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17 Cards in this Set
- Front
- Back
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what is absolutely necessary to make a diagnosis of lymphoma?
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a tissue sample
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what are the major B cell antigens?
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CD19, CD20, CD22
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what are the major T cell antigens?
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CD2, CD3, CD5, CD7
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flow cytometry of a patients lymophocytes show they express CD19, CD20, CD22, and CD45. what is the most likely diagnosis?
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Diffuse large B cell lymphoma
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a biopsy of a patient's lymph node is performed. Microscopically there are small cells with condensed chromatin and scant cytoplasm mixed with large cells with round nuclei and moderate cytoplasm (centroblasts). flow cytometry shows positive for CD19, CD20, CD22, CD10 and bcl2 and negative for CD5. what is the most likely diagnosis?
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follicle center lymphoma
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what is the chromosomal abnormality in follicle center lymphoma?
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t (14;18) translocation.
this places the bcl-2 gene next to the Ig heavy chain gene so bcl-2 gets over expressed |
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what is the prognosis for patients with follicle center lymphoma?
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poor. this usually presents at an advanced stage (III/IV) and is incurable
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what is the chromosomal abnormality in mantle cell lymphoma?
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t (11;14) translocation
causes cyclin D1 (bcl1) gene to be placed next to the Ig heavy chain gene causing over expression of cyclin D1 |
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flow cytometry of a patient's lymphocytes show they express CD19, CD20, CD22 and CD5. it also shows the cells are negative for CD10 and CD 23. what is the most likely diagnosis?
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mantle cell lymphoma
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what age group does mantle cell lymphoma affect?
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adults
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how can we distinguish between mantle cell lymphoma and B cell chronic lymphocytic leukemia?
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- mantle cell lymphoma is CD23 negative
- B cell CLL is CD23 positive |
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what is extranodular marginal zone lymphoma?
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a lymphoma that presents in extranodal sites usually the GI, salivary glands, thyroid, or skin
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a patient's lymphocytes are analyzed by flow cytometry and show CD19, CD20, CD22 positive and CD5 ,CD10 negative. they also show no rearrangement of bcl1 or bcl2. what is the most likely diagnosis?
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extranodal marginal zone lymphoma
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what age group does extranodal marginal zone lymphoma affect?
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adults
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flow cytometry of a patient's lymphocytes shows CD19, CD20, CD22 negatve, CD15, CD30 positive and CD45/LCA negative. what is the most likely diagnosis?
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nodular sclerosing hodgkin's disease
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what cell lineage does nodular sclerosing hodgkins disease derive from?
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it is unknown
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what is the prognosis for patients with nodular sclerosing hodgkins disease?
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good; this is highly curable even in late stages
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