Pathophys 1 Alterations In Immune Response

Front 1

Cell mediated immunodeficiency disease

a) Atopic Disorder
b) Non-Atopic Disorder
c) HIV
d) Secondary disorder of phagocytosis

Back 1

secondary disorder of phagocytosis

Front 2

T/F

You are born with secondary disorder of phagocytosis

Back 2

F- acquired later in life

Front 3

list the causes of secondary disorder of phagocytosis

Back 3

corticosteroids
cyclosporin A
diabetes mellitus

Front 4

List the types of IgE related allergies

Back 4

Atopic
non atopic- no genetic component, no organ specificity

Front 5

List the types of allergies

Back 5

Type IIgE mediated
Type II antibody mediated (cytotoxic)
Type III immune complex
Type IV cell mediated

Front 6

which of the following allergies does not react immediately

a) Type IV cell mediated
b) Type II Antibody Mediated
c) Type I IgE mediated
d) all are immediate

Back 6

Type IV cell mediated

(type III immune complex can be immediate or delayed)

Front 7

What triggers an IgE mediated allergic response

Back 7

binding of allergen to specific IgE on mast cell or basophil -> release allergy producing mediators

Front 8

List allergy producing mediators

Back 8

histamine ***
complement
acetycholine
leukotriene
prostaglandin
kinin
chemotactic factors

Front 9

which does not cause bronchoconstriction

a) histamine
b) kinine
c) acetylcholine
d) all cause constriction

Back 9

kinin

Front 10

histamine causes

a) vasodilation
b) vasoconstriction
c) bronchoconstriction
d) pain

Back 10

vasodilation
bronchoconstriction

Front 11

which disorder is likely to be hereditary

a) atopic disorder
b) non atopic disorder
c) Arthus reaction
d) all

Back 11

atopic - hereditary IgE mediated allergy -> produce local response

Front 12

list the manifestations of an Atopic Disorder

Back 12

allergic rhinitis
asthma
atopic dermatitis

Front 13

Treatments for Atopic Disorders include all except

a) antihistamine
b) steroid
c) desensitization
d) all

Back 13

all

Front 14

T/F

non-atopic disorders are organ specific

Back 14

F

Front 15

which is not an example of a non-atopic response

a) anaphylaxis
b) arthus reaction
c) poison oak
d) hives

Back 15

arthus reaction = immune complex
poison oak = cell mediated

(non atopic = anaphylaxis, uticaria, hives)

Front 16

A baby being born with jaundice due to erythroblastosis fetalis is an example of

a) Non-atopic disorder
b) Type II- antibody mediated response
c) Autoimmunity
c) Graft vs Hose rejection

Back 16

Type II- antibody mediated allergic response

also - mismatch blood transfusion

Front 17

the deposition of Ag-Ab complex on tissues triggers Type II antibody mediated allergic response

Back 17

F

Ag-Ab deposition cause immune complex response -> activation of complement system-> local or systemic reaction

Type II trigger = IgM and IgG binding to Ag -> immune response

Front 18

what is the trigger for Type IV cell mediated allergic response

Back 18

CD4 binding to antigen -> release cytokines

Front 19

Type III immune complex reaction

a) Foods
b) arthus reaction
c) TB
d) all

Back 19

foods
arthus reaction

also, serum sickness, penicilin, venom, insect bites

Front 20

list examples of type IV cell mediated allergic response

Back 20

TB test
contact dermatitis
poison oak

Front 21

which type of allergic reaction will have a delayed response to exposure and can last for weeks?

Back 21

type iv cell mediated

Front 22

list the types of transplant donors

Back 22

allogenic (related or non-related)
syngenic - identical twin
autologus- donate to self

Front 23

Host vs Graft rejection occurs mostly in ___ transplants

Back 23

allogenic

Front 24

Which is not true about a Host Vs Graft rejection

a) Host has a compromised immune system
b) Humoral Mechanism
c) Immune cells of recipient attack donor
d) Cell Mediated Mechanism

Back 24

host has compromised immune system (graft vs host rejection)

Front 25

Host vs Graft Rejection is

a) hyperacute
b) acute
c) chronic
d) all

Back 25

all

Front 26

A patient with leukemia needs a bone marrow transplant. What is the risk of this procedure

a) Host vs Graft rejection
b) Cell Mediated Allergic reaction
c) Graft vs Host rejection
d) Immune Complex Allergic reaction

Back 26

Graft Vs Host rejection

Front 27

What are the agents in GVHD?

a) Tcell of recipient
b) HLA of recipient
c) Tcell of donor
d) HLA of donor

Back 27

Tcell of donor
HLA of recipient (MHC complex)

Front 28

list the requirements of GVHD

Back 28

-transplant must have a functional cellular immune competent
-recipient must have Ag foreign to donor
-recipient immunity must be compromised enough so that it cannot destroy transplant cells

Front 29

T/F

autoimmune disorders can affect any cell or tissue in the body

Back 29

true

Front 30

with an autoimmune disorder there is a dysfunction of which potential mechanisms

Back 30

-peripheral mech- suppresses self reactive Tcells
-Clonal Anergy- non reactive Tcells to self antigens/cells that do not express MHCII molecule
-Clonal Deletion- elim self reactive T/B lymphocytes

Front 31

Which is related to self tolerence

a) HLA- DR4
b) Super Ag
c) Clonal Deletion
d) Trigger factor

Back 31

clonal deletion

HLA-DR4- genetic predisposition (RA)
Super Ag- mechanism for autoimmunity

Front 32

T/F

All persons with a genetic predisposition for an Autoimmune Disease will develop autoimmunity later in life

Back 32

F

trigger factor may induce autoimmunity but not necessarily

Front 33

list the mechanism for autoimmunity

Back 33

aberration/abnormal of Ag
disorder of immune regulatory function
aberration/abnormal T cell receptors
super Ag

Front 34

____ used to treat Auto-immunity

Back 34

corticosteroids- control symptms and suppress immune system

Front 35

What kinds of tests are used to diagnose autoimmunity

a) Elisa test
b) Serologic test
c) Western Blot
d) none

Back 35

serologic test- look for Ab against certain Ag/Tissue