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6 Cards in this Set
- Front
- Back
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Where do clinical manifestations of disease come from
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Directly from the microorganism, its products, or from host response.
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What are typical initial symptoms of infection
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Fatigue, malaise, weakness, decreased concentration, aching, decreased appetite, fever
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How does fever happen
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Pyrogens cause the hypothalamus to reset its "thermostat" higher.
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What are some endogenous pyrogens
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IL-1, IL-6, interferon, tumor necrosis factor, other cytokines
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How do pyrogens work
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They stimulate prostaglandin synthesis in the brain and peripheral tissues
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What is tumor necrosis factor
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Cachectin. A cytokine produced by macrophages in response to endotoxin exposure. Promotes chachexia in cancer patients
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