Pathology Of Skin Diseases

Front 1

dark black papules that are usually multiple located on the head, neck, or trunk

Back 1

seborrheic keratosis

Front 2

associated with horn pseudocysts

Back 2

seborrheic keratosis

Front 3

sudden eruption of seborrheic keratosis (Leser-Trelat) is associated with what

Back 3

adenocarcinoma of GI tract

Front 4

pigmented plaques involving folds of the axilla and neck

Back 4

acanthosis nigricans

Front 5

what is associated with underlying malignancy (50% of the time) and more common in AA and hispanics

Back 5

acanthosis nigricans

Front 6

most common cutaneous cyst, has epidermis trapped in the dermis

Back 6

epithelial cyst

Front 7

erythematous keratotic lesions on sun damaged skin, no invasion

Back 7

actinic keratosis

Front 8

associated with keratinocyte atypia along the basal layer, but no invasion

Back 8

actinic keratosis

Front 9

squamous cell carcinoma-in-situ - 10-20% develop invasive SCC

Back 9

actinic keratosis

Front 10

quickly growing nodule with overlying scale or crusting

Back 10

squamous cell carcinoma

Front 11

associated with atypical epithelial cells invading the dermis with keratin pearl formation

Back 11

squamous cell carcinoma

Front 12

associated with UV radiation and capable of metastasis

Back 12

SCC

Front 13

pearly raised papules on sun exposed sites

Back 13

basal cell carcinoma

Front 14

nuclear palisading at edge of dermis, epidermis is unremarkable

Back 14

basal cell carcinoma

Front 15

most common cancer and malignant skin cancer

Back 15

basal cell carcinoma

Front 16

does BCC metastasize

Back 16

No - very rarely if does (0.1%)

Front 17

what type of skin cancer is more common in immunosupprssed patients

Back 17

SCC

Front 18

nodule confined to the dermis with dimple sign associated with young to middle aged adults

Back 18

benign fibrous histiocytoma

Front 19

yellow plaques associated with hyperlipidemias

Back 19

xathomas

Front 20

differentiate capillary vs. cavernous hemangioma

Back 20

capillary - juvenile, small vessels filled with red cells on head and neck
cavernous - liver, larger vessels filled with red cells

Front 21

should you treat a capillary hemangioma

Back 21

don't treat - will regress over time

Front 22

kaposi sarcomas associated with being located in distal lower extremities

Back 22

Ashkenazic jews in males older than 50
younger african males

Front 23

kaposi sarcoma associated with being located on the upper half of the body and causing disseminated disease

Back 23

AIDS-associated
immunosuppression from organ transplant

Front 24

spindle cell infiltrate with slit-like spaces containing red cells

Back 24

kaposi sarcoma

Front 25

sharply circumscribed plaques with silvery scale located on the scalp, groin, extensor surfaces

Back 25

psoriasis

Front 26

Munro's microabscesses

Back 26

neutrohils within the stratum corneum - psoriasis

Front 27

uniform elongation of rete ridges

Back 27

psoriasis

Front 28

chronic inflammatory dermatoses with HLA association

Back 28

psoriasis

Front 29

prominent pruritis with oral and genital most frequently involved

Back 29

lichen planus

Front 30

sawtoothing of rete ridges and band of lymphocytes in upper dermis (inflammatory disorder)

Back 30

lichen planus

Front 31

flaccid bullae in older individuals, oral mucosa involved 100%

Back 31

pemphigus vulgaris

Front 32

suprabasal acantholysis due to IgG against desmoglein 3

Back 32

pemphigus vulgaris

Front 33

tense blisters is elderly patient with subepidrmal blister

Back 33

bullous pemphigoid

Front 34

A blister associated with abundant eosinphils and no necrosis of overlying epidermis

Back 34

bullous pemphigoid

Front 35

two antigens associated with bullous pemphigoid, there is a linear IgG and C3 staining at dermal-epidermal junction

Back 35

BPAG1 and 2

Front 36

comedone

Back 36

dilated follicular infundibulum with keratinous plug creating an inflammatory response

Front 37

associated with HPV types 1, 2, 3, anf 4

Back 37

verruca vulgaris (warts)

Front 38

common in childhood with umbilicated with a central pore, eosinophilic cytoplasmic inclusion bodies

Back 38

molluscum contagiosum

Front 39

subcorneal (stratum corneum) postule filled with neutrophils caused by gram positive cocci

Back 39

impetigo

Front 40

where is melanin normally present

Back 40

skin and mucous membranes
eye (retina, choroid, iris)
brain (substancia nigra)
meninges

Front 41

someone lacking tyrosinase

Back 41

albino
Cannot form DOPA from tyrosine

Front 42

depigmentation, possibly autoimmune etiology

Back 42

vitiligo

Front 43

termed used to refer to any skin blemish

Back 43

nevus

Front 44

differentiate freckle and lentigo

Back 44

freckle - exposure to sun deepens the pigmentation, no junctional change
lentigo - pigmentation doesn't deepen with sun exposure, acanthosis (elongation of rete ridges - bottom of stratum spinosum)

Front 45

resemble melanocytes but lack dendritic processes

Back 45

nevus cells

Front 46

3 different types of nevus

Back 46

1. junctional (macule) - nevus cells at dermal/epidermal junction (basal layer of epidermis)
2. intradermal (papule or nodule) - nevus cells within the dermis
3. compound feature of both junctional and an intradermal lesion

Front 47

giant hairy nevus with a propensity to become melanoma

Back 47

congenital nevus

Front 48

benign mole in childhood that mimicks melanoma

Back 48

Spitz nevus

Front 49

dysplastic nevus syndrome

Back 49

inheritable cause of multiple dysplastic, benign nevi on covered potion of the body with underlying lymphocytic inflammation at the dermal/epidermal jxn

Front 50

nevus with irregular borders with recent change in sun-exposed region

Back 50

melanoma

Front 51

radial and vertical growth phases of melanoma

Back 51

radial - lateral spread
vertical - spread deep into dermis

Front 52

2 types of melanoma that invade epidermis only

Back 52

lentigo maligna melanoma
superficial spreading melanoma

Front 53

invasive melanoma with very little radial growth, poor prognosis because spreads into lymphatics

Back 53

nodular melanoma

Front 54

this melanoma already starts deep in tissues, associated with volar aspects of feet and hands

Back 54

acral lentiginous melanoma

Front 55

associated with S100 protein

Back 55

melanoma

Front 56

HMB-45

Back 56

monoclonal antibody that reacts with melanomas

Front 57

when does a melanoma have a poorer prognosis

Back 57

when invades into reticular dermis (Clark's level IV)

Front 58

Clark's levels

Back 58

I - in situ (no vertical growth)
II - invasion into papillary dermis
III - form a line at reticular dermis
IV - invade reticular dermis
V - invade subcutaneous fat

Front 59

melanoma less than or greater than 1.0 mm vertical invasion

Back 59

< 1.0 mm - good survival
> 1.0 mm - poor survival

Front 60

IgA antibodies form against gluten protein and form immune complexes which deposit in the dermal-epidermal junction and initiate inflammation

Back 60

dermatitis herpetiformis

Front 61

what is usually associated with dermatitis herpetiformis

Back 61

celiac disease

Front 62

hypersensitivity reaction associated with CD8 lymphocytes destroying basal cells at dermal-epidermal junction along with eosinophils

Back 62

erythema multiforme

Front 63

associated with forming a horn coming out from the skin

Back 63

actinic keratosis

Front 64

islands of tumor in the dermis associated with nuclear palisading

Back 64

basal cell carcinoma

Front 65

associated with being a sever form of erythema multiforme

Back 65

stevens johnson syndrome