Pathology: Tbl 2 Neoplasia

Front 1

This paraneoplastic syndrome causes ACH to be secreted and may lead to excessive retention of water by the kidney's.

Back 1

SIDAH

Front 2

In patients with solid tumors who do not have metastasis, hypercalcemia is most often caused by:

Back 2

PTHrP (Parathyroid hormone related polypeptide)

Front 3

PTHrP is most often caused by which cancer:

Back 3

Squamous cell carcinoma of the lungs.

Front 4

Name the three effects of PTH:

Back 4

1.Retention/mobilization of calcium
2.Excretion of phosphorus
3. hydroxylation of vitamin D in the kidney

Front 5

This increases the absorption of calcium in the gut, promotes reabsorption in the kidneys, and promotes PTH reabsorption of bone:

Back 5

Activated Vitamin D

Front 6

Vitamin D related hypercalcemia, due to vitamin D inoxication can be caused by several granulomatous diseases such as:

Back 6

Sarcoidosis, Tuberculosis, or fungal infections.

Front 7

Name for condition with increased number of red blood cells:

Back 7

Polycythemia

Front 8

Condition associated with hepatocellular and renal cellular carcinomas as well as cerebellar hemangiomas

Back 8

Polycythemia

Front 9

50% of patients with Cushing's Syndrome have what?

Back 9

Lung cell carcinoma

Front 10

This condition is caused by excess ACTH

Back 10

Cushing's Syndrome

Front 11

Hypercalcemia is common in breast carcinoma patients who have _____

Back 11

Bone Metastasis

Front 12

This condition is readily seen on radiographs and often seen with pathologic fractures- what kind of cancer is it associated with?

Back 12

Osteolytic Metastases

Front 13

A mutation in this gene is associated with retinoblastoma, osteogenic sarcoma, and breast carcinoma:

Back 13

Rb

Front 14

This cell cycle and apoptotic regulator inhibits G1 to S phase, repairs DNA and activates BAX

Back 14

p53

Front 15

In cells with a deficiency of this tumor supressor gene DNA damage doesn't lead to cell cycle arrest, which may lead to lung, colon, breast carcinomas, LF syndrome, brain tumors, leukemia, and sarcoma:

Back 15

p53

Front 16

Loss of this tumor supressor gene is associated with familial polyposis (colorectal carcinoma)

Back 16

APC

Front 17

When this signal transduction inhibitor is lost or inactive, destruction of beta-catenin cannot occur, which leads to entry into the cell cycle:

Back 17

APC

Front 18

Malfunction of these DNA repair genes is associated with breast, ovary, and prostate carcinomas.

Back 18

BRCA1 and 2

Front 19

This paraneoplastic syndrome is associated with an increase in cortisol:

Back 19

Cushing's Syndrome

Front 20

These two paraneoplastic syndromes are associated with small cell lung cancer:

Back 20

Cushing's and SIADH

Front 21

This paraneoplastic syndrome is associated with increased EPO. What are the two associated cancers?

Back 21

Polycythemia- renal cell and hepatocellular carcinoma

Front 22

This paraneoplastic syndrome is associated with breast, lung, kidney ovary, and squamous cell carcinoma of the lung

Back 22

Hypercalcemia

Front 23

This gene is associated with multiple endocrine neoplasia 1 and 2

Back 23

MEN1 and RET

Front 24

These genes are associated with inherited risk for breast and ovarian cancers

Back 24

BRCA 1 and 2

Front 25

These genes are associated with neurofibromitosis 1 and 2

Back 25

NF1 and NF2