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23 Cards in this Set

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Rb gene
tumor suppressor gene on chromosome 13q
associated tumor: retinoblastoma, osteosarcoma
BRCA1
tumor suppressor gene on chromosome 17q
associated tumor: breast and ovarian cancer
BRCA2
tumor supressor gene on chromosome 13q
associated tumor: breast cancer
p53
tumor suppressor gene on chromosome 17p
associated with: most human cancers, li-fraumeni syndrome
p16
tumor suppressor gene on chromsome 9p
associated tumor: melanoma (melaNoma is on Nine)
APC
tumor suppressor gene on chromsome 5q
associated tumor: colorectal cancer (FAP)
WT1
tumor suppressor gene on chromosome 11p
associated tumor: whilms' tumor
NF1
tumor suppressor gene on chromosome 17q
associated tumor: NF type 1
NF2
tumor suppressor gene on chromosome 22q
associated tumor: NF type 2 (type 2 = 22)
DPC
tumor suppressor gene on chromosome 18q
associated tumor: pancreatic cancer (DPC - deleted in pancreatic cancer)
DCC
tumor suppressor gene on chromosome 18q
associated tumor: colon cancer (DCC - Deleted in colon cancer)
PSA is a marker for what cancer?
Prostate specific antigen. Used to screen for prostate carcinoma. Can be elevated in BPH and prostatitis
Prostatic acid phosphatase is what?
a maker for prostate carcinoma
CEA
Carcinoembryonic antigen. very nonspecific but produced by ~70% colorectal and pancreatic cancers; also produced by gastric and breast carcinomas
a-fetoprotein
normally made by the fetus. hepatocellular carcinomas
nonseminomatous germ cell tumors of the testis (yolk sac tumor)
B-hCG
Hydatidiform moles, Choriocarcinoma, and Gestational trophoblastic tumors
CA-125
tumor maker for ovarial cancer and malignant epithelial tumors
S-100
tumor marker for melanoma, neural tumors, astrocytomas
Alkaline phosphatase
mets to the bone, obstructive biliary disease, paget's disease of bone
Bombesin
tumor maker for neuroblastoma, lung and gastric cancer
TRAP
Tartrate-resistant acid phosphatase. tumor marker for hairy cell leukemia (B-cell neoplasm)
Ca-19-9
tumor marker for pancreatic adenocarcnioma
What should tumor makers be used for and what should they not be used for?
should not be used at the primary diagnositic tool for cancer diagnosis. Can be used to confirm a diagnosis to monitor tumor recurrence, and to monitor response to therapy