocturnal aspiration causing esophageal reflux
- pancreatic exocrine insufficiency in cystic fibrosis (diarrhea, malabs. weight loss)