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21 Cards in this Set
- Front
- Back
What disease is this?
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Goodpasture's syndrome
Linear (not granular) depositions of IgG |
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How would you describe the deposits on the glomerulus here?
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Granular
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What are clinically relevant places where type IV collagen found in the body/
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Lungs and glomeruli basement membrane
Goodpasture's |
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What are some immune complex diseases taht can cause glomerulonephritis?
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Post-infectious (strep)
Lupus IgA nephropathy/Henoch Schenlein Pupura |
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What is ANCA? What does it cause?
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Antibody against neutrophil cytoplasmic agents
It causes a pauci-immune GN |
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What diseases are in the differential diagnosis of a pulmonary renal syndrome?
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Goodpasture's disease
SLE ANCA positive small vessel vasculitis |
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What is the presentation of someone with Goodpasture's syndrome?
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Hemoptysis
RPGN |
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What don't you see in the microscropy of Goodpasture's disease?
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Electron dense deposits
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What is the treatment for Goodpasture's?
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Plasma exchange
Immunosuppression Rituximab: anti-CD20 Ab mediated B-cell depletion |
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What is the classic presentation of post-streptococcal GN?
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low C3!
RPGN around 21 days post-streptococcal infection |
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What is the treatment for post-streptococcal GN?
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Nothing.
It's self -limited--> supportive care only |
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What is the presentation of SLE nephritis?
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Systemic problems:
MSK aches Constitutional symptoms Rash Polyserositis Etc. RPGN Low C3 |
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What types of immunoglobulins and complement deposit in the kidneys of people with SLE?
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Ig: G, A, M
C: 1q, 4, 3 |
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What is the treatment of SLE?
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Primary:
Inti-inflammation: glucocorticoids Immunosuppression Secondary: ACEis/ARBs BP control |
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What is the clinical presentation of someone with IgA nephropathy?
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Slowly progressive
Limited to kidney Intermittent gross hematuria Edema |
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What are the serologic findings in IgA nephropathy?
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Normal C3
Ana, dsDNA, ANCA are all normal Everything looks normal! |
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What is the systemic variant of IgA nephropathy called? How does it present?
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Henoch Schenlein Purpura
Systemic vasculitis in children: RPGN Purpuric skin rash Colitis Arthritis |
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What do you see on IfA microscopy in people with IgA nephropathy?
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You see IgA!
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If someone is asian and is presenting with ESRD< what is the most common cause?
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IgA nephropathy
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What is the treatment for IgA nephropathy?
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Supportive --> we can't do anything.
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What is the treatment for ANCA positive small vessel vasculitides?
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IMMUNOSUPPRESSION!
This is very, very successful! |
