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23 Cards in this Set
- Front
- Back
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SLE affects more men or women?
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women 9x - especially African American, Hispanic, Asian
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what is the pathology of SLE?
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production of ANA antinuclear antibodies
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It is believed that the hyperactivity of B cells associated with SLE is due to either _________ or _________
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xs/hyperactive helper-T cells
defective T-suppressor cells |
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List the correct order of events that occurs in SLE
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hyperactive Bcells-> increase production of auto Ab antibodies
+Ag -> immune complex (IC) -> ICs deposits on tissues ->inflammatory response ->local tissue injury |
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Your px exhibits arthritis and blurry vision, and has a red rash on her face, all of which seem to come and go periodically. and she complains that she is losing her hair
what is your diagnosis...and what are some manifestations that may occur if condition is not controlled? |
SLE
pitted nails, sun senitivity pericarditis, pleural effusion nephritis, glomerulonephritis vasculitis -> stroke, seizure, retinopathy hemolytic anemia, leukopenia, thrombocytopenia |
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what is the purpose of SLE Tx?
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maintain organ function
reduce exacerbation minimize disability |
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Ankylosing Spondylitis seems to be very closely linked to which gene?
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HLAb27
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which of the following have strong genetic ties?
a) Reactive Arthritis b)SLE c)Ankylosing Spondylitis d)All e) a&B |
RA - HLA-DR4
Ankylosing Spondylitis - HLA-B27 |
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Ensethopy is ____________ and it is the pathology of _______
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Ankylosing Spondylitis=
inflammation at the site of attachment of tendon, ligament to bone- -causing fibrosis, calcification, and ossification of joints of the tendons |
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which are of the body does Ankylosing spondylitis primarily affect?
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axial skeleton starting with the lumbo-sacral area
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what is enthesopathy and what is this the pathology of?
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inflammation at the site of attachment of tendon/ligament/bone - it causes fibrosis/ossification of the joints/tendons - causing anklyosis/stiffness
ankylosing spondylitits |
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what are the primary manifestations of Ankylosing Spondylitis?
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later/gradual onset
chronic sacral back pain w prolonged morning stiffness better with exercise and worse w rest->loss of mvt Kyphosis uveitis exacerbation/remission periods |
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what are the major diagnostics for ankylosing spondylitis?
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HLA B27 in blood
Bamboo Spine - xray family history |
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Your patient has arthritis especially in the lower extremities, and it is worse when his bowels are more reactive due to ulcerative colitis condition.
what is your diagnosis? |
Reactive Arthritis/enteropathic arthropathies
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T/F
Psoriatic arthritis is generally RF +/- ? |
RF (-)
25% RF+ and exhibit symmetrical polyarthritis |
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Your px has psoriasis, how will arthritis likely manifest upon flare ups?
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DIP Arthritis
Asymmetrical Oligoathritis Sacroiliitis Symmetric polyarthritis if RF+ |
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what causes osteoarthritis?
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repeated trauma
aging-decreased proteoglycan, loosening cartilage collagen gene defect inflammation-immune complex obesity neuropathy deposition of gout diabetes recurrent subluxation/osteomyleitis |
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describe the process of a joint injury that can later lead to osteoarthritis
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repetitive joint injury->
damages cartilage/chondrocytes-> release of protease and collagenase-> cracking/fibrillation of cartilage-> cartilage repair/recovery if no more stress |
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Describe the process of osteoarthritis if joint repair is overwhelmed by additional injuries
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1) deeper crack into subchondral bone
causing a cyst->bone rxn->osteophyte 2) loss of proteoglycan->dry/stiff cartilage->abnormal force to bones and/or rough motion of the joint/narrowing of the joint cavity |
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what is an osteophyte and when are they likely to appear?
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bone spur that developes in order to increase SA to decrease stess on the bone
occurs in osteoarthritis- and aggravates the surrounding tendons and ligaments |
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your px has morning stiffness and limited range of motion in his shoulders. upon examination you find that the synovial fluid is turbid.
what is the likely diagnosis |
osteoarthritis
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what are some diagnostic signs of Osteoarthritis
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turbid synovial fluid
xray -narrowing joints pace -subchondral sclerosis -osteophyte |
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list 4 treatments for osteoarthritis
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weightloss
joint rest support exercise heat/cold drugs |
