Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
32 Cards in this Set
- Front
- Back
|
resolution
|
injury causing minimal tissue destruction; no residual evidence of injury is noted
|
|
|
best example of resolution
|
lobar pneumonia
|
|
|
crisis
|
form of resolution where suddenly the patient gets well and it all resolves at the same time
|
|
|
resolution by lysis
|
after severe respiratory infection; feel a little better everyday; not sudden
|
|
|
repari
|
injury caused substantial tissue destruction
|
|
|
regeneration
|
replacement of the injured tissue by cells of the same type; orderly proliferation
|
|
|
what does regeneration require
|
cell proliferation
|
|
|
labile
|
cells that have an unlimited capacity to divide; skin and GI
|
|
|
stable
|
cells that can undergo rapid division under the right stimuli and thus capable of reconstituting the tisse of origin
|
|
|
permanent
|
cells that have left the cell cycle and cannot undergo mitotic division in postnatal life
|
|
|
stem cells
|
prolonged self renewal capacity and by their asmmetric replication
|
|
|
types of stem cells
|
embryonic and adult; adult has restrictive capacity except in the bone marrow
|
|
|
niches
|
location of stem cells
|
|
|
oval cells
|
bipotential progenitor cells capable of differentiating into hepatocytes and biliary cells
|
|
|
what controls cell growth
|
contact inhibition and growth factors
|
|
|
competence factors
|
growth factors that are unable to induce DNA synthesis
|
|
|
progression factors
|
growth factors that are able to induce DNA synthesis in competent cells
|
|
|
molecular events in cell growth
|
1. binding of ligand
2. activation of growth factor receptor 3. signal transduction and second messangers 4. transcription factors 5. cyclins |
|
|
functions of IL-1 and TNF
|
fibrogenic, induce fibroblast proliferation, chemotactic for fibroblasts, stimulate synthesis of collagen and collangenase
|
|
|
transcription factors
|
induce growth regulatory genes
|
|
|
epidermal growth factor
|
mitogenic for epithelial cells, fibroblasts and hepatocytes
|
|
|
platelet derived growth factor
|
competent factor; induces proliferation in fibroblasts, smooth muscle and monocytes
|
|
|
fibroblast growth factor
|
affinity for heparin and anionic molecules; induces angiogeneis; produced by macrophages
|
|
|
what makes up the ECM
|
structural proteins and adhesive glycoproteins embedded in a gel of proteoglycans and GAGs
|
|
|
when does collagen synthesis begin after an injury?
|
3-5 days into wound healing
|
|
|
What are involved in collagen degradation?
|
metalloproteinases; collageneases and gelatinases which remodels wounds
|
|
|
fibronectin
|
produced by fibroblasts, monocytes and endothelial cells; binds to ECM components via specific domains and to cells via integrin receptors
|
|
|
integrins
|
transmembrance glycoproteins anchoring to elements of the cytoskeleton
|
|
|
laminin
|
most abundant glycoprotein in BM; binds to cellular membrane receptors and to matrix components
|
|
|
most abundant GAG in ECM
|
hyaluronic acids
|
|
|
sequence of events for repair by connective tissue
|
1. angiogenesis
2. migration and proliferation of fibroblasts 3. deposition of ECM 4. remodeling of scar |
|
|
factors influencing wound healing
|
nutrition, glucocorticoids, infection, foreign bodies, venous drainage and blood supply, wound dehiscence
|
