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11 Cards in this Set
- Front
- Back
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What does the following describe:
-CT disorder -inflammation of skeletal muscle and skin that affects children and adults -bilateral proximal muscle weakness -skin rash of the upper eyelids -periorbital edema -pts have inc risk of lung, stomach, and ovarian cancers (visceral malignancies) |
Dermatomyositis
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What is the autoimmune disease the involving the loss of nicotinic receptors at the neuromuscular junction on the post-synaptic membrane?
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Myasthenia Gravis
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What does the following describe:
-muscular weakness (mostly facial muscles) -Ptosis and Diplopia -weakness worsens with repeated contractions -death d/t resp muscle involvement -**associated with Thymic hyperplasia and thymomas** |
Myasthenia Gravis
Dx with Edrophonium Tx with Acetylchoinesterase inhibitors |
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Eaton-lambert syndrome
-key features |
-paraneoplastic syndrome of small cell lung cancer
-proximal muscle weakness -IMPROVES with repeated contractions -Ab against Ca++ Channels of neuromuscular junction |
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What does the following describe:
-X-linked form of muscular dystrophy -dystrophin gene on X chromosome --> absence of dystrophin protein -causes rapid progression of muscular degeneration -Affects males -usually have symptoms by 5 yo (normal at birth) -calf pseudohypertrophy -proximal weakness of shoulder and pelvic girdles -Labs = inc Serum Creatine Kinase |
Duchenne muscular dystrophy
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Guillain-Barre Syndrome
-key elements |
-autoimmune disease
-destruction of Schwann cells and peripheral nerve demyelination -preceded by a viral illness -ascending paralysis -loss of DTRs |
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Lipoma
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-benign adipose tissue tumor
-most common benign soft tissue tumor -arises in subQ tissue of trunk, neck, or proximal extremities -cosmetic more than medical |
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Liposarcoma
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-Deeper = Malignant adipose tissue tumor
-most common adult sarcoma -usually thigh, retroperitoneum -contains lipoblasts (lipomas do not) |
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Fibrosarcoma
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-malignant fibrous tumor
-usually thigh, upper limb -arise spontaneously or after irradiation -herringbone pattern -hypoglycemia |
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Malignant fibrous histiocytoma
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-malignant tumor that has pleomorphic cells
-usually retroperitoneum, thigh -arise after radiation therapy and scarring |
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Embryonal Rhabdomyosarcoma
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-most common sarcoma of children
-from striated muscle -grape-like, necrotic mass -protrudes from penis or vagina |
