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23 Cards in this Set
- Front
- Back
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Rb gene
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tumor suppressor gene on chromosome 13q
associated tumor: retinoblastoma, osteosarcoma |
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BRCA1
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tumor suppressor gene on chromosome 17q
associated tumor: breast and ovarian cancer |
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BRCA2
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tumor supressor gene on chromosome 13q
associated tumor: breast cancer |
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p53
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tumor suppressor gene on chromosome 17p
associated with: most human cancers, li-fraumeni syndrome |
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p16
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tumor suppressor gene on chromsome 9p
associated tumor: melanoma (melaNoma is on Nine) |
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APC
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tumor suppressor gene on chromsome 5q
associated tumor: colorectal cancer (FAP) |
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WT1
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tumor suppressor gene on chromosome 11p
associated tumor: whilms' tumor |
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NF1
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tumor suppressor gene on chromosome 17q
associated tumor: NF type 1 |
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NF2
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tumor suppressor gene on chromosome 22q
associated tumor: NF type 2 (type 2 = 22) |
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DPC
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tumor suppressor gene on chromosome 18q
associated tumor: pancreatic cancer (DPC - deleted in pancreatic cancer) |
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DCC
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tumor suppressor gene on chromosome 18q
associated tumor: colon cancer (DCC - Deleted in colon cancer) |
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PSA is a marker for what cancer?
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Prostate specific antigen. Used to screen for prostate carcinoma. Can be elevated in BPH and prostatitis
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Prostatic acid phosphatase is what?
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a maker for prostate carcinoma
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CEA
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Carcinoembryonic antigen. very nonspecific but produced by ~70% colorectal and pancreatic cancers; also produced by gastric and breast carcinomas
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a-fetoprotein
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normally made by the fetus. hepatocellular carcinomas
nonseminomatous germ cell tumors of the testis (yolk sac tumor) |
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B-hCG
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Hydatidiform moles, Choriocarcinoma, and Gestational trophoblastic tumors
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CA-125
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tumor maker for ovarial cancer and malignant epithelial tumors
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S-100
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tumor marker for melanoma, neural tumors, astrocytomas
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Alkaline phosphatase
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mets to the bone, obstructive biliary disease, paget's disease of bone
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Bombesin
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tumor maker for neuroblastoma, lung and gastric cancer
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TRAP
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Tartrate-resistant acid phosphatase. tumor marker for hairy cell leukemia (B-cell neoplasm)
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Ca-19-9
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tumor marker for pancreatic adenocarcnioma
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What should tumor makers be used for and what should they not be used for?
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should not be used at the primary diagnositic tool for cancer diagnosis. Can be used to confirm a diagnosis to monitor tumor recurrence, and to monitor response to therapy
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